Search Results - "Trunet, P"

Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate by Dombernowsky, P, Smith, I, Falkson, G, Leonard, R, Panasci, L, Bellmunt, J, Bezwoda, W, Gardin, G, Gudgeon, A, Morgan, M, Fornasiero, A, Hoffmann, W, Michel, J, Hatschek, T, Tjabbes, T, Chaudri, H A, Hornberger, U, Trunet, P F

“…To compare two doses of letrozole and megestrol acetate (MA) as second-line therapy in postmenopausal women with advanced breast cancer previously treated with…”
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In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer by DOWSETT, M, JONES, A, JOHNSTON, S. R. D, JACOBS, S, TRUNET, P, SMITH, I. E

“…Thirteen postmenopausal women with advanced breast cancer were enrolled in an open randomized Phase I trial of a new p.o. active aromatase inhibitor, CGS 20267…”
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Letrozole, a new oral non-steroidal aromastase inhibitor in treating postmenopausal patients with advanced breast cancer. A pilot study by Bisagni, G., Cocconi, G., Scaglione, F., Fraschini, F., Pfister, Ch, Trunet, P. F.

“…Purpose To evaluate the endocrine effects as well as the pharmacokinetic parameters, efficacy and safety of letrozole, a new fourth-generation non-steroidal…”
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Letrozole (CGS 20267). A phase I study of a new potent oral aromatase inhibitor of breast cancer by Lipton, A, Demers, L M, Harvey, H A, Kambic, K B, Grossberg, H, Brady, C, Adlercruetz, H, Trunet, P F, Santen, R J

“…Letrozole (CGS 20267), a triazole derivative, is a new, once-daily, oral nonsteroidal inhibitor of aromatase activity. In this Phase I trial, 23 heavily…”
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Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in postmenopausal patients with advanced breast cancer by IVESON, T. J, SMITH, I. E, SMITHERS, D. A, TRUNET, P. F, DOWSETT, M

“…A phase I study was performed of CGS 20267, an oral nonsteroidal, highly potent, and selective aromatase inhibitor, in 21 postmenopausal patients with advanced…”
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Letrozole: updated duration of response by Chaudri, H A, Trunet, P F

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Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women by Iveson, T J, Smith, I E, Ahern, J, Smithers, D A, Trunet, P F, Dowsett, M

“…We have performed a phase I study of the effect of a single dose of CGS 20267, an oral nonsteroidal aromatase inhibitor, in 12 healthy volunteer postmenopausal…”
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Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects by Trunet, P F, Mueller, P, Bhatnagar, A S, Dickes, I, Monnet, G, White, G

“…The aim of this open, dose-finding study was to evaluate the effects of single dose CGS 20 267, a new oral nonsteroidal aromatase inhibitor, on the inhibition…”
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Therapeutic effects of the aromatase inhibitor fadrozole hydrochloride in advanced breast cancer by BONNEFOI, H. R, SMITH, I. E, DOWSETT, M, TRUNET, P. F, HOUSTON, S. J, DA LUZ, R. J, RUBENS, R. D, COOMBES, R. C, POWLES, T. J

“…The endocrine and therapeutic effects of the aromatase inhibitor fadrozole hydrochloride have been assessed in 80 post-menopausal patients with recurrent…”
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The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects by Trunet, P F, Mueller, P, Girard, F, Aupetit, B, Bhatnagar, A S, Zognbi, F, Ezzet, F, Menard, J

“…The aim of this double blind placebo-controlled cross-over study was to evaluate the effects of fadrozole, a new oral nonsteroidal aromatase inhibitor, on…”
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Letrozole: which dose to be used? by Buzdar, A U, Chaudri, H A, Trunet, P F

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Endocrine changes with the aromatase inhibitor fadrozole hydrochloride in breast cancer by Dowsett, M, Smithers, D, Moore, J, Trunet, P F, Coombes, R C, Powles, T J, Rubens, R, Smith, I E

“…Fadrozole hydrochloride is a potent aromatase inhibitor with proven clinical effectiveness. However, its optimal dose and its effects on serum aldosterone…”
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Inhibition of estrogen biosynthesis and its consequences on gonadotrophin secretion in the male by Bhatnagar, A S, Müller, P, Schenkel, L, Trunet, P F, Beh, I, Schieweck, K

“…Of the gonadal steroids in the male, testosterone is the most important regulator of gonadotrophin secretion. However, whether testosterone affects…”
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Clinical use of aromatase inhibitors in the treatment of advanced breast cancer by Trunet, Patrick F., Vreeland, Franzanne, Royce, Catherine, Chaudri, Hilary A., Cooper, Judy, Bhatnagar, Ajay S.

“…The aim of endocrine therapy is to reduce the estrogenic stimulus for tumour growth. After failure of tamoxifen — the standard “first-line” hormonotherapy for…”
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CENTRAL BLOOD PRESSURE AND AUGMENTATION INDEX DECREASE ARE DEPENDENT ON AORTIC PULSE WAVE VELOCITY IMPROVEMENT: THE EXPLOR STUDY: PP.10.406 by Boutouyrie, P, Achouba, A, Trunet, P, Ong, Kt, Laurent, S

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Effect of omalizumab in health care workers with occupational latex allergy by Leynadier, Francisque, Doudou, Ouafia, Gaouar, Hafida, Gros, Vincent Le, Bourdeix, Isabelle, Guyomarch-Cocco, Laurence, Trunet, Patrick

“…Omalizumab, a recombinant and humanized mAb, has been shown to be clinically efficacious in the treatment of patients with allergic asthma2 and rhinitis.3 On…”
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Influence of age, previous health status, and severity of acute illness on outcome from intensive care by Le Gall, J R, Brun-Buisson, C, Trunet, P, Latournerie, J, Chantereau, S, Rapin, M

“…Age, previous health status (HS), and severity of acute illness were assessed prospectively on 228 unselected patients admitted over 1 yr to the…”
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Pirprofen-induced fulminant hepatitis by Danan, G, Trunet, P, Bernuau, J, Degott, C, Babany, G, Pessayre, D, Rueff, B, Benhamou, J P

“…We report the cases of 2 female patients aged 69 and 61 yr, suffering from fulminant hepatitis induced by pirprofen, a new nonsteroidal antiinflammatory drug…”
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The role of iatrogenic disease in admissions to intensive care by Trunet, P, Le Gall, J R, Lhoste, F, Regnier, B, Saillard, Y, Carlet, J, Rapin, M

“…We prospectively studied all patients admitted to a multidisciplinary intensive care unit to determine how many of their diseases were iatrogenic and, of…”
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Influence of caloric intake on the respiratory mode during mandatory minute volume ventilation by Laaban, J P, Lemaire, F, Baron, J F, Trunet, P, Harf, A, Bonnet, J L, Teisseire, B

“…Mandatory minute volume ventilation has been proposed as a method for weaning patients from ventilators. The purpose of this study was to delineate the…”
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