Search Results - "Trune, Dennis"

Vascular Pathophysiology in Hearing Disorders by Trune, Dennis R, Nguyen-Huynh, Anh

“…The inner ear vasculature is responsible for maintenance of the blood-labyrinth barrier, transport of systemic hormones for ion homeostasis, and supplying…”
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Corticosteroid Therapy for Hearing and Balance Disorders by Trune, Dennis R., Canlon, Barbara

“…This review addresses the current status of steroid therapies for hearing and vestibular disorders and how certain misconceptions may be undermining the…”
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Otitis media impacts hundreds of mouse middle and inner ear genes by MacArthur, Carol J, Hausman, Fran, Kempton, J Beth, Choi, Dongseok, Trune, Dennis R

“…Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene…”
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Ion homeostasis in the ear: mechanisms, maladies, and management by Trune, Dennis R

“…To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore…”
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Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier by Zhang, Wenjing, Dai, Min, Fridberger, Anders, Hassan, Ahmed, DeGagne, Jacqueline, Neng, Lingling, Zhang, Fei, He, Wenxuan, Ren, Tianying, Trune, Dennis, Auer, Manfred, Shi, Xiaorui

“…The microenvironment of the cochlea is maintained by the barrier between the systemic circulation and the fluids inside the stria vascularis. However, the…”
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Intratympanic Steroid Treatments May Improve Hearing via Ion Homeostasis Alterations and Not Immune Suppression by MacArthur, Carol, Hausman, Fran, Kempton, Beth, Trune, Dennis R

“…HYPOTHESISThe inner ear (IE) endothelium is capable of responding to therapeutic steroids by altering the local expression of cytokine and ion homeostasis…”
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Correlative mRNA and protein expression of middle and inner ear inflammatory cytokines during mouse acute otitis media by Trune, Dennis R., Kempton, Beth, Hausman, Frances A., Larrain, Barbara E., MacArthur, Carol J.

“…Although the inner ear has long been reported to be susceptible to middle ear disease, little is known of the inflammatory mechanisms that might cause…”
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Intratympanically Delivered Steroids Impact Thousands More Inner Ear Genes Than Systemic Delivery by Trune, Dennis R., Shives, Katherine D., Hausman, Fran, Kempton, J. Beth, MacArthur, Carol J., Choi, Dongseok

“…Objectives: Glucocorticoids are given for sensorineural hearing loss, but little is known of their molecular impact on the inner ear. Furthermore, in spite of…”
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In silico Single-Cell Analysis of Steroid-Responsive Gene Targets in the Mammalian Cochlea by Nelson, Lacey, Lovett, Braeden, Johns, J Dixon, Gu, Shoujun, Choi, Dongseok, Trune, Dennis, Hoa, Michael

“…Treatment of many types of hearing instability in humans, including sudden sensorineural hearing loss, Meniere's disease, and autoimmune inner ear disease,…”
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Control of middle ear inflammatory and ion homeostasis genes by transtympanic glucocorticoid and mineralocorticoid treatments by Lighthall, Jessyka G, Kempton, J Beth, Hausman, Frances, MacArthur, Carol J, Trune, Dennis R

“…Transtympanic steroid treatment will induce changes in ion homeostasis and inflammatory gene expression to decrease middle ear inflammation due to bacterial…”
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Mouse middle ear ion homeostasis channels and intercellular junctions by Morris, Lisa M, DeGagne, Jacqueline M, Kempton, J Beth, Hausman, Frances, Trune, Dennis R

“…The middle ear contains homeostatic mechanisms that control the movement of ions and fluids similar to those present in the inner ear, and are altered during…”
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Differential expression of innate immunity genes in chronic rhinosinusitis by Detwiller, Kara Y, Smith, Timothy L, Alt, Jeremiah A, Trune, Dennis R, Mace, Jess C, Sautter, Nathan B

“…Prior research has identified several components of the innate immune system that may play a significant role in chronic rhinosinusitis (CRS), but the role of…”
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Altered expression of middle and inner ear cytokines in mouse otitis media by MacArthur, Carol J., Pillers, De-Ann M., Pang, Jiaqing, Kempton, J. Beth, Trune, Dennis R.

“…Objectives/Hypothesis: The inner ear is at risk for sensorineural hearing loss in both acute and chronic otitis media (OM), but the mechanisms underlying…”
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Effect of Systemic Lipopolysaccharide-Induced Inflammation on Cytokine Levels in the Murine Cochlea: A Pilot Study by Quintanilla-Dieck, Lourdes, Larrain, Barbara, Trune, Dennis, Steyger, Peter S.

“…The objective was to detect changes in cytokine expression within cochleae in a murine model of systemic inflammation, with or without aminoglycoside exposure…”
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Tissue remodeling gene expression in a murine model of chronic rhinosinusitis by Sautter, Nathan B., Delaney, Katherine L., Hausman, Frances A., Trune, Dennis R.

“…Objective/Hypothesis: The matrix metalloproteinase (MMP), fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) families regulate tissue…”
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Low dose combination steroids control autoimmune mouse hearing loss by Trune, Dennis R, Kempton, J. Beth

“…Abstract The severe side effects of glucocorticoids prevent long term management of hearing loss. Alternative steroid treatments that minimize or eliminate…”
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Correction: Mouse Middle Ear Ion Homeostasis Channels and Intercellular Junctions by Morris, Lisa M., DeGagne, Jacqueline M., Kempton, J. Beth, Hausman, Frances, Trune, Dennis R.

“…The version of Figure 1 that exists in the article is incorrect. The correct version can be found here: thumbnail Download: * PPT PowerPoint slide * PNG larger…”
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Inner ear tissue remodeling and ion homeostasis gene alteration in murine chronic otitis media by MacArthur, Carol J, Hausman, Fran, Kempton, J Beth, Sautter, Nathan, Trune, Dennis R

“…Studies were designed to ascertain the impact of chronic middle ear infection on the numerous ion and water channels, transporters, and tissue remodeling genes…”
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Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear by Trune, Dennis R., Kempton, J. Beth, Gross, Neil D.

“…The standard treatment for many hearing disorders is glucocorticoid therapy, although the cochlear mechanisms involved in steroid-responsive hearing loss are…”
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The Cochlear Pericytes by Shi, Xiaorui, Han, Weijiu, Yamamoto, Hiroshi, Tang, Wenxue, Lin, Xi, Xiu, Ruijuan, Trune, Dennis R., Nuttall, Alfred L.

“…Objectives: Cochlear pericytes are not well characterized. The aim of this study was to further advance the characterization of cochlear pericyte location and…”
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