Bioperformance Studies of Biphasic Calcium Phosphate Scaffolds Extracted from Fish Bones Impregnated with Free Curcumin and Complexed with β-Cyclodextrin in Bone Regeneration

Bioperformance Studies of Biphasic Calcium Phosphate Scaffolds Extracted from Fish Bones Impregnated with Free Curcumin and Complexed with β-Cyclodextrin in Bone Regeneration

Fish bones are a natural calcium phosphate (CaP) sources used in biomaterials production for bone regeneration. CaP scaffolds can be enriched with other substances with biological activity to improve bone repair. This study aimed to evaluate the physicochemical properties and bone regeneration poten...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Vol. 12; no. 3; p. 383
Main Authors: Truite, Cecilia V R, Noronha, Jessica N G, Prado, Gabriela C, Santos, Leonardo N, Palácios, Raquel S, do Nascimento, Adriane, Volnistem, Eduardo A, da Silva Crozatti, Thamara T, Francisco, Carolina P, Sato, Francielle, Weinand, Wilson R, Hernandes, Luzmarina, Matioli, Graciette
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 28-02-2022
MDPI
Subjects:
Animals
Apatite
beta-Cyclodextrins - pharmacology
Biological activity
biomaterials
Biomedical materials
biphasic calcium phosphate
Bone biomaterials
Bone growth
Bone healing
Bone Regeneration
Bones
Calcium phosphates
Calvaria
Curcumin
Curcumin - pharmacology
Fish
Fourier transforms
Growth factors
Hydroxyapatites
materials engineering
Morphology
Osteogenesis
Particle size
Physicochemical properties
Porosity
Powder metallurgy
Rats
Regeneration
Tilapia
Tissue engineering
Tissue Scaffolds - chemistry
β-Cyclodextrin
United Kingdom > UK
Japan
Germany
bone regeneration
biomaterials
materials engineering
biphasic calcium phosphate
β-cyclodextrin
curcumin
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Summary:Fish bones are a natural calcium phosphate (CaP) sources used in biomaterials production for bone regeneration. CaP scaffolds can be enriched with other substances with biological activity to improve bone repair. This study aimed to evaluate the physicochemical properties and bone regeneration potential of biphasic calcium phosphate (BCP) scaffolds impregnated with free curcumin (BCP-CL) or complexed with β-cyclodextrin (BCP-CD) compared to BCP scaffolds. Rietveld's refinement showed that BCP is composed of 57.2% of HAp and 42.8% of β-TCP and the molar ratio of Ca/P corresponds to 1.59. The scaffolds presented porosity (macro and microporosity) of 57.21%. Apatite formation occurred on the BCP, BCP-CL, and BCP-CD surface, in vitro, in SBF. Micro-Raman technique showed a reduction in the dissolution rate of β-TCP in the curcumin-impregnated scaffolds over time, and in vivo studies on critical-size defects, in rat calvaria, had no additional regenerative effect of BCP-CL and BCP-CD scaffolds, compared to BCP scaffolds. Despite this, the study showed that curcumin impregnation in BCP scaffolds prolongs the release of the β-TCP phase, the BCP- phase with the higher osteoinductive potential, representing an advantage in tissue engineering.
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ISSN:2218-273X
2218-273X
DOI:10.3390/biom12030383