Search Results - "Truex, Nicholas"

β‑Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides by Ruttenberg, Sarah M., Kreutzer, Adam G., Truex, Nicholas L., Nowick, James S.

“…Amyloid-β (Aβ) forms heterogeneous oligomers, which are implicated in the pathogenesis of Alzheimer’s disease (AD). Many Aβ oligomers consist of β-hairpin…”
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Assembly of Peptides Derived from β‑Sheet Regions of β‑Amyloid by Truex, Nicholas L, Wang, Yilin, Nowick, James S

“…In Alzheimer’s disease, aggregation of the β-amyloid peptide (Aβ) results in the formation of oligomers and fibrils that are associated with neurodegeneration…”
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Correction to “β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides” by Ruttenberg, Sarah M., Kreutzer, Adam G., Truex, Nicholas L., Nowick, James S.

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Coassembly of Peptides Derived from β‑Sheet Regions of β‑Amyloid by Truex, Nicholas L, Nowick, James S

“…In this paper, we investigate the coassembly of peptides derived from the central and C-terminal regions of the β-amyloid peptide (Aβ). In the preceding paper,…”
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Palladium-peptide oxidative addition complexes for bioconjugation by Rojas, Anthony J, Wolfe, Justin M, Dhanjee, Heemal H, Buslov, Ivan, Truex, Nicholas L, Liu, Richard Y, Massefski, Walter, Pentelute, Bradley L, Buchwald, Stephen L

“…The synthesis of palladium oxidative addition complexes derived from unprotected peptides is described. Incorporation of 4-halophenylalanine into a peptide…”
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Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins by Gazvoda, Martin, Dhanjee, Heemal H, Rodriguez, Jacob, Brown, Joseph S, Farquhar, Charlotte E, Truex, Nicholas L, Loas, Andrei, Buchwald, Stephen L, Pentelute, Bradley L

“…Carboranes represent a class of compounds with increasing therapeutic potential. However, few general approaches to readily embed carboranes into small…”
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A Tetramer Derived from Islet Amyloid Polypeptide by Wang, Yilin, Kreutzer, Adam G, Truex, Nicholas L, Nowick, James S

“…Aggregation of the islet amyloid polypeptide (IAPP) to form fibrils and oligomers is important in the progression of type 2 diabetes. This article describes…”
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Anthrax Protective Antigen Retargeted with Single‐Chain Variable Fragments Delivers Enzymes to Pancreatic Cancer Cells by Loftis, Alexander R., Santos, Michael S., Truex, Nicholas L., Biancucci, Marco, Satchell, Karla J. F., Pentelute, Bradley L.

“…The nontoxic, anthrax protective antigen/lethal factor N‐terminal domain (PA/LFN) complex is an effective platform for translocating proteins into the cytosol…”
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Transmembrane Proteins: Amyloids Hidden in Plain Sight? by Truex, Nicholas L, Nowick, James S

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Effects of N‑Terminal Residues on the Assembly of Constrained β‑Hairpin Peptides Derived from Aβ by Samdin, Tuan D, Wierzbicki, Michał, Kreutzer, Adam G, Howitz, William J, Valenzuela, Mike, Smith, Alberto, Sahrai, Victoria, Truex, Nicholas L, Klun, Matthew, Nowick, James S

“…This paper describes the synthesis, solution-phase biophysical studies, and X-ray crystallographic structures of hexamers formed by macrocyclic β-hairpin…”
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Correction to “Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins” by Gazvoda, Martin, Dhanjee, Heemal H., Rodriguez, Jacob, Brown, Joseph S., Farquhar, Charlotte E., Truex, Nicholas L., Loas, Andrei, Buchwald, Stephen L., Pentelute, Bradley L.

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Effects of charge and hydrophobicity on the oligomerization of peptides derived from IAPP by Wang, Yilin, Truex, Nicholas L., Vo, Ngoc D.P., Nowick, James S.

“…[Display omitted] Changes in pH resulting in modifications of charge can dramatically alter the folding and interaction of proteins. This article probes the…”
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Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy by Truex, Nicholas L., Holden, Rebecca L., Wang, Bin-You, Chen, Pu-Guang, Hanna, Stephanie, Hu, Zhuting, Shetty, Keerthi, Olive, Oriol, Neuberg, Donna, Hacohen, Nir, Keskin, Derin B., Ott, Patrick A., Wu, Catherine J., Pentelute, Bradley L.

“…High-throughput genome sequencing and computation have enabled rapid identification of targets for personalized medicine, including cancer vaccines. Synthetic…”
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A novel, safe, fast and efficient treatment for Her2‐positive and negative bladder cancer utilizing an EGF‐anthrax toxin chimera by Jack, Sherwin, Madhivanan, Kayalvizhi, Ramadesikan, Swetha, Subramanian, Sneha, Edwards, Daniel F., Elzey, Bennett D., Dhawan, Deepika, McCluskey, Andrew, Kischuk, Erin M., Loftis, Alexander R., Truex, Nicholas, Santos, Michael, Lu, Mike, Rabideau, Amy, Pentelute, Bradley, Collier, John, Kaimakliotis, Hristos, Koch, Michael, Ratliff, Timothy L., Knapp, Deborah W., Aguilar, Ruben C.

“…Bladder cancer is the sixth most common cancer in the United States, and it exhibits an alarming 70% recurrence rate. Thus, the development of more efficient…”
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Square channels formed by a peptide derived from transthyretin by Yoo, Stan, Kreutzer, Adam G, Truex, Nicholas L, Nowick, James S

“…High-resolution structures of peptide supramolecular assemblies are key to understanding amyloid diseases and designing peptide-based materials. This paper…”
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Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids by Lu, Zeyu, Paolella, Brenton R, Truex, Nicholas L, Loftis, Alexander R, Liao, Xiaoli, Rabideau, Amy E, Brown, Meredith S, Busanovich, John, Beroukhim, Rameen, Pentelute, Bradley L

“…Antisense oligonucleotide therapies are important cancer treatments, which can suppress genes in cancer cells that are critical for cell survival. has recently…”
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Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons by Truex, Nicholas L., Mohapatra, Somesh, Melo, Mariane, Rodriguez, Jacob, Li, Na, Abraham, Wuhbet, Sementa, Deborah, Touti, Faycal, Keskin, Derin B., Wu, Catherine J., Irvine, Darrell J., Gómez-Bombarelli, Rafael, Pentelute, Bradley L.

“…Antigen processing is critical for therapeutic vaccines to generate epitopes for priming cytotoxic T cell responses against cancer and pathogens, but…”
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Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells by Truex, Nicholas L., Rondon, Aurélie, Rössler, Simon L., Hanna, Cameron C., Cho, Yehlin, Wang, Bin-You, Backlund, Coralie M., Lutz, Emi A., Irvine, Darrell J., Pentelute, Bradley L.

“…Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of therapeutics that promote immunity against cancer and pathogenic…”
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IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells by Lu, Zeyu, Truex, Nicholas L, Melo, Mariane B, Cheng, Yiran, Li, Na, Irvine, Darrell J, Pentelute, Bradley L

“…Therapeutic immunotoxins composed of antibodies and bacterial toxins provide potent activity against malignant cells, but joining them with a defined covalent…”
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Pd-catalyzed cross-coupling reactions exhibiting catalyst turnover numbers (TONs) exceeding one million by Xu, Shiqing, Truex, Nicholas L., Mohan, Swathi, Negishi, Ei-ichi

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