Search Results - "Trueblood, Esther"

Expression of Trop2 Cell Surface Glycoprotein in Normal and Tumor Tissues: Potential Implications as a Cancer Therapeutic Target by Stepan, Lara P., Trueblood, Esther S., Hale, Kari, Babcook, John, Borges, Luis, Sutherland, Claire L.

“…Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of adenocarcinomas with minimal expression in normal tissues. Recent…”
Get full text

IL-1RL2 and its ligands contribute to the cytokine network in psoriasis by Blumberg, Hal, Dinh, Huyen, Dean, Jr, Charles, Trueblood, Esther S, Bailey, Keith, Shows, Donna, Bhagavathula, Narasimharao, Aslam, Muhammad Nadeem, Varani, James, Towne, Jennifer E, Sims, John E

“…Psoriasis is a common immune-mediated disease in European populations; it is characterized by inflammation and altered epidermal differentiation leading to…”
Get full text

Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation by Blumberg, Hal, Dinh, Huyen, Trueblood, Esther S, Pretorius, James, Kugler, David, Weng, Ning, Kanaly, Suzanne T, Towne, Jennifer E, Willis, Cynthia R, Kuechle, Melanie K, Sims, John E, Peschon, Jacques J

“…The interleukin (IL)-1 family members IL-1alpha, -1beta, and -18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of…”
Get full text

AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma by Hamblett, Kevin J, Kozlosky, Carl J, Siu, Sophia, Chang, Wesley S, Liu, Hua, Foltz, Ian N, Trueblood, Esther S, Meininger, David, Arora, Taruna, Twomey, Brian, Vonderfecht, Steven L, Chen, Qing, Hill, John S, Fanslow, William C

“…Epidermal growth factor receptor variant III (EGFRvIII) is a cancer-specific deletion mutant observed in approximately 25% to 50% of glioblastoma multiforme…”
Get full text

Brentuximab Vedotin-Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity by Heiser, Ryan A, Cao, Anthony T, Zeng, Weiping, Ulrich, Michelle, Younan, Patrick, Anderson, Martha E, Trueblood, Esther S, Jonas, Mechthild, Thurman, Robert, Law, Che-Leung, Gardai, Shyra J

“…Brentuximab vedotin, a CD30-directed antibody-drug conjugate (ADC), is approved for clinical use in multiple CD30-expressing lymphomas. The cytotoxic payload…”
Get more information

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways by Miner, Kent, Labitzke, Katja, Liu, Benxian, Wang, Paul, Henckels, Kathryn, Gaida, Kevin, Elliott, Robin, Chen, Jian Jeffrey, Liu, Longbin, Leith, Anh, Trueblood, Esther, Hensley, Kelly, Xia, Xing-Zhong, Homann, Oliver, Bennett, Brian, Fiorino, Mike, Whoriskey, John, Yu, Gang, Escobar, Sabine, Wong, Min, Born, Teresa L, Budelsky, Alison, Comeau, Mike, Smith, Dirk, Phillips, Jonathan, Johnston, James A, McGivern, Joseph G, Weikl, Kerstin, Powers, David, Kunzelmann, Karl, Mohn, Deanna, Hochheimer, Andreas, Sullivan, John K

“…There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent…”
Get full text

Development of Novel Antibody-Camptothecin Conjugates by Lyski, Ryan D, Bou, Lauren B, Lau, Uland Y, Meyer, David W, Cochran, Julia H, Okeley, Nicole M, Emmerton, Kim K, Zapata, Francisco, Simmons, Jessica K, Trueblood, Esther S, Ortiz, David J, Zaval, Margo C, Snead, Katie M, Jin, Steven, Farr, Lauren M, Ryan, Maureen C, Senter, Peter D, Jeffrey, Scott C

“…We have developed a highly active and well-tolerated camptothecin (CPT) drug-linker designed for antibody-mediated drug delivery in which the lead molecule…”
Get full text

Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis by Mozaffarian, Afsaneh, Brewer, Avery W, Trueblood, Esther S, Luzina, Irina G, Todd, Nevins W, Atamas, Sergei P, Arnett, Heather A

“…Oncostatin M (OSM), an IL-6 family cytokine, has been implicated in a number of biological processes including the induction of inflammation and the modulation…”
Get full text

SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models by Gray, Elizabeth, Ulrich, Michelle, Epp, Angela, Younan, Patrick, Sahetya, Disha, Hensley, Kelly, Allred, Sean, Huang, Li-Ya, Hahn, Julie, Gahnberg, Kristen, Treuting, Piper M, Trueblood, Esther S, Gosink, John J, Thurman, Robert, Wo, Serena, Spahr, Kellie, Haass, Evgenia Jane, Snead, Katie, Miller, Dannah, Padilla, Mary, Smith, Alyson J, Frantz, Chris, Schrum, Jason P, Nazarenko, Natalya, Gardai, Shyra J

“…BackgroundSGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the…”
Get full text

Mo2012 Augmentation of Colonic Inflammation by TL1A is Most Severe in the Presence of a Genetic Susceptibility and Bacterial Trigger by Maxwell, Joe, Brown, William, Gaida, Kevin, Lee, Fran, Trueblood, Esther S, Hsu, Hailing

Get full text

854 SGN-B7H4V, a novel, investigational vedotin antibody-drug conjugate directed to the T cell checkpoint ligand B7-H4, shows promising activity in preclinical models by Gray, Elizabeth, Epp, Angela, Ulrich, Michelle, Sahetya, Disha, Hensley, Kelly, Hahn, Julie, Allred, Sean, Haass, Jane, Snead, Katie, Lucas, Sasha, Gosink, John, Boyce, Rogely, Trueblood, Esther, Treuting, Piper, Frantz, Chris, Smith, Alyson, Schrum, Jason, Nazarenko, Natalya, Gardai, Shyra

“…BackgroundSGN-B7H4V is a novel, investigational vedotin antibody drug conjugate (ADC) directed to B7-H4, a member of the B7 family of immune checkpoint…”
Get full text

617 Tisotumab vedotin shows immunomodulatory activity through induction of immunogenic cell death by Gray, Elizabeth, Hensley, Kelly, Allred, Sean, Trueblood, Esther, Gosink, John, Thurman, Robert, Smith, Kaleb, Jacquemont, Celine, Bieda, Mark, Gow, Jason, Harris, Jeffrey, Brady, Lauren, Soumaoro, Ibrahima, Jain, Shweta, Nicacio, Leonardo, Gardai, Shyra

“…BackgroundTisotumab vedotin (TV) is an investigational antibody-drug conjugate composed of a tissue factor (TF)-directed human monoclonal antibody covalently…”
Get full text

Antagonists of CD117 (cKit) signaling inhibit mast cell accumulation in healing skin wounds by Zoog, Stephen J, Itano, Andrea, Trueblood, Esther, Pacheco, Efrain, Zhou, Lei, Zhang, Xuxia, Ferbas, John, Ng, Gordon Y, Juan, Gloria

“…Mast cells (MCs) have important functional roles in leukocyte recruitment, pain, and wound healing, and increased tissue resident MC function has been…”
Get full text

Automated Enumeration of Skin Mast Cells by Laser Scanning Cytometry by Trueblood, Esther, Director of Pathology, Amgen, Inc./Pathology, Seattle, WA, Z., Stephen, Scientist, Amgen, Inc./Clinical Immunology, Thousand Oaks, CA, Ita, Andrea, Senior Scientist, Amgen, Inc./Inflammation, Thousand Oaks, CA, Ferbas, John, Director Medical Sciences, Amgen, Inc./Clinical Immunology, Thousand Oaks, CA, Chung, James, Medical Sciences Director, Amgen, Inc./Early development, Thousand Oaks, CA, Ng, Gordon, Scientific Director, Amgen, Inc./Inflammation, Thousand Oaks, CA, Juan, Gloria, Senior Scientist, Amgen, Inc./Clinical Immunology, Thousand Oaks, CA

Get full text

Abstract 2906: SGN-B6A: A new MMAE ADC targeting integrin beta-6 in multiple carcinoma indications by Lyon, Robert P., Schmitt, Michael W., Jonas, Mechthild, Franz, Christopher E., Trueblood, Esther S., Yumul, Roma, Westendorf, Lori, Ryan, Maureen C.

“…Abstract The integrins are a large family of cell surface receptors with diverse roles in cellular adhesion, motility, and cytokinesis. Functional integrins…”
Get full text

Abstract 2688: SGN-CD228A: A novel humanized anti-CD228 antibody-drug conjugate for the treatment of solid tumors by Sandall, Sharsti L., Mason, Marsha, Olson, Devra, Mazahreh, Rebecca, Pires, Tom, Sahetya, Disha, Westendorf, Lori, Leiske, Chris, Schimpf, Brian, Nguyen, Liem, Katepalli, Madhu, Trueblood, Esther, Hale, Christopher, Nesterova, Albina, Wall, Jason, Lewis, Timothy S.

“…Abstract Melanotransferrin (CD228/MFI2/MELTF) is a cell-surfaced glycosylphosphatidylinoitol (GPI)-anchored glycoprotein that belongs to the transferrin family…”
Get full text

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat by Fielden, Mark R., Werner, Jonathan, Jamison, Jeff A., Coppi, Aldo, Hickman, Dean, Dunn, Robert T., Trueblood, Esther, Zhou, Lei, Afshari, Cynthia A., Lightfoot-Dunn, Ruth

“…β-Secretase 1 (BACE1) represents an attractive target for the treatment of Alzheimer’s disease. In the course of development of a novel small molecule BACE1…”
Get full text

Abstract 1766: SGN-ALPV a novel, investigational vedotin ADC demonstrates highly effective targeting of oncofetal phosphatases ALPP and ALPPL2 in preclinical models by Anderson, Sarah, Hansen, Nanna, Lawrence, Robert, Chande, Aroon T., Ortiz, David, Carosino, Christopher, Trueblood, Esther, Stevens, Nicole, Klussman, Kerry, Epp, Angela, Arthur, Bill, Gardai, Shyra, Rincon, Hector

“…Abstract Antibody-drug conjugates (ADC) leverage the specificity of antibodies to direct the delivery of potent cytotoxic agents to cancer cells. To fully…”
Get full text

Abstract 1140: Enfortumab vedotin, a Nectin-4 directed ADC, demonstrates compelling tolerability and anti-tumor activity with intravesical instillation in preclinical models of non-muscle invasive bladder cancer by Carosino, Christopher, Olson, Devra, Snead, Katie, Lee, Anthony, Farr, Lauren, Garg, Amit, O'Day, Christine, Trueblood, Esther, Wright, Jennifer, Bieda, Mark, Caldwell, Charles, Hensley, Kelly, Allred, Sean, Liu, Bernard, Shimazaki, Masashi, Sandall, Sharsti

“…Abstract Enfortumab vedotin (EV) is a monomethyl auristatin E (MMAE) containing antibody-drug conjugate directed to Nectin-4, which is highly expressed in…”
Get full text

253 : IL-36 induces inflammation and collagen deposition in the lung by Sun, Yu, Mozaffarian, Afsaneh, Arnett, Heather A., Dinh, Huyen, Trueblood, Esther S., Towne, Jennifer E.

“…IL-36α, IL-36β and IL-36g are members of the IL-1 family of cytokines which bind to the IL-36R leading to recruitment of the IL-1 receptor accessory protein…”
Get full text