Search Results - "Trubetskoy, V. S."

Vascular permeability in a human tumour xenograft: molecular charge dependence by DELLIAN, M, YUAN, F, TRUBETSKOY, V. S, TORCHILIN, V. P, JAIN, R. K

“…Molecular charge is one of the main determinants of transvascular transport. There are, however, no data available on the effect of molecular charge on…”
Get full text

Recharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene delivery by TRUBETSKOY, V. S, WONG, S. C, SUBBOTIN, V, BUDKER, V. G, LOOMIS, A, HAGSTROM, J. E, WOLFF, J. A

“…The intravenous delivery of plasmid DNA complexed with either cationic lipids (CL) or polyethyleneimine (PEI) enables high levels of foreign gene expression in…”
Get full text

Layer-by-layer deposition of oppositely charged polyelectrolytes on the surface of condensed DNA particles by Trubetskoy, Vladimir S., Loomis, Aaron, Hagstrom, James E., Budker, Vladimir G., Wolff, Jon A.

“…DNA can be condensed with an excess of polycations in aqueous solutions forming stable particles of submicron size with positive surface charge. This charge…”
Get full text

Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties by Trubetskoy, Vladimir S., Cannillo, John A., Milshtein, Alexander, Wolf, Gerald L., Torchilin, Vladimir P.

“…Surface modification of liposomes containing Gd-diethylenetriaminepentaacetyl-phosphatidylethanolamine (Gd-DTPA-PE) as an amphiphilic paramagnetic label…”
Get full text

New synthetic amphiphilic polymers for steric protection of liposomes in vivo by Torchilin, V P, Trubetskoy, V S, Whiteman, K R, Caliceti, P, Ferruti, P, Veronese, F M

“…Carboxy group-terminated synthetic polymers--branched poly(ethylene glycol), poly(acryloylmorpholine), and poly(vinylpyrrolidone)--were made amphiphilic by…”
Get more information

Block-copolymer of Polyethylene Glycol and Polylysine as a Carrier of Organic Iodine: Design of Long-circulating Particulate Contrast Medium for X-ray Computed Tomography by Trubetskoy, Vladimir S., Gazelle, G. Scott, Wolf, Gerald L., Torchilin, Vladimir P.

“…Abstract In order to obtain small, polymer-stabilized particulate carriers for organic iodine to serve as a contrast agent for X-ray computed tomography (CT)…”
Get full text

Use of N-terminal modified poly(L-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells by Trubetskoy, Vladimir S, Torchilin, Vladimir P, Kennel, Stephen J, Huang, Leaf

“…A DNA targeted delivery and expression system has been designed based on an N-terminal modified poly(L-lysine) (NPLL)-antibody conjugate, which readily forms a…”
Get full text

Massage-induced release of subcutaneously injected liposome-encapsulated drugs to the blood by Trubetskoy, Vladimir S, Whiteman, Kathleen R, Torchilin, Vladimir P, Wolf, Gerald L

“…Liposome-based, externally regulated drug delivery system is described in which liposome-encapsulated bioactive molecules can be delivered into the blood in…”
Get full text

Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly(L-lysine)-antibody conjugate in mouse lung endothelial cells by Trubetskoy, V S, Torchilin, V P, Kennel, S, Huang, L

“…A new and improved system for targeted gene delivery and expression is described. Transfection efficiency of N-terminal modified poly(L-lysine) (NPLL)…”
Get more information

Stable polymeric micelles: lymphangiographic contrast media for gamma scintigraphy and magnetic resonance imaging by Trubetskoy, V S, Frank-Kamenetsky, M D, Whiteman, K R, Wolf, G L, Torchilin, V P

“…Amphiphilic biocompatible polyoxyethylene (PEO)-based polymers form particles (micelles) that are 10-50 nm in diameter. In the current research, we…”
Get more information

Toxicity and immunogenicity of Neisseria meningitidis lipopolysaccharide incorporated into liposomes by PETROV, A. B, SEMENOV, B. F, DMITRIEV, B. A, VARTANYAN, Y. P, ZAKIROV, M. M, TORCHILIN, V. P, TRUBETSKOY, V. S, KOSHKINA, N. V, L'VOV, V. L, VERNER, I. K, LOPYREV, I. V

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Disulfide Cross-Linked Fab-Aggregates: Preparation and Biodistribution by Dalkaraa, S., Petrov, A., Trubetskoy, V. S., Khaw, B. A., Torchilin, V. P.

“…Abstract The high-molecular-weight soluble aggregates of Fab fragments of murine antibodies against cardiac myosin were prepared as a potential…”
Get full text

High throughput screening assay for UDP-glucuronosyltransferase 1A1 glucuronidation profiling by Trubetskoy, O V, Finel, M, Kurkela, M, Fitzgerald, M, Peters, N R, Hoffman, F M, Trubetskoy, V S

“…Development of high throughput screening (HTS) assays for evaluation of a compound's toxicity and potential for drug-drug interactions is a critical step…”
Get more information

Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity by Torchilin, V P, Omelyanenko, V G, Papisov, M I, Bogdanov, Jr, A A, Trubetskoy, V S, Herron, J N, Gentry, C A

“…The hypothetical model is built explaining the molecular mechanism of protective action of poly(ethylene glycol) on liposomes in vivo. The protective layer of…”
Get more information

Chemically optimized antimyosin Fab conjugates with chelating polymers: Importance of the nature of the protein-polymer single site covalent bond for biodistribution and infarction localization by Trubetskoy, Vladimir S, Narula, Jagat, Khaw, Ban An, Torchilin, Vladimir P

“…Murine antimyosin Fab fragment was conjugated with 111In-labeled N-terminal-modified DTPA-polylysine using three bifunctional reagents: N-hydroxysuccinimide…”
Get full text

Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo by Torchilin, V P, Shtilman, M I, Trubetskoy, V S, Whiteman, K, Milstein, A M

“…Newly synthesized amphiphilic polyacrylamide and poly(vinyl pyrrolidone), single terminus-modified with long-chain fatty acyl groups, are able to incorporate…”
Get more information

Caged DNA Does Not Aggregate in High Ionic Strength Solutions by Trubetskoy, Vladimir S, Loomis, Aaron, Slattum, Paul M, Hagstrom, James E, Budker, Vladimir G, Wolff, Jon A

“…The assembly of DNA into compact particles that do not aggregate in physiologic salt solution occurs naturally in chromatin and viral particles but has been…”
Get full text

FITC-labeled lipopolysaccharide: use as a probe for liposomal membrane incorporation studies by Trubetskoy, V.S., Koshkina, N.V., Omel'yanenko, V.G., L'vov, V.L., Dmitriev, B.A., Petrov, A.B., Torchilin, V.P.

“…FITC-labeled LPS from Neisseria meningitidis can be used as a probe to follow the process of LPS incorporation into liposomal membrane and to study its…”
Get full text

Self-assembly of DNA—polymer complexes using template polymerization by Trubetskoy, Vladimir S., Hanson, Lisa J., Slattum, Paul M., Hagstrom, James E., Budker, Vladimir G., Wolff, Jon A.

“…The self-assembly of supramolecular complexes of nucleic acids and polymers is of relevance to several biological processes including viral and chromatin…”
Get full text

Monoclonal antibody to human endothelial cell surface internalization and liposome delivery in cell culture by Trubetskaya, O.V., Trubetskoy, V.S., Domogatsky, S.P., Rudin, A.V., Popov, N.V., Danilov, S.M., Nikolayeva, M.N., Klibanov, A.L., Torchilin, V.P.

“…A monoclonal antibody (mAb), E25, is described that binds to the surface of cultured human endothelial cells. Upon binding E25 is rapidly internalized and…”
Get full text