Search Results - "Trube, G"

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro by Fischer, G, Mutel, V, Trube, G, Malherbe, P, Kew, J N, Mohacsi, E, Heitz, M P, Kemp, J A

“…The interaction of Ro 25-6981 with N-methyl-D-aspartate (NMDA) receptors was characterized by a variety of different tests in vitro. Ro 25-6981 inhibited…”
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P.1.g.041 RG1662, a new negative allosteric modulator of the gamma-aminobutyric acid Aα5 receptor subtype, does not show convulsions at relevant doses by Wandel, C, Thomas, A, Hernandez, M.C, Ballard-Yardy, T, Knoflach, F, Trube, G, Rothfuss, A, Husar, E, Lennon-Chrimes, S, Bentley, D, d'Ardhuy, X. Liogier, Squassante, L, Noeldeke, J, Khwaja, O

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A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries by Roche, Olivier, Trube, Gerhard, Zuegge, Jochen, Pflimlin, Pascal, Alanine, Alexander, Schneider, Gisbert

“…A computer‐based method has been developed for prediction of the hERG (human ether‐à‐go‐go related gene) K+‐channel affinity of low molecular weight compounds…”
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A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones by Kew, J N, Trube, G, Kemp, J A

“…1. Ifenprodil is a selective, atypical non-competitive antagonist of NMDA receptors that contain the NR2B subunit with an undefined mechanism of action…”
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Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition by Dorn, Arnulf, Hermann, Francis, Ebneth, Andreas, Bothmann, Hendrick, Trube, Gerhard, Christensen, Klaus, Apfel, Christian

“…The number of projects in drug development that fail in late phases because of cardiac side effects such as QT prolongation can impede drug discovery and…”
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Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions by Rorsman, P, Trube, G

“…Pancreatic islets of NMRI mice were dissociated into single cells which were kept in tissue culture for 1-3 days. The whole-cell configuration of the…”
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P.l.c.038 Modulation of dopaminergic activity in the mesolimbic system by trace amine-associated receptor 1 (TAAR1) modification by Revel, E.G, Bradaia, A, Trube, G, Stalder, H, Ozmen, L, Wettstein, J.G, Bettler, B, Hoener, M.C

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Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart by Sakmann, B, Trube, G

“…Single ventricular cells were enzymatically isolated from adult guinea-pig hearts (Isenberg & Klöckner, 1982). The patch-clamp technique (Hamill, Marty,…”
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Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells by TRUBE, G, RORSMAN, P, OHNO-SHOSAKU, T

“…The influence of the antidiabetic sulphonylurea tolbutamide on K+ channels of mouse pancreatic beta-cells was investigated using different configurations of…”
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Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist by Gill, R, Alanine, A, Bourson, A, Buttelmann, B, Fischer, G, Heitz, M-P, Kew, J N C, Levet-Trafit, B, Lorez, H-P, Malherbe, P, Miss, M-T, Mutel, V, Pinard, E, Roever, S, Schmitt, M, Trube, G, Wybrecht, R, Wyler, R, Kemp, J A

“…Ro 63-1908, 1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol, is a novel subtype-selective N-methyl-D-aspartate (NMDA) antagonist that has…”
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Glucose dependent K+-channels in pancreatic β-cells are regulated by intracellular ATP by RORSMAN, P, TRUBE, G

“…The resting conductance of cultured beta-cells from murine pancreases was investigated using the whole-cell, cell-attached and isolated patch modes of the…”
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Voltage-dependent inactivation of inward-rectifying single-channel currents in the guinea-pig heart cell membrane by Sakmann, B, Trube, G

“…Inward currents through single K+ channels in isolated ventricular heart cells of the guinea-pig were recorded using the patch-clamp technique (Hamill, Marty,…”
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Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches by Trube, G, Hescheler, J

“…Inward rectifying potassium single-channel currents were studied in the membrane of guinea pig cardiac myocytes. In isolated inside-out patches two different…”
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Dextromethorphan: cellular effects reducing neuronal hyperactivity by Trube, G, Netzer, R

“…Dextromethorphan is a dextrorotary morphinan without affinity for opioid receptors, commonly used as an antitussive medication. During the past 5 years,…”
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Changes of membrane currents in cardiac cells induced by long whole-cell recordings and tolbutamide by BELLES, B, HESCHELER, J, TRUBE, G

“…Single isolated myocytes were obtained from the ventricles of adult guinea pig hearts. The whole-cell recording configuration of the patch-clamp technique was…”
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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity by Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Bradaia, Amyaouch, Sotnikova, Tatyana D, Mory, Roland, Durkin, Sean, Zbinden, Katrin Groebke, Norcross, Roger, Meyer, Claas A, Metzler, Veit, Chaboz, Sylvie, Ozmen, Laurence, Trube, Gerhard, Pouzet, Bruno, Bettler, Bernhard, Caron, Marc G, Wettstein, Joseph G, Hoener, Marius C

“…The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has…”
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Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells by ZÜNKLER, B. J, LENZEN, S, MÄNNER, K, PANTEN, U, TRUBE, G

“…The influence of the hypoglycemic drugs tolbutamide, meglitinide, glipizide and glibenclamide on ATP-dependent K+ currents of mouse pancreatic B-cells was…”
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Dual effects of ATP on K+ currents of mouse pancreatic β-cells by OHNO-SHOSAKU, T, ZÜNKLER, B. J, TRUBE, G

“…K+ currents through ATP-dependent channels were recorded from inside-out patches of beta-cell membrane as previously described (Rorsman and Trube 1985)…”
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Single Ca channel currents in mouse pancreatic B-cells by Rorsman, P, Ashcroft, F M, Trube, G

“…Barium currents flowing through single Ca2+ channels were recorded from outside-out patches isolated from mouse pancreatic B-cells. Only one type of Ca2+…”
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Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane? by Hescheler, J, Pelzer, D, Trube, G, Trautwein, W

“…The effects of extra- and intracellularly applied D600 (methoxyverapamil) and D890 (a quarternary derivative) on the action potentials of isolated guinea pig…”
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