Search Results - "Troyanovsky, Sergey M"

Binding to F-actin guides cadherin cluster assembly, stability, and movement by Hong, Soonjin, Troyanovsky, Regina B, Troyanovsky, Sergey M

“…The cadherin extracellular region produces intercellular adhesion clusters through trans- and cis-intercadherin bonds, and the intracellular region connects…”
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Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex by Choi, Jongho, Troyanovsky, Regina B, Indra, Indrajyoti, Mitchell, Brian J, Troyanovsky, Sergey M

“…The basolateral protein Scribble (Scrib), a member of the LAP protein family, is essential for epithelial apicobasal polarity (ABP) in However, a conserved…”
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MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins by Seo, Tadahiko, Lowery, Anthony M, Xu, Haifang, Giang, William, Troyanovsky, Sergey M, Vincent, Peter A, Kowalczyk, Andrew P

“…Cadherin family proteins play a central role in epithelial and endothelial cell-cell adhesion. The dynamic regulation of cell adhesion is achieved in part…”
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The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins by Harrison, Oliver J., Jin, Xiangshu, Hong, Soonjin, Bahna, Fabiana, Ahlsen, Goran, Brasch, Julia, Wu, Yinghao, Vendome, Jeremie, Felsovalyi, Klara, Hampton, Cheri M., Troyanovsky, Regina B., Ben-Shaul, Avinoam, Frank, Joachim, Troyanovsky, Sergey M., Shapiro, Lawrence, Honig, Barry

“…Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains…”
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Spatial and temporal organization of cadherin in punctate adherens junctions by Indra, Indrajyoti, Choi, Jongho, Chen, Chi-Shuo, Troyanovsky, Regina B., Shapiro, Lawrence, Honig, Barry, Troyanovsky, Sergey M.

“…Adherens junctions (AJs) play a fundamental role in tissue integrity; however, the organization and dynamics of the key AJ transmembrane protein, E-cadherin,…”
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Spontaneous Assembly and Active Disassembly Balance Adherens Junction Homeostasis by Hong, Soonjin, Troyanovsky, Regina B., Troyanovsky, Sergey M., Honig, Barry H.

“…The homeostasis of adherens junctions was studied using E-cadherin and its two mutants tagged by the photoconvertible protein Dendra2 in epithelial A-431 cells…”
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Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin by Gupta, Jyoti, Rangarajan, Erumbi S, Troyanovsky, Regina B, Indra, Indrajyoti, Troyanovsky, Sergey M, Izard, Tina

“…Plakophilin-3 is a ubiquitously expressed protein found widely in epithelial cells and is a critical component of desmosomes. The plakophilin-3…”
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Sensing Actin Dynamics through Adherens Junctions by Indra, Indrajyoti, Troyanovsky, Regina B., Shapiro, Lawrence, Honig, Barry, Troyanovsky, Sergey M.

“…We study punctate adherens junctions (pAJs) to determine how short-lived cadherin clusters and relatively stable actin bundles interact despite differences in…”
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Cadherin exits the junction by switching its adhesive bond by Hong, Soonjin, Troyanovsky, Regina B, Troyanovsky, Sergey M

“…The plasticity of cell-cell adhesive structures is crucial to all normal and pathological morphogenetic processes. The molecular principles of this plasticity…”
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Nectin ectodomain structures reveal a canonical adhesive interface by Harrison, Oliver J, Vendome, Jeremie, Brasch, Julia, Jin, Xiangshu, Hong, Soonjin, Katsamba, Phinikoula S, Ahlsen, Goran, Troyanovsky, Regina B, Troyanovsky, Sergey M, Honig, Barry, Shapiro, Lawrence

“…Nectins and nectin-like proteins promote intercellular adhesion and tissue patterning in vertebrates through homophilic or heterophilic interactions. Now the…”
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E-cadherin junction formation involves an active kinetic nucleation process by Biswas, Kabir H., Hartman, Kevin L., Yu, Cheng-han, Harrison, Oliver J., Song, Hang, Smith, Adam W., Huang, William Y. C., Lin, Wan-Chen, Guo, Zhenhuan, Padmanabhan, Anup, Troyanovsky, Sergey M., Dustin, Michael L., Shapiro, Lawrence, Honig, Barry, Zaidel-Bar, Ronen, Groves, Jay T.

“…Epithelial (E)-cadherin-mediated cell−cell junctions play important roles in the development and maintenance of tissue structure in multicellular organisms…”
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Trans -endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells by Generous, Alex R, Harrison, Oliver J, Troyanovsky, Regina B, Mateo, Mathieu, Navaratnarajah, Chanakha K, Donohue, Ryan C, Pfaller, Christian K, Alekhina, Olga, Sergeeva, Alina P, Indra, Indrajyoti, Thornburg, Theresa, Kochetkova, Irina, Billadeau, Daniel D, Taylor, Matthew P, Troyanovsky, Sergey M, Honig, Barry, Shapiro, Lawrence, Cattaneo, Roberto

“…Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a…”
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Adherens junction: the ensemble of specialized cadherin clusters by Troyanovsky, Sergey M.

“…The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane receptors, type I cadherins (referred to here as cadherins). These…”
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Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly by Troyanovsky, Regina B, Sokolov, Eugene P, Troyanovsky, Sergey M

“…The adhesion receptor E-cadherin maintains cell-cell junctions by continuously forming short-lived adhesive dimers. Here mixed culture cross-linking and…”
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Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion by Troyanovsky, Regina B, Laur, Oscar, Troyanovsky, Sergey M

“…Numerous attempts to elucidate the strength of cadherin dimerization that mediates intercellular adhesion have produced controversial and inconclusive results…”
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Adhesive and Lateral E-Cadherin Dimers Are Mediated by the Same Interface by Troyanovsky, Regina B., Sokolov, Eugene, Troyanovsky, Sergey M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex by Indra, Indrajyoti, Troyanovsky, Regina B, Green, Kathleen J, Troyanovsky, Sergey M

“…Desmosomes (DSMs), together with adherens junctions (AJs) and tight junctions (TJs), constitute the apical cell junctional complex (AJC). While the importance…”
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Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity by Troyanovsky, Regina B., Indra, Indrajyoti, Kato, Rei, Mitchell, Brian J., Troyanovsky, Sergey M.

“…Scribble, a member of the LAP protein family, contributes to the apicobasal polarity (ABP) of epithelial cells. The LAP-unique region of these proteins, which…”
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Sorting of cadherin–catenin-associated proteins into individual clusters by Troyanovsky, Regina B., Sergeeva, Alina P., Indra, Indrajyoti, Chen, Chi-Shuo, Kato, Rei, Shapiro, Lawrence, Honig, Barry, Troyanovsky, Sergey M.

“…The cytoplasmic tails of classical cadherins form a multiprotein cadherin–catenin complex (CCC) that constitutes the major structural unit of adherens…”
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α-Catenin-mediated cadherin clustering couples cadherin and actin dynamics by Chen, Chi-Shuo, Hong, Soonjin, Indra, Indrajyoti, Sergeeva, Alina P, Troyanovsky, Regina B, Shapiro, Lawrence, Honig, Barry, Troyanovsky, Sergey M

“…The function of the actin-binding domain of α-catenin, αABD, including its possible role in the direct anchorage of the cadherin-catenin complex to the actin…”
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