Search Results - "Troy, Carol M."

Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease by Avrutsky, Maria I., Troy, Carol M.

“…Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue…”
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Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions by Baleriola, Jimena, Walker, Chandler A., Jean, Ying Y., Crary, John F., Troy, Carol M., Nagy, Peter L., Hengst, Ulrich

“…In Alzheimer’s disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire…”
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Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion by Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.

“…Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of…”
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Mechanisms of neuronal death in disease: defining the models and the players by Ribe, Elena M, Serrano-Saiz, Esther, Akpan, Nsikan, Troy, Carol M

“…Dysregulation of life and death at the cellular level leads to a variety of diseases. In the nervous system, aberrant neuronal death is an outstanding feature…”
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Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline by Colón Ortiz, Crystal, Neal, Albertine M., Avrutsky, Maria I., Choi, Monica, Smart, Jade, Lawson, Jacqueline, Troy, Carol M.

“…Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic…”
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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion by Avrutsky, Maria I, Chen, Claire W, Lawson, Jacqueline M, Snipas, Scott J, Salvesen, Guy S, Troy, Carol M

“…Retinal vein occlusion (RVO) is a sight-threatening condition typically treated with intravitreal injection of vascular endothelial growth factor (VEGF)…”
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Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline by Colón Ortiz, Crystal, Neal, Albertine M., Avrutsky, Maria I., Choi, Monica, Smart, Jade, Lawson, Jacqueline, Troy, Carol M.

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Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant by Di Donato, Nataliya, Jean, Ying Y., Maga, A. Murat, Krewson, Briana D., Shupp, Alison B., Avrutsky, Maria I., Roy, Achira, Collins, Sarah, Olds, Carissa, Willert, Rebecca A., Czaja, Agnieszka M., Johnson, Rachel, Stover, Jessi A., Gottlieb, Steven, Bartholdi, Deborah, Rauch, Anita, Goldstein, Amy, Boyd-Kyle, Victoria, Aldinger, Kimberly A., Mirzaa, Ghayda M., Nissen, Anke, Brigatti, Karlla W., Puffenberger, Erik G., Millen, Kathleen J., Strauss, Kevin A., Dobyns, William B., Troy, Carol M., Jinks, Robert N.

“…Lissencephaly is a malformation of cortical development typically caused by deficient neuronal migration resulting in cortical thickening and reduced gyration…”
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Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics by Bosc, Elodie, Anastasie, Julie, Soualmia, Feryel, Coric, Pascale, Kim, Ju Youn, Wang, Lily Q., Lacin, Gullen, Zhao, Kaitao, Patel, Ronak, Duplus, Eric, Tixador, Philippe, Sproul, Andrew A., Brugg, Bernard, Reboud-Ravaux, Michelle, Troy, Carol M., Shelanski, Michael L., Bouaziz, Serge, Karin, Michael, El Amri, Chahrazade, Jacotot, Etienne D.

“…Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease (AD)…”
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Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion by Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures by Al-Dalahmah, Osama, Sosunov, Alexander A, Sun, Yu, Liu, Yang, Madden, Nacoya, Connolly, E Sander, Troy, Carol M, McKhann, 2nd, Guy M, Goldman, James E

“…In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter…”
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Neuronal caspase 2 activity and function requires RAIDD, but not PIDD by Ribe, Elena M, Jean, Ying Y, Goldstein, Rebecca L, Manzl, Claudia, Stefanis, Leonidas, Villunger, Andreas, Troy, Carol M

“…Caspase 2 was initially identified as a neuronally expressed developmentally down-regulated gene (HUGO gene nomenclature CASP2) and has been shown to be…”
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Highly Efficient Small Interfering RNA Delivery to Primary Mammalian Neurons Induces MicroRNA-Like Effects before mRNA Degradation by Davidson, Thomas J, Harel, Sivan, Arboleda, Valerie A, Prunell, Giselle F, Shelanski, Michael L, Greene, Lloyd A, Troy, Carol M

“…The study of protein function in neurons has been hindered by the lack of highly efficient, nontoxic methods of inducing RNA interference in such cells. Here…”
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Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death by Jean, Ying Y, Ribe, Elena M, Pero, Maria Elena, Moskalenko, Marina, Iqbal, Zarah, Marks, Lianna J, Greene, Lloyd A, Troy, Carol M

“…Neuronal apoptotic death generally requires de novo transcription, and activation of the transcription factor c-Jun has been shown to be necessary in multiple…”
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Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice by Montroull, Laura E., Rothbard, Deborah E., Kanal, Hur D., D’Mello, Veera, Dodson, Vincent, Troy, Carol M., Zanin, Juan P., Levison, Steven W., Friedman, Wilma J.

“…The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is…”
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Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection by Tamayev, Robert, Akpan, Nsikan, Arancio, Ottavio, Troy, Carol M, D'Adamio, Luciano

“…Mutations in either Aβ Precursor protein (APP) or genes that regulate APP processing, such as BRI2/ITM2B and PSEN1/PSEN2, cause familial dementias. Although…”
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Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling by VIGNESWARA, Vasanthy, AKPAN, Nsikan, BERRY, Martin, LOGAN, Ann, TROY, Carol M, AHMED, Zubair

“…We have previously shown that crushing the optic nerve induces death of retinal ganglion cells by apoptosis, but suppression of CASP2, which is predominantly…”
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Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory by Puzzo, Daniela, Privitera, Lucia, Fa', Mauro, Staniszewski, Agnieszka, Hashimoto, Gakuji, Aziz, Fahad, Sakurai, Mikako, Ribe, Elena M., Troy, Carol M., Mercken, Marc, Jung, Sonia S., Palmeri, Agostino, Arancio, Ottavio

“…Objective: The goal of this study was to investigate the role of endogenous amyloid‐β peptide (Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a…”
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Death in the Balance: Alternative Participation of the Caspase-2 and -9 Pathways in Neuronal Death Induced by Nerve Growth Factor Deprivation by Troy, Carol M, Rabacchi, Sylvia A, Hohl, Justin B, Angelastro, James M, Greene, Lloyd A, Shelanski, Michael L

“…The data presented here demonstrate that sympathetic neurons have the potential to activate two alternative caspase-dependent pathways either of which is…”
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Caspase Inhibitors: Prospective Therapies for Stroke by Akpan, Nsikan, Troy, Carol M.

“…In ischemic stroke, apoptosis persists for days to weeks after the onset of an ischemic event. Cysteine-ASPartic proteASEs (caspases) are key mediators of…”
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