Search Results - "Trown, Patrick"

Improved pharmacokinetics and tumor localization of immunotoxins constructed with the Mr 30,000 form of ricin A chain by TROWN, P. W, REARDAN, D. T, CARROLL, S. F, STOUDEMIRE, J. B, KAWAHATA, R. T

“…The two naturally occurring forms of ricin A chain, Mr 33,000 and Mr 30,000 (RTA33 and RTA30) have been purified, and their chemical compositions, toxicities,…”
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Relationship between binding affinities to cellular retinoic acid-binding protein and in vivo and in vitro properties for 18 retinoids by Trown, P W, Palleroni, A V, Bohoslawec, O, Richelo, B N, Halpern, J M, Gizzi, N, Geiger, R, Lewinski, C, Machlin, L J, Jetten, A, Jetten, M E

“…A new rapid assay has been developed for measurement of the binding of [3H]retinoic acid to cellular retinoic acid-binding protein. The assay, which uses…”
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Fluorinated retinoic acids and their analogs. 1. Synthesis and biological activity of (4-methoxy-2,3,6-trimethylphenyl)nonatetraenoic acid analogs by Pawson, Beverly A, Chan, Ka-Kong, DeNoble, James, Han, Ru Jen L, Piermattie, Virginia, Specian, Anthony C, Srisethnil, Srisamorn, Trown, Patrick W, Bohoslawec, Oksana

“…(4-Methoyx-2,3,6-trimethylphenyl)nonatetraenoic acids, esters, and amides (analogues of retinoic acid) bearing a fluorine atom(s) or a trifluoromethyl group on…”
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Plasma and cerebrospinal fluid pharmacokinetics of recombinant interferon alpha A in monkeys: comparison of intravenous, intramuscular, and intraventricular delivery by Collins, J M, Riccardi, R, Trown, P, O'Neill, D, Poplack, D G

“…Interferons are currently undergoing clinical testing in patients with cancer and other diseases. A variety of routes of administration are being utilized, and…”
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Effect of aromatic retinoids on rat chondrosarcoma glycosaminoglycan biosynthesis by Shapiro, S S, Bishop, M, Poon, J P, Trown, P W

“…Synthetic aromatic analogs of retinoic acid were administered i.p. and p.o. to Fischer F344 rats bearing a transplantable chondrosarcoma. 35CO4 incorporation…”
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Dihydroretinoic acids and their derivatives. Synthesis and biological activity by Pawson, Beverly A, Cheung, H. C, Han, Ru-Jen L, Trown, Patrick W, Buck, Margaret, Hansen, Roseanne, Bollag, W, Ineichen, U, Pleil, H

“…The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids…”
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An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity by Theofan, G, Horwitz, AH, Williams, RE, Liu, PS, Chan, I, Birr, C, Carroll, SF, Meszaros, K, Parent, JB, Kasler, H

“…LPS-binding protein (LBP) mediates the pro-inflammatory effects of bacterial LPS by enhancing LPS-induced cytokine production by monocytic cells. LBP binds…”
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Use of an Anti-Pan T-Lymphocyte Ricin A Chain Immunotoxin in Steroid-Resistant Acute Graft-Versus-Host Disease by Byers, Vera S., Henslee, P.Jean, Kernan, Nancy A., Blazar, Bruce Ft, Gingrich, Roger, Phillips, Gordon L., LeMaistre, C.F., Gilliland, Gary, Antin, Joseph H., Martin, Paul, Tutscha, Peter J., Trown, Patrick, Ackerman, Samuel K., O'Reilly, Richard J., Scannon, Patrick J.

“…Acute steroid-resistant graft-versus-host disease (AGVHD) after allogeneic bone marrow transplantation is frequently fatal. A new treatment for this…”
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Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon alfa-2a by intramuscular injection by Itri, L M, Campion, M, Dennin, R A, Palleroni, A V, Gutterman, J U, Groopman, J E, Trown, P W

“…More than 1600 patients with neoplastic disorders have received recombinant human interferon alfa-2a (Roferon-A, Hoffmann-La Roche, Nutley, NJ) as part of…”
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Measurement of bactericidal/permeability-increasing protein in human body fluids by sandwich ELISA by White, M L, Ma, J K, Birr, C A, Trown, P W, Carroll, S F

“…A sensitive sandwich ELISA has been developed to measure levels of native bactericidal/permeability-increasing protein (BPI) as well as two recombinant forms…”
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The preclinical development of Roferon-A by Trown, P W, Wills, R J, Kamm, J J

“…Interferon alfa-2a (Roferon-A, Hoffmann-La Roche Inc., Nutley, NJ) is identical to one of approximately 15 subtypes of interferon alpha made by human…”
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INHIBITION OF CARBOXYDISMUTASE BY IODOACETAMIDE by RABIN, B R, TROWN, P W

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Inhibition of Carboxydismutase by Iodoacetamide by Rabin, Brian R., Trown, Patrick W.

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Pharmacokinetics and tissue distribution of recombinant human alpha A, D, A/D(Bgl), and I interferons and mouse alpha-interferon in mice by Bohoslawec, O, Trown, P W, Wills, R J

“…The pharmacokinetics and tissue distribution in mice of several recombinant human alpha-interferons [rHuIFN-alpha A, D, I, and A/D(Bgl)] as well as natural…”
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Synergistic interaction between interferon-alpha and acyclovir in the treatment of herpes simplex virus type 1 infection in mice by Cerruti, R L, Connell, E V, Trown, P W, Sim, I S

“…Hairless mice were infected intracutaneously with HSV-1 and treated with rHuIFN-alpha A/D, a recombinant DNA-derived hybrid human interferon-alpha that is…”
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A sensitive radioimmunoassay for detection of antibodies to recombinant human interferon-alpha A by Palleroni, A V, Trown, P W

“…A radioimmunoassay (RIA) for the detection of antibodies to recombinant human leukocyte interferon A (rHuIFN-alpha A) in human serum has been developed and…”
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The Mechanism of Action of Carboxydismutase by Trown, Patrick W., Rabin, Brian R.

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