Search Results - "Trowbridge, Ian S"

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development by Trowbridge, Ian S, Thomas, Matthew L

“…CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms…”
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Structural Requirements for Basolateral Sorting of the Human Transferrin Receptor in the Biosynthetic and Endocytic Pathways of Madin-Darby Canine Kidney Cells by Odorizzi, Greg, Trowbridge, Ian S.

“…In polarized Madin-Darby canine kidney (MDCK) cells, the transferrin receptor (TR) is selectively delivered to the basolateral surface, where it internalizes…”
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Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate by JONES, Dylan T, TROWBRIDGE, Ian S, HARRIS, Adrian L

“…Cellular iron is needed for cell survival and hydroxylation of hypoxia-inducible factor-1alpha (HIF-alpha) by prolyl hydroxylases (PHD). One mechanism of iron…”
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Endocytosis and signals for internalization by Trowbridge, I S

“…The most important recent advance in the field of endocytosis has been the identification of the internalization signals of several constitutively recycling…”
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In Migrating Fibroblasts, Recycling Receptors Are Concentrated in Narrow Tubules in the Pericentriolar Area, and Then Routed to the Plasma Membrane of the Leading Lamella by Hopkins, Colin R., Gibson, Adèle, Shipman, Mark, Strickland, Dudley K., Trowbridge, Ian S.

“…By following the intracellular processing of recycling transferrin receptors and the selective sorting of a-2 macroglobulin in chick embryo fibroblasts, we…”
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Apical and Basolateral Endosomes of MDCK Cells Are Interconnected and Contain a Polarized Sorting Mechanism by Odorizzi, Greg, Pearse, Adele, Domingo, Derrick, Trowbridge, Ian S., Hopkins, Colin R.

“…We have evaluated transcytotic routes in MDCK cells for their ability to generate a polarized surface distribution of trafficking proteins by following the…”
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Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis by Collawn, J F, Stangel, M, Kuhn, L A, Esekogwu, V, Jing, S Q, Trowbridge, I S, Tainer, J A

“…Using detailed functional studies on 24 human transferrin receptor mutants, we identified YXRF as the internalization sequence. Provided that at least 7…”
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Sorting Signals in the MHC Class II Invariant Chain Cytoplasmic Tail and Transmembrane Region Determine Trafficking to an Endocytic Processing Compartment by Odorizzi, C. Greg, Trowbridge, Ian S., Xue, Luzheng, Hopkins, Colin R., Davis, Cynthia D., Collawn, James F.

“…Targeting of MHC class II molecules to the endocytic compartment where they encounter processed antigen is determined by the invariant chain (Ii). By analysis…”
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Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts by Perschl, A, Lesley, J, English, N, Hyman, R, Trowbridge, I S

“…The hyaluronan receptor CD44 is an abundant glycoprotein expressed on a variety of different cell types. In fibroblasts a significant portion of receptor…”
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Structural Requirements for Major Histocompatibility Complex Class II Invariant Chain Trafficking in Polarized Madin-Darby Canine Kidney Cells by Odorizzi, G, Trowbridge, I S

“…The invariant chain (Ii) targets major histocompatibility complex class II molecules to an endocytic processing compartment where they encounter antigenic…”
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Negative Regulation of CD45 Protein Tyrosine Phosphatase Activity by Ionomycin in T Cells by Ostergaard, Hanne L., Trowbridge, Ian S.

“…CD45 is a leukocyte-specific, transmembrane protein tyrosine phosphatase (PTPase) required for T cell responsiveness. How the activity of PTPases is regulated…”
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Combinations of anti-transferrin receptor monoclonal antibodies inhibit human tumor cell growth in vitro and in vivo: evidence for synergistic antiproliferative effects by White, S, Taetle, R, Seligman, P A, Rutherford, M, Trowbridge, I S

“…Thirty-two murine monoclonal antibodies (MAbs) against the external domain of the human transferrin (Tf) receptor have been obtained using human Tf receptor…”
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Detection of a novel human class II HLA antigen by Watson, Andrew J, DeMars, Robert, Trowbridge, Ian S, Bach, Fritz H

“…Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatability complex (MHC) in man have led to the definition of three different…”
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Analysis of the Structural Requirements for Lysosomal Membrane Targeting Using Transferrin Receptor Chimeras by White, Suhaila, Hatton, Sean R., Siddiqui, Masood A., Parker, Cynthia D., Trowbridge, Ian S., Collawn, James F.

“…The sorting of membrane proteins to the lysosome requires tyrosine- or dileucine-based targeting signals. Recycling receptors have similar signals, yet these…”
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Anti-transferrin receptor monoclonal antibody and toxin-antibody conjugates affect growth of human tumour cells by Trowbridge, Ian S, Domingo, Derrick L

“…The development of the monoclonal antibody technique has led to renewed interest in whether the growth of tumour cells may be specifically inhibited by…”
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The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid by Sefton, B M, Trowbridge, I S, Cooper, J A, Scolnick, E M

“…We have found that the transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus all contain tightly bound lipid. This modification…”
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Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues by Trowbridge, I S, Lesley, J, Schulte, R, Hyman, R, Trotter, J

“…A murine leukocyte surface glycoprotein (Mr = 95 000) has been defined by means of xenogeneic monoclonal antibodies. In normal hematopoietic tissues, the…”
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Human cell-surface glycoprotein with unusual properties by Omary, M. Bishr, Trowbridge, Ian S, Minowada, Jun

“…We report here the identification of human cell-surface glycoprotein with unusual and interesting properties. We initially detected this glycoprotein on the…”
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Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor β -chain gene by Trowbridge, Ian S, Lesley, Jayne, Trotter, Joseph, Hyman, Robert

“…The development of T cells within the thymus is not well understood. It is known that thymocytes are derived from a progenitor cell in the bone marrow, the…”
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Isolation and Chemical Characterization of a Mitogenic Lectin from Pisum sativum by Trowbridge, Ian S.

“…A mitogenic lectin has been isolated from garden peas (Pisum sativum) by affinity chromatography on Sephadex. The lectin has a molecular weight of 49,000,…”
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