Search Results - "Trowbridge, I"

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development by Trowbridge, Ian S, Thomas, Matthew L

“…CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms…”
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In Polarized MDCK Cells Basolateral Vesicles Arise from Clathrin-γ-Adaptin-Coated Domains on Endosomal Tubules by Futter, C. E., Gibson, A., Allchin, E. H., Maxwell, S., Ruddock, L. J., Odorizzi, G., Domingo, D., Trowbridge, I. S., Hopkins, C. R.

“…Human transferrin receptors (TR) and receptors for polymeric immunoglobulins (pIgR) expressed in polarized MDCK cells maintain steady-state, asymmetric…”
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Expression of CD45 Alters Phosphorylation of the lck-Encoded Tyrosine Protein Kinase in Murine Lymphoma T-Cell Lines by Ostergaard, Hanne L., Shackelford, Deborah A., Hurley, Tamara R., Johnson, Pauline, Hyman, Robert, Sefton, Bartholomew M., Trowbridge, Ian S.

“…CD45 is a family of high molecular weight leukocyte cell surface glycoproteins. Recently, two related subregions of the cytoplasmic domain of CD45 have been…”
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In Migrating Fibroblasts, Recycling Receptors Are Concentrated in Narrow Tubules in the Pericentriolar Area, and Then Routed to the Plasma Membrane of the Leading Lamella by Hopkins, Colin R., Gibson, Adèle, Shipman, Mark, Strickland, Dudley K., Trowbridge, Ian S.

“…By following the intracellular processing of recycling transferrin receptors and the selective sorting of a-2 macroglobulin in chick embryo fibroblasts, we…”
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CD45 : a prototype for transmembrane protein tyrosine phosphatases by TROWBRIDGE, I. S

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Changes in CD45 Isoform Expression Accompany Antigen-Induced Murine T-Cell Activation by Birkeland, Marian L., Johnson, Pauline, Trowbridge, Ian S., Puré, Ellen

“…Leukocytes express a family of plasma membrane proteins called CD45 or the leukocyte common antigen. Isoforms of various molecular masses, 180-240 kDa, are…”
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Apical and Basolateral Endosomes of MDCK Cells Are Interconnected and Contain a Polarized Sorting Mechanism by Odorizzi, Greg, Pearse, Adele, Domingo, Derrick, Trowbridge, Ian S., Hopkins, Colin R.

“…We have evaluated transcytotic routes in MDCK cells for their ability to generate a polarized surface distribution of trafficking proteins by following the…”
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Sorting Mechanisms Regulating Membrane Protein Traffic in the Apical Transcytotic Pathway of Polarized MDCK Cells by Gibson, A., Futter, C. E., Maxwell, S., Allchin, E. H., Shipman, M., J.-P. Kraehenbuhl, Domingo, D., Odorizzi, G., Trowbridge, I. S., Hopkins, C. R.

“…The transcytotic pathway followed by the polymeric IgA receptor (pIgR) carrying its bound ligand (dIgA) from the basolateral to the apical surface of polarized…”
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Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis by Collawn, J F, Stangel, M, Kuhn, L A, Esekogwu, V, Jing, S Q, Trowbridge, I S, Tainer, J A

“…Using detailed functional studies on 24 human transferrin receptor mutants, we identified YXRF as the internalization sequence. Provided that at least 7…”
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Role of the Human Transferrin Receptor Cytoplasmic Domain in Endocytosis: Localization of a Specific Signal Sequence for Internalization by Jing, Shuqian, Spencer, Terry, Miller, Karen, Hopkins, Colin, Trowbridge, Ian S.

“…Wild-type and mutant human transferrin receptors have been expressed in chicken embryo fibroblasts using a helper-independent retroviral vector. The…”
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Sorting Signals in the MHC Class II Invariant Chain Cytoplasmic Tail and Transmembrane Region Determine Trafficking to an Endocytic Processing Compartment by Odorizzi, C. Greg, Trowbridge, Ian S., Xue, Luzheng, Hopkins, Colin R., Davis, Cynthia D., Collawn, James F.

“…Targeting of MHC class II molecules to the endocytic compartment where they encounter processed antigen is determined by the invariant chain (Ii). By analysis…”
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Internalization and Processing of Transferrin and the Transferrin Receptor in Human Carcinoma A431 Cells by Hopkins, Colin R., Trowbridge, Ian S.

“…The binding and subsequent intracellular processing of transferrin and transferrin receptors was studied in A431 cells using125I-transferrin and a monoclonal…”
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YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis by COLLAWN, J. F, LAI, A, DOMINGO, D, FITCH, M, HATTON, S, TROWBRIDGE, I. S

“…By functional analysis of mutant human transferrin receptors (TR) expressed in chicken embryo fibroblasts, we previously identified a tetrapeptide sequence,…”
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Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors by CHIA-PING CHANG, LAZAR, C. S, WILEY, H. S, GILL, G. N, WALSH, B. J, KOMURO, M, COLLAWN, J. F, KUHN, L. A, TAINER, J. A, TROWBRIDGE, I. S, FARQUHAR, M. G, ROSENFELD, M. G

“…Ligand-induced internalization of epidermal growth factor (EGF) receptors via a high affinity saturable pathway requires sequences located in the carboxyl…”
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Structural variants of human T200 glycoprotein (leukocyte‐common antigen) by Ralph, S. J., Thomas, M. L., Morton, C. C., Trowbridge, I. S.

“…Structural variation in the primary structure of human T200 glycoprotein has been detected. Three cDNA variants have been characterized each of which encode…”
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Transferrin receptors promote the formation of clathrin lattices by Miller, K, Shipman, M, Trowbridge, I S, Hopkins, C R

“…Gold conjugates have been used to quantitate human transferrin receptors (hTfnRs) on transfected chick embryo fibroblasts. No relationship could be found…”
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Structural Requirements for Basolateral Sorting of the Human Transferrin Receptor in the Biosynthetic and Endocytic Pathways of Madin-Darby Canine Kidney Cells by Odorizzi, Greg, Trowbridge, Ian S.

“…In polarized Madin-Darby canine kidney (MDCK) cells, the transferrin receptor (TR) is selectively delivered to the basolateral surface, where it internalizes…”
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Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain by Lai, A, Sisodia, S S, Trowbridge, I S

“…The beta-amyloid precursor protein (APP) is proteolytically processed to generate beta-amyloid protein, the principal protein component of neuropathological…”
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Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid‐attachment site by Jing, S.Q., Trowbridge, I.S.

“…Structural studies of the human transferrin receptor have shown that the molecule is a disulfide‐bonded dimer consisting of two identical subunits (Mr =…”
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Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit by Brenner, M B, Trowbridge, I S, Strominger, J L

“…Bifunctional cross-linking reagents DSP, DSS, and BSOCOES were used to cross-link 125I-surface-labeled viable T lymphocytes. The cross-linked cells were…”
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