Search Results - "Troutwine, Benjamin R"

The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine by Troutwine, Benjamin R., Gontarz, Paul, Konjikusic, Mia J., Minowa, Ryoko, Monstad-Rios, Adrian, Sepich, Diane S., Kwon, Ronald Y., Solnica-Krezel, Lilianna, Gray, Ryan S.

“…Cerebrospinal fluid (CSF) physiology is important for the development and homeostasis of the central nervous system, and its disruption has been linked to…”
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Apolipoprotein E and Alzheimer's disease by Troutwine, Benjamin R., Hamid, Laylan, Lysaker, Colton R., Strope, Taylor A., Wilkins, Heather M.

“…Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk. APOE ε4 alleles are the strongest genetic risk factor for late onset…”
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Mitochondrial function and Aβ in Alzheimer's disease postmortem brain by Troutwine, Benjamin R., Strope, Taylor A., Franczak, Edziu, Lysaker, Colton R., Hamid, Laylan, Mansel, Clayton, Stopperan, Julia A., Gouvion, Cynthia M., Haeri, Mohammad, Swerdlow, Russell H., Wilkins, Heather M.

“…Mitochondrial dysfunction is observed in Alzheimer's disease (AD). However, the relationship between functional mitochondrial deficits and AD pathologies is…”
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Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease by Flannagan, Kaitlin, Stopperan, Julia A., Hauger, Brittany M., Troutwine, Benjamin R., Lysaker, Colton R., Strope, Taylor A., Csikos Drummond, Vivien, Gilmore, Caleb A., Swerdlow, Natalie A., Draper, Julia M., Gouvion, Cynthia M., Vivian, Jay L., Haeri, Mohammad, Swerdlow, Russell H., Wilkins, Heather M.

“…Introduction: Mitochondrial dysfunction is observed in Alzheimer's disease (AD). Altered mitochondrial respiration, cytochrome oxidase (COX) Vmax, and…”
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Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10 , as Adolescent Idiopathic Scoliosis Candidate Genes by Wang, Yunjia, Liu, Zhenhao, Yang, Guanteng, Gao, Qile, Xiao, Lige, Li, Jiong, Guo, Chaofeng, Troutwine, Benjamin R, Gray, Ryan S, Xie, Lu, Zhang, Hongqi

“…Adolescent idiopathic scoliosis (AIS) is the most common pediatric spine disorder affecting ∼3% of children worldwide. Human genetic studies suggest a complex…”
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The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish by Wang, Yunjia, Troutwine, Benjamin R., Zhang, Hongqi, Gray, Ryan S.

“…Adolescent idiopathic scoliosis (AIS) is a common pediatric musculoskeletal disorder worldwide, characterized by atypical spine curvatures in otherwise healthy…”
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Mitochondrial Membrane Potential Influences Amyloid-β Protein Precursor Localization and Amyloid-β Secretion by Wilkins, Heather M, Troutwine, Benjamin R, Menta, Blaise W, Manley, Sharon J, Strope, Taylor A, Lysaker, Colton R, Swerdlow, Russell H

“…Amyloid-β (Aβ), which derives from the amyloid-β protein precursor (AβPP), forms plaques and serves as a fluid biomarker in Alzheimer's disease (AD). How Aβ…”
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Mitochondrial dysfunction in models of Progressive Supranuclear Palsy by Troutwine, Benjamin R, Lysaker, Colton R, Strope, Taylor A., Swerdlow, Russell H, Wilkins, Heather M

“…Background Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disease hallmarked by tau pathology in both neurons and astrocytes. Familial forms…”
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The Functional Role of Amyloid Precursor Protein at Mitochondria by Strope, Taylor A., Troutwine, Benjamin R, Lysaker, Colton R, Wilkins, Heather M

“…Background Aβ is generated from amyloid precursor protein (APP) via sequential proteolytic processing. While APP processing and its localization are well…”
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Mitochondrial Phenotypes in iPSC AD Models by Flannagan, Kaitlin, Stopperan, Julia A., Troutwine, Benjamin R, Lysaker, Colton R, Strope, Taylor A., Draper, Julia, Shaddy‐Gouvion, Cynthia, Vivian, Jay, Haeri, Mohammad, Wilkins, Heather M

“…Background Mitochondrial dysfunction is observed in Alzheimer’s disease (AD). Altered mitochondrial respiration, cytochrome oxidase (COX) Vmax, and mitophagy…”
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Mitochondrial DNA drives AD Phenotypes in Cell Models by Troutwine, Benjamin R, Weidling, Ian, John, Casey S., Green, Zachary D., Kueck, Paul J., Swerdlow, Russell H, Wilkins, Heather M, Morris, Jill K.

“…Background Mitochondrial DNA (mtDNA) inheritance influences Alzheimer’s Disease (AD) risk. Adult children of mother’s afflicted with AD show decreased…”
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Impacts of Aerobic Capacity, Liver Function, and Metabolism on Brain Health by Lysaker, Colton R, Troutwine, Benjamin R, Strope, Taylor A., Franczak, Edziu M, Allen, Julie A, Chauhan, Munish, Harris, Janna L, Thyfault, John P, Wilkins, Heather M

“…Background Aerobic capacity (VO2 max) strongly influences biological functions including both liver and brain function. Low aerobic capacity has far reaching…”
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Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway by Troutwine, B. R., Ghezzi, A., Pietrzykowski, A. Z., Atkinson, N. S.

“…Reduction in Toll pathway activity decreases ethanol resistance, while activation of the Toll pathway increases resistance. A growing body of evidence has…”
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