Search Results - "Troutman, Ty D."

Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease by Troutman, Ty D., Kofman, Eric, Glass, Christopher K.

“…The development and functional potential of metazoan cells is dependent on combinatorial roles of transcriptional enhancers and promoters. Macrophages provide…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Heterogeneity of HSCs in a Mouse Model of NASH by Rosenthal, Sara Brin, Liu, Xiao, Ganguly, Souradipta, Dhar, Debanjan, Pasillas, Martina P., Ricciardelli, Eugenia, Li, Rick Z., Troutman, Ty D., Kisseleva, Tatiana, Glass, Christopher K., Brenner, David A.

“…Background and Aims In clinical and experimental NASH, the origin of the scar‐forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to…”
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis by Sun, Xiaoli, Seidman, Jason S., Zhao, Peng, Troutman, Ty D., Spann, Nathanael J., Que, Xuchu, Zhou, Fangli, Liao, Zhongji, Pasillas, Martina, Yang, Xiaohong, Magida, Jason A., Kisseleva, Tatiana, Brenner, David A., Downes, Michael, Evans, Ronald M., Saltiel, Alan R., Tsimikas, Sotirios, Glass, Christopher K., Witztum, Joseph L.

“…Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis…”
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Epigenetic Regulation of Kupffer Cell Function in Health and Disease by Bennett, Hunter, Troutman, Ty D, Sakai, Mashito, Glass, Christopher K

“…Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue macrophages in the body. Within the liver sinusoids Kupffer cells…”
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Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis by Arimoto, Kei-ichiro, Miyauchi, Sayuri, Troutman, Ty D., Zhang, Yue, Liu, Mengdan, Stoner, Samuel A., Davis, Amanda G., Fan, Jun-Bao, Huang, Yi-Jou, Yan, Ming, Glass, Christopher K., Zhang, Dong-Er

“…While immunotherapy has emerged as a breakthrough cancer therapy, it is only effective in some patients, indicating the need of alternative therapeutic…”
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages by Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.

“…Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models…”
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Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation by Shao, Tzu-Yu, Jiang, Tony T., Stevens, Joseph, Russi, Abigail E., Troutman, Ty D., Bernieh, Anas, Pham, Giang, Erickson, John J., Eshleman, Emily M., Alenghat, Theresa, Jameson, Stephen C., Hogquist, Kristin A., Weaver, Casey T., Haslam, David B., Deshmukh, Hitesh, Way, Sing Sing

“…Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion…”
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Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice by Moore, Spencer M., Seidman, Jason S., Ellegood, Jacob, Gao, Richard, Savchenko, Alex, Troutman, Ty D., Abe, Yohei, Stender, Josh, Lee, Daehoon, Wang, Sicong, Voytek, Bradley, Lerch, Jason P., Suh, Hoonkyo, Glass, Christopher K, Muotri, Alysson R.

“…SETD5 , a gene linked to intellectual disability (ID) and autism spectrum disorder (ASD), is a member of the SET-domain family and encodes a putative histone…”
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Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches by Troutman, Ty D., Bennett, Hunter, Sakai, Mashito, Seidman, Jason S., Heinz, Sven, Glass, Christopher K.

“…Significant advancements in understanding disease mechanisms can occur through combined analysis of next-generation sequencing datasets generated using…”
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An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells by Texari, Lorane, Spann, Nathanael J., Troutman, Ty D., Sakai, Mashito, Seidman, Jason S., Heinz, Sven

“…Integrative analysis of next-generation sequencing data can help understand disease mechanisms. Specifically, ChIP-seq can illuminate where transcription…”
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Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis by Proper, Steven P, Dwyer, Alexander T, Appiagyei, Andrews, Felton, Jennifer M, Ben-Baruch Morgenstern, Netali, Marlman, Justin M, Kotliar, Michael, Barski, Artem, Troutman, Ty D, Rothenberg, Marc E, Mersha, Tesfaye B, Azouz, Nurit P

“…Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon…”
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Breaking down the complex pathophysiology of eosinophilic esophagitis by Underwood, Brynne, Troutman, Ty D., Schwartz, Justin T.

“…Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of the esophagus associated with antigen-driven type 2 inflammation and…”
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity by Sakai, Mashito, Troutman, Ty D., Seidman, Jason S., Ouyang, Zhengyu, Spann, Nathanael J., Abe, Yohei, Ego, Kaori M., Bruni, Cassi M., Deng, Zihou, Schlachetzki, Johannes C.M., Nott, Alexi, Bennett, Hunter, Chang, Jonathan, Vu, BaoChau T., Pasillas, Martina P., Link, Verena M., Texari, Lorane, Heinz, Sven, Thompson, Bonne M., McDonald, Jeffrey G., Geissmann, Frederic, Glass, Christopher K.

“…Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular…”
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An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S] by Allan, Christopher M., Heizer, Patrick J., Tu, Yiping, Sandoval, Norma P., Jung, Rachel S., Morales, Jazmin E., Sajti, Eniko, Troutman, Ty D., Saunders, Thomas L., Cusanovich, Darren A., Beigneux, Anne P., Romanoski, Casey E., Fong, Loren G., Young, Stephen G.

“…Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential…”
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Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function by Link, Verena M., Duttke, Sascha H., Chun, Hyun B., Holtman, Inge R., Westin, Emma, Hoeksema, Marten A., Abe, Yohei, Skola, Dylan, Romanoski, Casey E., Tao, Jenhan, Fonseca, Gregory J., Troutman, Ty D., Spann, Nathanael J., Strid, Tobias, Sakai, Mashito, Yu, Miao, Hu, Rong, Fang, Rongxin, Metzler, Dirk, Ren, Bing, Glass, Christopher K.

“…Non-coding genetic variation is a major driver of phenotypic diversity and allows the investigation of mechanisms that control gene expression. Here, we…”
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Eosinophil Specialization Is Regulated by Exposure to the Esophageal Epithelial Microenvironment by Dunn, Julia L M, Szep, Andrea, Gonzalez Galan, Emily, Zhang, Simin, Marlman, Justin, Caldwell, Julie, Troutman, Ty D, Rothenberg, Marc E

“…Distinct subsets of eosinophils are reported in inflammatory and healthy tissues, yet the functions of uniquely specialized eosinophils and the signals that…”
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes by Bennett, Hunter, Troutman, Ty D., Zhou, Enchen, Spann, Nathanael J., Link, Verena M., Seidman, Jason S., Nickl, Christian K., Abe, Yohei, Sakai, Mashito, Pasillas, Martina P., Marlman, Justin M., Guzman, Carlos, Hosseini, Mojgan, Schnabl, Bernd, Glass, Christopher K.

“…Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of…”
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A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation by Abe, Yohei, Kofman, Eric R, Ouyang, Zhengyu, Cruz-Becerra, Grisel, Spann, Nathanael J, Seidman, Jason S, Troutman, Ty D, Stender, Joshua D, Taylor, Havilah, Fan, Weiwei, Link, Verena M, Shen, Zeyang, Sakai, Juro, Downes, Michael, Evans, Ronald M, Kadonaga, James T, Rosenfeld, Michael G, Glass, Christopher K

“…The nuclear receptor corepressor (NCoR) forms a complex with histone deacetylase 3 (HDAC3) that mediates repressive functions of unliganded nuclear receptors…”
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Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes

“…Genetic and environmental diversity are major drivers of macrophage transcriptional responses, but the mechanisms that underlie the relative contributions of…”
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