Search Results - "Trout, Robert E Lee"

Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2 by Willette, Robert N, Bao, Weike, Nerurkar, Sandhya, Yue, Tian-Li, Doe, Chris P, Stankus, Gerald, Turner, Gregory H, Ju, Haisong, Thomas, Heath, Fishman, Cindy E, Sulpizio, Anthony, Behm, David J, Hoffman, Sandra, Lin, Zuojun, Lozinskaya, Irina, Casillas, Linda N, Lin, Min, Trout, Robert E Lee, Votta, Bartholomew J, Thorneloe, Kevin, Lashinger, Erin S R, Figueroa, David J, Marquis, Robert, Xu, Xiaoping

“…The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation channel that exhibits polymodal activation and is expressed in the…”
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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections by Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W, Hamrick, Jodie C, Daigle, Denis M, Cusick, Susan M, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J, Pevear, Daniel C, Xerri, Luigi, Burns, Christopher J

“…A major resistance mechanism in Gram-negative bacteria is the production of β-lactamase enzymes. Originally recognized for their ability to hydrolyze…”
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Spongipyran synthetic studies. Total synthesis of (+)-spongistatin 2 by Smith, Amos B., Lin, Qiyan, Doughty, Victoria A., Zhuang, Linghang, McBriar, Mark D., Kerns, Jeffrey K., Boldi, Armen M., Murase, Noriaki, Moser, William H., Brook, Christopher S., Bennett, Clay S., Nakayama, Kiyoshi, Sobukawa, Masao, Lee Trout, Robert E.

“…Evolution of a convergent synthetic strategy to access (+)-spongistatin 2 ( 2), a potent cytotoxic marine macrolide, is described. Highlights of the synthesis…”
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Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues by Marquis, Robert W, Lago, Amparo M, Callahan, James F, Trout, Robert E. Lee, Gowen, Maxine, DelMar, Eric G, Van Wagenen, Bradford C, Logan, Sarah, Shimizu, Scott, Fox, John, Nemeth, Edward F, Yang, Zheng, Roethke, Theresa, Smith, Brian R, Ward, Keith W, Lee, John, Keenan, Richard M, Bhatnagar, Pradip

“…Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino…”
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Azepanone-Based Inhibitors of Human Cathepsin L by Marquis, Robert W, James, Ian, Zeng, Jin, Trout, Robert E. Lee, Thompson, Scott, Rahman, Attiq, Yamashita, Dennis S, Xie, Ren, Ru, Yu, Gress, Catherine J, Blake, Simon, Lark, Michael A, Hwang, Shing-Mei, Tomaszek, Thaddeus, Offen, Priscilla, Head, Martha S, Cummings, Maxwell D, Veber, Daniel F

“…The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the…”
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Spongistatin synthetic studies. 2. Assembly of the C(18–28) spiroketal by Smith, Amos B., Zhuang, Linghang, Brook, Christopher S., Lin, Qiyan, Moser, William H., Lee Trout, Robert E., Boldi, Armen M.

“…The C(18–28) CD-ring spiroketal subunit of the spongistatins, marine polyether macrolides with unprecedented antitumor activity, has been generated via a…”
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Asymmetric synthesis of a potent azepanone-based inhibitor of the cysteine protease cathepsin K by Lee Trout, Robert E., Marquis, Robert W.

“…[Display omitted] In this account we detail the asymmetric synthesis of 1, a potent azepanone-based inhibitor of cathepsin K ( K i = 0.16 nM), which has been…”
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Spongipyran synthetic studies. Total synthesis of (+)-spongistatin 2: 2008 Tetrahedron Prize for Creativity in Organic Chemistry. The Art of Synthesis: Methods, Strategies and Applications by SMITH, Amos B, QIYAN LIN, BENNETT, Clay S, NAKAYAMA, Kiyoshi, SOBUKAWA, Masao, LEE TROUT, Robert E, DOUGHTY, Victoria A, LINGHANG ZHUANG, MCBRIAR, Mark D, KERNS, Jeffrey K, BOLDI, Armen M, MURASE, Noriaki, MOSER, William H, BROOK, Christopher S

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Cyclic Ketone Inhibitors of the Cysteine Protease Cathepsin K by Marquis, Robert W, Ru, Yu, Zeng, Jin, Trout, Robert E. Lee, LoCastro, Stephen M, Gribble, Andrew D, Witherington, Jason, Fenwick, Ashley E, Garnier, Benedicte, Tomaszek, Thaddeus, Tew, David, Hemling, Mark E, Quinn, Chad J, Smith, Ward W, Zhao, Baoguang, McQueney, Michael S, Janson, Cheryl A, D'Alessio, Karla, Veber, Daniel F

“…Cathepsin K (EC 3.4.22.38), a cysteine protease of the papain superfamily, is predominantly expressed in osteoclasts and has been postulated as a target for…”
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