Search Results - "Trousil, Jiří"

Biogenic and biomimetic nanocarrier-based interventions: focus on intracellular infections by Trousil, Jiří, Aryal, Santosh, Fuhrmann, Gregor

Get full text

Effect of Nanoparticle Weight on the Cellular Uptake and Drug Delivery Potential of PLGA Nanoparticles by Kattel, Prabhat, Sulthana, Shoukath, Trousil, Jiří, Shrestha, Dinesh, Pearson, David, Aryal, Santosh

“…Biodegradable and biocompatible polymeric nanoparticles (NPs) stand out as a key tool for improving drug bioavailability, reducing the inherent toxicity, and…”
Get full text

Chitosan-graft-poly(methyl methacrylate) amphiphilic nanoparticles: Self-association and physicochemical characterization by Schlachet, Inbar, Trousil, Jiří, Rak, Dmytro, Knudsen, Kenneth D., Pavlova, Ewa, Nyström, Bo, Sosnik, Alejandro

“…•We report on the self-assembly of a chitosan-poly(methyl methacrylate) copolymer.•Self-assembly forms water-swollen nanoparticles with Dh of 150–200…”
Get full text

Self-assembly and nanostructure of poly(vinyl alcohol)-graft-poly(methyl methacrylate) amphiphilic nanoparticles by Halamish, Hen Moshe, Trousil, Jiří, Rak, Dmytro, Knudsen, Kenneth D., Pavlova, Ewa, Nyström, Bo, Štěpánek, Petr, Sosnik, Alejandro

“…[Display omitted] Poly(vinyl alcohol)-g-poly(methyl methacrylate) (PVA-g-PMMA) amphiphilic copolymers self-assemble to form multi-micellar colloidal systems. A…”
Get full text

Rifampicin Nanoformulation Enhances Treatment of Tuberculosis in Zebrafish by Trousil, Jiří, Syrová, Zdeňka, Dal, Nils-Jørgen K, Rak, Dmytro, Konefał, Rafał, Pavlova, Ewa, Matějková, Jana, Cmarko, Dušan, Kubíčková, Pavla, Pavliš, Oto, Urbánek, Tomáš, Sedlák, Marián, Fenaroli, Federico, Raška, Ivan, Štěpánek, Petr, Hrubý, Martin

“…Mycobacterium tuberculosis, the etiologic agent of tuberculosis, is an intracellular pathogen of alveolar macrophages. These cells avidly take up…”
Get full text

Protein coronas coating polymer-stabilized silver nanocolloids attenuate cytotoxicity with minor effects on antimicrobial performance by Batista, Carin C.S., Panico, Karine, Trousil, Jiří, Janoušková, Olga, de Castro, Carlos Eduardo, Štěpánek, Petr, Giacomelli, Fernando C.

“…Silver nanoparticles are versatile platforms with a variety of applications in the biomedical field. In this framework, their presence in biological media…”
Get full text

Antitubercular nanocarrier monotherapy: Study of In Vivo efficacy and pharmacokinetics for rifampicin by Trousil, Jiří, Pavliš, Oto, Kubíčková, Pavla, Škorič, Miša, Marešová, Věra, Pavlova, Ewa, Knudsen, Kenneth D., Dai, You-Shan, Zimmerman, Matthew, Dartois, Véronique, Fang, Jia-You, Hrubý, Martin

“…Tuberculosis represents a major global health problem for which improved approaches are needed to shorten the course of treatment and to combat the emergence…”
Get full text

Antibiotic‐Loaded Amphiphilic Chitosan Nanoparticles Target Macrophages and Kill an Intracellular Pathogen by Trousil, Jiří, Dal, Nils‐Jørgen K., Fenaroli, Federico, Schlachet, Inbar, Kubíčková, Pavla, Janoušková, Olga, Pavlova, Ewa, Škorič, Miša, Trejbalová, Kateřina, Pavliš, Oto, Sosnik, Alejandro

“…In this work, levofloxacin (LVX), a third‐generation fluoroquinolone antibiotic, is encapsulated within amphiphilic polymeric nanoparticles of a…”
Get full text

Development of Smart Sensing Film with Nonbiofouling Properties for Potentiometric Detection of Local pH Changes Caused by Bacterial and Yeast Infections Around Orthopedic Implants by Tomšík, Elena, Gunár, Kristýna, Krunclová, Tereza, Ivanko, Iryna, Trousil, Jiří, Fojt, Jaroslav, Hybášek, Vojtěch, Daniel, Matej, Sepitka, Josef, Judl, Tobiaš, Jahoda, David, Hrubý, Martin

“…The local peri‐implant pH changes caused by sterile inflammation and bacterial and fungal infections are studied herein. Then, a sensing electrode based on…”
Get full text

Poly[2-(dimethylamino)ethyl methacrylate--ethylene dimethacrylate]nanogel by dispersion polymerization for inhibition of pathogenic bacteria by Šálek, Petr, Trousil, Ji í, Nová ková, Jitka, Hromádková, Ji ina, Mahun, Andrii, Kobera, Libor

“…Bacterial infections and antimicrobial resistance are one of the major public health problems and various strategies to prevent potential threats have been…”
Get full text

Fluorine-Containing Block and Gradient Copoly(2-oxazoline)s Based on 2‑(3,3,3-Trifluoropropyl)-2-oxazoline: A Quest for the Optimal Self-Assembled Structure for 19F Imaging by Kaberov, Leonid I, Kaberova, Zhansaya, Murmiliuk, Anastasiia, Trousil, Jiří, Sedláček, Ondřej, Konefal, Rafal, Zhigunov, Alexander, Pavlova, Ewa, Vít, Martin, Jirák, Daniel, Hoogenboom, Richard, Filippov, Sergey K

“…The use of fluorinated contrast agents in magnetic resonance imaging (MRI) facilitates improved image quality due to the negligible amount of endogenous…”
Get full text

Polymer-Antimicrobial Peptide Constructs with Tailored Drug-Release Behavior by Pola, Robert, Vícha, Matěj, Trousil, Jiří, Grosmanová, Eliška, Pechar, Michal, Rumlerová, Anna, Studenovský, Martin, Kučerová, Emilie, Ulbrich, Pavel, Vokatá, Barbora, Etrych, Tomáš

“…Microbial resistance is one of the main problems of modern medicine. Recently, antimicrobial peptides have been recognized as a novel approach to overcome the…”
Get full text

Fluorescence & bioluminescence in the quest for imaging, probing & analysis of mycobacterial infections by Trousil, Ji í, Ulmann, Vít, Hrubý, Martin

“…Mycobacterioses represent a global health problem and rapid diagnostic improvements are urgently required. Mycobacteria-specific fluorescence and…”
Get full text

Electrospun poly(l-lactide-co-dl-lactide) nanofibrous scaffold as substrate for ex vivo limbal epithelial cell cultivation by Trousil, Jiří, Cabral, Joao Victor, Voukali, Eleni, Nováčková, Jitka, Pop-Georgievski, Ognen, Vacík, Tomáš, Studený, Pavel, Studenovska, Hana, Jirsova, Katerina

“…Ultrathin electrospun poly (l-lactide-co-dl-lactide) nanofibrous membranes coated with fibronectin were explored as scaffolds for the ex vivo cultivation of…”
Get full text

γ‐Butyrolactone Copolymerization with the Well‐Documented Polymer Drug Carrier Poly(ethylene oxide)‐block‐poly(ε‐caprolactone) to Fine‐Tune Its Biorelevant Properties by Urbánek, Tomáš, Trousil, Jiří, Rak, Dmytro, Gunár, Kristýna, Konefał, Rafał, Šlouf, Miroslav, Sedlák, Marián, Šebestová Janoušková, Olga, Hrubý, Martin

“…Polymeric drug carriers exhibit excellent properties that advance drug delivery systems. In particular, carriers based on poly(ethylene…”
Get full text

Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation by Tsai, Ming-Jun, Lin, Cheng-Yu, Trousil, Jiří, Sung, Calvin T, Lee, Mei-Hua, Fang, Jia-You, Yang, Shih-Chun

“…Simultaneous anti- and anti-inflammatory actions are highly beneficial in treating acne vulgaris. In this study, we present novel anti-acne nanovesicles based…”
Get full text

System with Embedded Drug Release and Nanoparticle Degradation Sensor Showing Efficient Rifampicin Delivery into Macrophages by Trousil, Jiří, Filippov, Sergey K, Hrubý, Martin, Mazel, Tomáš, Syrová, Zdeňka, Cmarko, Dušan, Svidenská, Silvie, Matějková, Jana, Kováčik, Lubomír, Porsch, Bedřich, Konefał, Rafał, Lund, Reidar, Nyström, Bo, Raška, Ivan, Štěpánek, Petr

“…Abstract We have developed a biodegradable, biocompatible system for the delivery of antituberculotic antibiotic rifampicin with a built-in drug release and…”
Get full text

Novel nanoparticle delivery systems for rifampicin: an effective strategy against tuberculosis? by Trousil, Ji í, Hrubý, Martin

“…Even with this cocktail-based 6-9 months therapy, however, the evolution of drug-resistant mutants is enhanced due to poor patient compliance with treatment,…”
Get full text

Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation by Lin, Zih-Chan, Hwang, Tsong-Long, Huang, Tse-Hung, Tahara, Kohei, Trousil, Jiří, Fang, Jia-You

“…To improve the treatment of psoriasiform inflammation, we developed actively targeted nanocarriers loaded with the phosphodiesterase 4 inhibitor AN2728…”
Get full text

Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice by Trousil, Jiří, Frgelecová, Lucia, Kubíčková, Pavla, Řeháková, Kristína, Drašar, Vladimír, Matějková, Jana, Štěpánek, Petr, Pavliš, Oto

“…Legionnaires' disease is a severe form of lung infection caused by bacteria belonging to the genus . The disease severity depends on both host immunity and…”
Get full text