Search Results - "Trougakos, Ioannis"

Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance by Neophytou, Christiana M., Trougakos, Ioannis P., Erin, Nuray, Papageorgis, Panagiotis

“…The ability of tumor cells to evade apoptosis is established as one of the hallmarks of cancer. The deregulation of apoptotic pathways conveys a survival…”
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Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis by Trougakos, Ioannis P., Terpos, Evangelos, Alexopoulos, Harry, Politou, Marianna, Paraskevis, Dimitrios, Scorilas, Andreas, Kastritis, Efstathios, Andreakos, Evangelos, Dimopoulos, Meletios A.

“…Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19) pandemic, and mRNA vaccines are central to the ongoing vaccination campaign…”
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The molecular chaperone apolipoprotein J/clusterin as a sensor of oxidative stress: implications in therapeutic approaches - a mini-review by Trougakos, Ioannis P

“…Organisms are constantly exposed to physiological and environmental stresses and therefore require an efficient surveillance of genome and proteome quality in…”
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Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications by Trougakos, Ioannis P, Stamatelopoulos, Kimon, Terpos, Evangelos, Tsitsilonis, Ourania E, Aivalioti, Evmorfia, Paraskevis, Dimitrios, Kastritis, Efstathios, Pavlakis, George N, Dimopoulos, Meletios A

“…Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments…”
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Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and identification of putative modulators by Gkogkou, Eirini, Barnasas, Grigoris, Vougas, Konstantinos, Trougakos, Ioannis P.

“…Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in hundreds of thousands of…”
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Low neutralizing antibody responses against SARS-CoV-2 in older patients with myeloma after the first BNT162b2 vaccine dose by Terpos, Evangelos, Trougakos, Ioannis P., Gavriatopoulou, Maria, Papassotiriou, Ioannis, Sklirou, Aimilia D., Ntanasis-Stathopoulos, Ioannis, Papanagnou, Eleni-Dimitra, Fotiou, Despina, Kastritis, Efstathios, Dimopoulos, Meletios A.

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Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients by Bergamaschi, Cristina, Terpos, Evangelos, Rosati, Margherita, Angel, Matthew, Bear, Jenifer, Stellas, Dimitris, Karaliota, Sevasti, Apostolakou, Filia, Bagratuni, Tina, Patseas, Dimitris, Gumeni, Sentiljana, Trougakos, Ioannis P., Dimopoulos, Meletios A., Felber, Barbara K., Pavlakis, George N.

“…Early responses to vaccination are important for shaping both humoral and cellular protective immunity. Dissecting innate vaccine signatures may predict…”
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The emergence of drug resistance to targeted cancer therapies: Clinical evidence by Sarmento-Ribeiro, Ana Bela, Scorilas, Andreas, Gonçalves, Ana Cristina, Efferth, Thomas, Trougakos, Ioannis P.

“…For many decades classical anti-tumor therapies included chemotherapy, radiation and surgery; however, in the last two decades, following the identification of…”
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Molecular chaperones and proteostasis regulation during redox imbalance by Niforou, Katerina, Cheimonidou, Christina, Trougakos, Ioannis P

“…Free radicals originate from both exogenous environmental sources and as by-products of the respiratory chain and cellular oxygen metabolism. Sustained…”
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Nrf2, stress and aging by Trougakos, Ioannis P

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Natural compounds with anti-ageing activity by Argyropoulou, Aikaterini, Aligiannis, Nektarios, Trougakos, Ioannis P, Skaltsounis, Alexios-Leandros

“…Ageing is a complex molecular process driven by diverse molecular pathways and biochemical events that are promoted by both environmental and genetic factors…”
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Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance by Alves, Raquel, Gonçalves, Ana Cristina, Rutella, Sergio, Almeida, António M., De Las Rivas, Javier, Trougakos, Ioannis P., Sarmento Ribeiro, Ana Bela

“…Resistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade…”
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Age‐dependent and gender‐dependent antibody responses against SARS‐CoV‐2 in health workers and octogenarians after vaccination with the BNT162b2 mRNA vaccine by Terpos, Evangelos, Trougakos, Ioannis P., Apostolakou, Filia, Charitaki, Ioanna, Sklirou, Aimilia D., Mavrianou, Nefeli, Papanagnou, Eleni‐Dimitra, Liacos, Christine‐Ivy, Gumeni, Sentiljana, Rentziou, Gianna, Korompoki, Eleni, Papassotiriou, Ioannis, Dimopoulos, Meletios A.

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A Metabolomic Approach to Investigate the Effect of Phytonutrients on Proteostasis and Metabolic Pathways in Drosophila melanogaster by Mikropoulou, Eleni V, Evangelakou, Zoi, Trougakos, Ioannis P, Halabalaki, Maria

“…The use of as a biological platform to study the effect of diet and food bioactives on the metabolome remains a highly unexplored subject. Aiming to establish…”
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Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes by Gumeni, Sentiljana, Papanagnou, Eleni-Dimitra, Manola, Maria S., Trougakos, Ioannis P.

“…The balanced functionality of cellular proteostatic modules is central to both proteome stability and mitochondrial physiology; thus, the age-related decline…”
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Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin by Efentakis, Panagiotis, Kremastiotis, Georgios, Varela, Aimilia, Nikolaou, Panagiota-Efstathia, Papanagnou, Eleni-Dimitra, Davos, Constantinos H., Tsoumani, Maria, Agrogiannis, Georgios, Konstantinidou, Anastasia, Kastritis, Efstathios, Kanaki, Zoi, Iliodromitis, Efstathios K., Klinakis, Apostolos, Dimopoulos, Meletios A., Trougakos, Ioannis P., Andreadou, Ioanna, Terpos, Evangelos

“…Carfilzomib (Cfz), an irreversible proteasome inhibitor licensed for relapsed/refractory myeloma, is associated with cardiotoxicity in humans. We sought to…”
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What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg by Alexa-Stratulat, Teodora, Pešić, Milica, Gašparović, Ana Čipak, Trougakos, Ioannis P., Riganti, Chiara

“…Identification of multidrug (MDR) efflux transporters that belong to the ATP-Binding Cassette (ABC) superfamily, represented an important breakthrough for…”
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The Amazing Ubiquitin-Proteasome System: Structural Components and Implication in Aging by Tsakiri, Eleni N, Trougakos, Ioannis P

“…Proteome quality control (PQC) is critical for the maintenance of cellular functionality and it is assured by the curating activity of the proteostasis network…”
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Integrating the DNA damage and protein stress responses during cancer development and treatment by Gorgoulis, Vassilis G, Pefani, Dafni‐Eleftheria, Pateras, Ioannis S, Trougakos, Ioannis P

“…During evolution, cells have developed a wide spectrum of stress response modules to ensure homeostasis. The genome and proteome damage response pathways…”
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Proteome Stability as a Key Factor of Genome Integrity by Gumeni, Sentiljana, Evangelakou, Zoi, Gorgoulis, Vassilis G, Trougakos, Ioannis P

“…DNA damage is constantly produced by both endogenous and exogenous factors; DNA lesions then trigger the so-called DNA damaged response (DDR). This is a highly…”
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