Search Results - "Trottier, Magan"

Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer by Hamilton, Jada G., Symecko, Heather, Spielman, Kelsey, Breen, Kelsey, Mueller, Rebecca, Catchings, Amanda, Trottier, Magan, Salo-Mullen, Erin E., Shah, Ibrahim, Arutyunova, Anna, Batson, Melissa, Gebert, Rebecca, Pundock, Stacy, Schofield, Elizabeth, Offit, Kenneth, Stadler, Zsofia K., Cadoo, Karen, Carlo, Maria I., Narayan, Vivek, Reiss, Kim A., Robson, Mark E., Domchek, Susan M.

“…Purpose To address demands for timely germline information to guide treatments, we evaluated experiences of patients with ovarian, pancreatic, and prostate…”
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A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal by Milyavsky, Michael, Gan, Olga I., Trottier, Magan, Komosa, Martin, Tabach, Ofer, Notta, Faiyaz, Lechman, Eric, Hermans, Karin G., Eppert, Kolja, Konovalova, Zhanna, Ornatsky, Olga, Domany, Eytan, Meyn, M. Stephen, Dick, John E.

“…Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR) that balance long-term regeneration with protection from…”
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Treating constipation during pregnancy by Trottier, Magan, Erebara, Aida, Bozzo, Pina

“…Many of my patients experience constipation during pregnancy, even after increasing dietary fibre and fluids. Are there any safe treatments I can recommend to…”
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Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation by Biechonski, Shahar, Olender, Leonid, Zipin-Roitman, Adi, Yassin, Muhammad, Aqaqe, Nasma, Marcu-Malina, Victoria, Rall-Scharpf, Melanie, Trottier, Magan, Meyn, M. Stephen, Wiesmüller, Lisa, Beider, Katia, Raz, Yael, Grisaru, Dan, Nagler, Arnon, Milyavsky, Michael

“…Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote…”
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Genetics healthcare providers' experiences counseling patients with results from consumer genomic testing by Trottier, Magan, Green, Dina, Ovadia, Hannah, Catchings, Amanda, Gruberg, Julia, Groner, Victoria, Fanjoy, Catherine, Dandiker, Sita, Blazer, Kathleen, Hamilton, Jada G., Offit, Kenneth

“…Background Consumer genomic testing (CGT), including direct‐to‐consumer and consumer‐initiated testing, is increasingly widespread yet has limited regulatory…”
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Insertion of an Alu‐like element in MLH1 intron 7 as a novel cause of Lynch syndrome by Li, Yirong, Salo‐Mullen, Erin, Varghese, Anna, Trottier, Magan, Stadler, Zsofia K., Zhang, Liying

“…Background Lynch Syndrome (LS) is caused by germline mutations in the DNA mismatch repair (MMR) genes with mutations in MLH1 accounting for ~40% of LS‐related…”
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Response of human hematopoietic cells to DNA double-strand breaks by Trottier, Magan D

“…Maintenance of hematopoiesis depends upon rare hematopoietic stem cells (HSCs), which can persist over an organism's lifetime. It is conceivable that they must…”
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Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing by Mandelker, Diana, Zhang, Liying, Kemel, Yelena, Stadler, Zsofia K, Joseph, Vijai, Zehir, Ahmet, Pradhan, Nisha, Arnold, Angela, Walsh, Michael F, Li, Yirong, Balakrishnan, Anoop R, Syed, Aijazuddin, Prasad, Meera, Nafa, Khedoudja, Carlo, Maria I, Cadoo, Karen A, Sheehan, Meg, Fleischut, Megan H, Salo-Mullen, Erin, Trottier, Magan, Lipkin, Steven M, Lincoln, Anne, Mukherjee, Semanti, Ravichandran, Vignesh, Cambria, Roy, Galle, Jesse, Abida, Wassim, Arcila, Marcia E, Benayed, Ryma, Shah, Ronak, Yu, Kenneth, Bajorin, Dean F, Coleman, Jonathan A, Leach, Steven D, Lowery, Maeve A, Garcia-Aguilar, Julio, Kantoff, Philip W, Sawyers, Charles L, Dickler, Maura N, Saltz, Leonard, Motzer, Robert J, O’Reilly, Eileen M, Scher, Howard I, Baselga, José, Klimstra, David S, Solit, David B, Hyman, David M, Berger, Michael F, Ladanyi, Marc, Robson, Mark E, Offit, Kenneth

“…IMPORTANCE: Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for…”
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Regulation of Laboratory-Developed Tests in Preventive Oncology: Emerging Needs and Opportunities by Offit, Kenneth, Sharkey, Catherine M, Green, Dina, Wu, Xiaohan, Trottier, Magan, Hamilton, Jada G, Walsh, Michael F, Dandiker, Sita, Belhadj, Sami, Lipkin, Steven M, Sugrañes, Thelma Alessandra, Caggana, Michele, Stadler, Zsofia K

“…Cancer predictive or diagnostic assays, offered as Laboratory-Developed Tests (LDTs), have been subject to regulatory authority and enforcement discretion by…”
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Disparities in cancer genetics care by race/ethnicity among pan‐cancer patients with pathogenic germline variants by Liu, Ying L., Maio, Anna, Kemel, Yelena, Salo‐Mullen, Erin E., Sheehan, Margaret, Tejada, Prince Ray, Trottier, Magan, Arnold, Angela G., Fleischut, Megan Harlan, Latham, Alicia, Carlo, Maria I., Murciano‐Goroff, Yonina R., Walsh, Michael F., Mandelker, Diana, Mehta, Nikita, Bandlamudi, Chaitanya, Arora, Kanika, Zehir, Ahmet, Berger, Michael F., Solit, David B., Aghajanian, Carol, Diaz, Luis A., Robson, Mark E., Brown, Carol L., Offit, Kenneth, Hamilton, Jada G., Stadler, Zsofia K.

“…Background Germline risk assessment is increasing as part of cancer care; however, disparities in subsequent genetic counseling are unknown. Methods Pan‐cancer…”
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Outcomes of incidentally detected ovarian cancers diagnosed at time of risk-reducing salpingo-oophorectomy in BRCA mutation carriers by Cowan, Renee, Nobre, Silvana Pedra, Pradhan, Nisha, Yasukawa, Maya, Zhou, Qin C., Iasonos, Alexia, Soslow, Robert A., Arnold, Angela G., Trottier, Magan, Catchings, Amanda, Roche, Kara Long, Gardner, Ginger, Robson, Mark, Abu Rustum, Nadeem R., Aghajanian, Carol, Cadoo, Karen

“…Prior data suggested that women with incidentally detected occult invasive ovarian cancer (OIOC) at the time of risk-reducing salpingo-oophorectomy (RRSO) for…”
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Disparities in pan-cancer patients undergoing germline cancer risk assessment by self-reported race/ethnicity and ancestry by Liu, Ying L, Maio, Anna, Kemel, Yelena, Salo-Mullen, Erin E., Sheehan, Margaret, Tejada, Prince Rainier, Trottier, Magan, Harlan Fleischut, Megan, Latham, Alicia, Carlo, Maria Isabel, Walsh, Michael Francis, Robson, Mark E., Mandelker, Diana, Diaz, Luis A., Aghajanian, Carol, Brown, Carol L., Offit, Kenneth, Hamilton, Jada G., Stadler, Zsofia Kinga

“…Abstract only 10508 Background: Disparities in access to germline testing for cancer patients (pts) have been demonstrated; however, disparities in…”
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Insertion of an SVA element in MSH2 as a novel cause of Lynch syndrome by Yang, Ciyu, Li, Yirong, Trottier, Magan, Farrell, Michael P., Rai, Vikas K., Salo‐Mullen, Erin, Gallagher, David J., Stadler, Zsofia K., van der Klift, Heleen M., Zhang, Liying

“…Germline mutations in the DNA mismatch repair (MMR) genes cause Lynch syndrome (LS). In this study, we identified and characterized a novel SINE‐VNTR‐Alu (SVA)…”
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Fanconi Anemia and the Response of Human Hematopoietic Cells to DNA Damage by Trottier, Magan, Meyn, Stephen

“…Given their critical role in the generation and renewal of the hematopoietic system, we hypothesize that hematopoietic stem and primitive cells employ…”
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Parents’ Perspectives on Participating in Genetic Research in Autism by Trottier, Magan, Roberts, Wendy, Drmic, Irene, Scherer, Stephen W., Weksberg, Rosanna, Cytrynbaum, Cheryl, Chitayat, David, Shuman, Cheryl, Miller, Fiona A.

“…Genetic research in autism depends on the willingness of individuals with autism to participate; thus, there is a duty to assess participants’ needs in the…”
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Whole-Genome Analysis and HLA Genotyping of Enteropathy-Type T-Cell Lymphoma Reveals 2 Distinct Lymphoma Subtypes by deLeeuw, Ronald J, Zettl, Andreas, Klinker, Erdwine, Haralambieva, Eugenia, Trottier, Magan, Chari, Raj, Ge, Yong, Gascoyne, Randy D, Chott, Andreas, Müller–Hermelink, Hans–Konrad, Lam, Wan L

“…Background & Aims: Enteropathy-type T-cell lymphoma (ETL) is an aggressive extranodal T-cell non-Hodgkin lymphoma assumed to arise in the setting of celiac…”
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Characterization of a novel germline PALB2 duplication in a hereditary breast and ovarian cancer family by Yang, Ciyu, Arnold, Angela G., Trottier, Magan, Sonoda, Yukio, Abu-Rustum, Nadeem R., Zivanovic, Oliver, Robson, Mark E., Stadler, Zsofia K., Walsh, Michael F., Hyman, David M., Offit, Kenneth, Zhang, Liying

“…Purpose Mutations in PALB2 have been associated with a predisposition to breast and pancreatic cancers. This study aims to characterize a novel PALB2 exon 13…”
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Clinical characterization of DNA mismatch repair deficiency (MMR-D) in endometrial cancer (EC) by Cadoo, Karen Anne, Tran, Christina, DeLair, Deborah, Arnold, Angela G., Ashraf, Asad, Jewell, Elizabeth Lin, Kauff, Noah D., Long, Kara, Mueller, Jennifer Jean, Robson, Mark E., Schiavone, Maria, Trottier, Magan, Soslow, Robert A., Offit, Kenneth, Aghajanian, Carol, Stadler, Zsofia Kinga

“…Abstract only…”
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Feasibility and long-term utility of a psychosocial support group for patients with Lynch syndrome by Tran, Christina, Hamilton, Jada G, Lincoln, Anne, Corines, Marina, Musinsky, Jacob, Gaddam, Pragna, Jacobs, Lauren M, Glogowski, Emily, Anrig, Christopher, Goldberg, Rachael, Ashraf, Asad, Salo-Mullen, Erin E., Harlan Fleischut, Megan, Sheehan, Margaret, Trottier, Magan, Offit, Kenneth, Stadler, Zsofia Kinga

“…Abstract only…”
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Somatic tumor profiling of DNA mismatch repair (MMR) deficient endometrial cancers (EC) by Cadoo, Karen Anne, DeLair, Deborah, Mandelker, Diana, Trottier, Magan, Stewart, Carolyn, Tran, Christina, Kemel, Yelena, Walsh, Michael Francis, Scharf, Felicia, Hyman, David Michael, Joseph, Vijai, Robson, Mark E., Abu-Rustum, Nadeem, Offit, Kenneth, Solit, David B., Berger, Michael F., Aghajanian, Carol, Stadler, Zsofia Kinga

“…Abstract only e17121 Background: Approximately 20% of EC have loss of MMR ( MSH2, MSH6, MLH1, PMS2) protein expression by immunohistochemistry (IHC). The…”
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