Search Results - "Trotman, Lloyd C"

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice by Albrengues, Jean, Shields, Mario A, Ng, David, Park, Chun Gwon, Ambrico, Alexandra, Poindexter, Morgan E, Upadhyay, Priya, Uyeminami, Dale L, Pommier, Arnaud, Küttner, Victoria, Bružas, Emilis, Maiorino, Laura, Bautista, Carmelita, Carmona, Ellese M, Gimotty, Phyllis A, Fearon, Douglas T, Chang, Kenneth, Lyons, Scott K, Pinkerton, Kent E, Trotman, Lloyd C, Goldberg, Michael S, Yeh, Johannes T-H, Egeblad, Mikala

“…Cancer cells from a primary tumor can disseminate to other tissues, remaining dormant and clinically undetectable for many years. Little is known about the…”
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Turning off AKT: PHLPP as a drug target by Newton, Alexandra C, Trotman, Lloyd C

“…Precise control of the balance between protein phosphorylation, catalyzed by protein kinases, and protein dephosphorylation, catalyzed by protein phosphatases,…”
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Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization by Senturk, Serif, Shirole, Nitin H., Nowak, Dawid G., Corbo, Vincenzo, Pal, Debjani, Vaughan, Alexander, Tuveson, David A., Trotman, Lloyd C., Kinney, Justin B., Sordella, Raffaella

“…The CRISPR/Cas9 system is a powerful tool for studying gene function. Here, we describe a method that allows temporal control of CRISPR/Cas9 activity based on…”
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Subtle variations in Pten dose determine cancer susceptibility by Alimonti, Andrea, Carracedo, Arkaitz, Nardella, Caterina, Sampieri, Katia, Richardson, Andrea L, Brogi, Edi, Pandolfi, Pier Paolo, Haveman, William J, Egia, Ainara, Zhang, Jiangwen, Trotman, Lloyd C, Salmena, Leonardo, Clohessy, John G

“…Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG). It has been hypothesized that…”
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SOAT1 promotes mevalonate pathway dependency in pancreatic cancer by Oni, Tobiloba E, Biffi, Giulia, Baker, Lindsey A, Hao, Yuan, Tonelli, Claudia, Somerville, Tim D D, Deschênes, Astrid, Belleau, Pascal, Hwang, Chang-Il, Sánchez-Rivera, Francisco J, Cox, Hilary, Brosnan, Erin, Doshi, Abhishek, Lumia, Rebecca P, Khaledi, Kimia, Park, Youngkyu, Trotman, Lloyd C, Lowe, Scott W, Krasnitz, Alexander, Vakoc, Christopher R, Tuveson, David A

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. Altered metabolism is a cancer vulnerability, and several…”
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PTEN functions by recruitment to cytoplasmic vesicles by Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R., Jaber, Nadia, Pratt, Christopher P., Chen, Muhan, Zong, Wei-Xing, Marks, Michael S., Joshua-Tor, Leemor, Pappin, Darryl J., Trotman, Lloyd C.

“…PTEN is proposed to function at the plasma membrane, where receptor tyrosine kinases are activated. Yet, the majority of PTEN is located throughout the…”
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Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth by Carbonetti, Gregory, Converso, Cynthia, Clement, Timothy, Wang, Changwei, Trotman, Lloyd C, Ojima, Iwao, Kaczocha, Martin

“…Background Prostate cancer (PCa) remains the second leading cause of cancer‐related death among men. Taxanes, such as docetaxel and cabazitaxel are utilized in…”
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Fatty acid binding protein 5 regulates docetaxel sensitivity in taxane-resistant prostate cancer cells by Hillowe, Andrew, Gordon, Chris, Wang, Liqun, Rizzo, Robert C, Trotman, Lloyd C, Ojima, Iwao, Bialkowska, Agnieszka, Kaczocha, Martin

“…Prostate cancer is a leading cause of cancer-related deaths in men in the United States. Although treatable when detected early, prostate cancer commonly…”
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Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression by Chen, Muhan, Pratt, Christopher P., Zeeman, Martha E., Schultz, Nikolaus, Taylor, Barry S., O'Neill, Audrey, Castillo-Martin, Mireia, Nowak, Dawid G., Naguib, Adam, Grace, Danielle M., Murn, Jernej, Navin, Nick, Atwal, Gurinder S., Sander, Chris, Gerald, William L., Cordon-Cardo, Carlos, Newton, Alexandra C., Carver, Brett S., Trotman, Lloyd C.

“…Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor…”
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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells by Naguib, Adam, Mathew, Grinu, Reczek, Colleen R., Watrud, Kaitlin, Ambrico, Alexandra, Herzka, Tali, Salas, Irene Casanova, Lee, Matthew F., El-Amine, Nour, Zheng, Wu, Di Francesco, M. Emilia, Marszalek, Joseph R., Pappin, Darryl J., Chandel, Navdeep S., Trotman, Lloyd C.

“…A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic…”
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NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN by Wang, Xinjiang, Trotman, Lloyd C., Koppie, Theresa, Alimonti, Andrea, Chen, Zhenbang, Gao, Zhonghua, Wang, Junru, Erdjument-Bromage, Hediye, Tempst, Paul, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo, Jiang, Xuejun

“…The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions…”
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Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression by Trotman, Lloyd C., Wang, Xinjiang, Alimonti, Andrea, Chen, Zhenbang, Teruya-Feldstein, Julie, Yang, Haijuan, Pavletich, Nikola P., Carver, Brett S., Cordon-Cardo, Carlos, Erdjument-Bromage, Hediye, Tempst, Paul, Chi, Sung-Gil, Kim, Hyo-Jong, Misteli, Tom, Jiang, Xuejun, Pandolfi, Pier Paolo

“…The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome…”
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P53 Mutations Change Phosphatidylinositol Acyl Chain Composition by Naguib, Adam, Bencze, Gyula, Engle, Dannielle D., Chio, Iok I.C., Herzka, Tali, Watrud, Kaitlin, Bencze, Szilvia, Tuveson, David A., Pappin, Darryl J., Trotman, Lloyd C.

“…Phosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal…”
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PTEN regulation of local and long-range connections in mouse auditory cortex by Xiong, Qiaojie, Oviedo, Hysell V, Trotman, Lloyd C, Zador, Anthony M

“…Autism spectrum disorders (ASDs) are highly heritable developmental disorders caused by a heterogeneous collection of genetic lesions. Here we use a mouse…”
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MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2 by Nowak, Dawid G, Cho, Hyejin, Herzka, Tali, Watrud, Kaitlin, DeMarco, Daniel V, Wang, Victoria M Y, Senturk, Serif, Fellmann, Christof, Ding, David, Beinortas, Tumas, Kleinman, David, Chen, Muhan, Sordella, Raffaella, Wilkinson, John E, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Robinson, Brian D, Trotman, Lloyd C

“…We have recently recapitulated metastasis of human PTEN/TP53-mutant prostate cancer in the mouse using the RapidCaP system. Surprisingly, we found that this…”
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Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia by Howitt, Jason, Lackovic, Jenny, Low, Ley-Hian, Naguib, Adam, Macintyre, Alison, Goh, Choo-Peng, Callaway, Jennifer K, Hammond, Vicki, Thomas, Tim, Dixon, Matthew, Putz, Ulrich, Silke, John, Bartlett, Perry, Yang, Baoli, Kumar, Sharad, Trotman, Lloyd C, Tan, Seong-Seng

“…PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the major negative regulator of phosphatidylinositol 3-kinase signaling and has…”
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Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases by Taranda, Julian, Mathew, Grinu, Watrud, Kaitlin, El-Amine, Nour, Lee, Matthew F., Elowsky, Corey, Bludova, Anastasiia, Escobar Avelar, Sintia, Nowak, Dawid G., Wee, Tse-Luen, Wilkinson, John E., Trotman, Lloyd C., Osten, Pavel

“…Early steps of cancer initiation and metastasis, while critical for understanding disease mechanisms, are difficult to visualize and study. Here, we describe…”
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SUMO Modification of Huntingtin and Huntington'S Disease Pathology by Steffan, Joan S., Agrawal, Namita, Pallos, Judit, Rockabrand, Erica, Trotman, Lloyd C., Slepko, Natalia, Illes, Katalin, Lukacsovich, Tamas, Zhu, Ya-Zhen, Cattaneo, Elena, Pandolfi, Pier Paolo, Thompson, Leslie Michels, Marsh, J. Lawrence

“…Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein, Huntingtin (Htt), that contains an abnormal polyglutamine expansion…”
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Pten dose dictates cancer progression in the prostate by Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, Khoo, Alan S, Roy-Burman, Pradip, Greenberg, Norman M, Van Dyke, Terry, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo

“…Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is…”
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PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers by Labbé, David P, Uetani, Noriko, Vinette, Valérie, Lessard, Laurent, Aubry, Isabelle, Migon, Eva, Sirois, Jacinthe, Haigh, Jody J, Bégin, Louis R, Trotman, Lloyd C, Paquet, Marilène, Tremblay, Michel L

“…Diet affects the risk and progression of prostate cancer, but the interplay between diet and genetic alterations in this disease is not understood. Here we…”
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