Search Results - "Trost, Brett"

Computational prediction of eukaryotic phosphorylation sites by Trost, Brett, Kusalik, Anthony

“…Motivation: Kinase-mediated phosphorylation is the central mechanism of post-translational modification to regulate cellular responses and phenotypes…”
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Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease by Wright, Galen E.B., Collins, Jennifer A., Kay, Chris, McDonald, Cassandra, Dolzhenko, Egor, Xia, Qingwen, Bečanović, Kristina, Drögemöller, Britt I., Semaka, Alicia, Nguyen, Charlotte M., Trost, Brett, Richards, Fiona, Bijlsma, Emilia K., Squitieri, Ferdinando, Ross, Colin J.D., Scherer, Stephen W., Eberle, Michael A., Yuen, Ryan K.C., Hayden, Michael R.

“…Huntington disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Although the length of this repeat is inversely correlated with age…”
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ExpansionHunter Denovo: a computational method for locating known and novel repeat expansions in short-read sequencing data by Dolzhenko, Egor, Bennett, Mark F, Richmond, Phillip A, Trost, Brett, Chen, Sai, van Vugt, Joke J F A, Nguyen, Charlotte, Narzisi, Giuseppe, Gainullin, Vladimir G, Gross, Andrew M, Lajoie, Bryan R, Taft, Ryan J, Wasserman, Wyeth W, Scherer, Stephen W, Veldink, Jan H, Bentley, David R, Yuen, Ryan K C, Bahlo, Melanie, Eberle, Michael A

“…Repeat expansions are responsible for over 40 monogenic disorders, and undoubtedly more pathogenic repeat expansions remain to be discovered. Existing methods…”
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Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome by McDonald, Megan, Trost, Brett, Napper, Scott

“…Kinase-mediated protein phosphorylation is a central mechanism for regulation of cellular responses and phenotypes. While considerable information is available…”
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Transcriptome analysis of response to Plasmodiophora brassicae infection in the Arabidopsis shoot and root by Irani, Solmaz, Trost, Brett, Waldner, Matthew, Nayidu, Naghabushana, Tu, Jiangying, Kusalik, Anthony J, Todd, Christopher D, Wei, Yangdou, Bonham-Smith, Peta C

“…Clubroot is an important disease caused by the obligate parasite Plasmodiophora brassicae that infects the Brassicaceae. As a soil-borne pathogen, P. brassicae…”
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Genome-wide tandem repeat expansions contribute to schizophrenia risk by Mojarad, Bahareh A., Engchuan, Worrawat, Trost, Brett, Backstrom, Ian, Yin, Yue, Thiruvahindrapuram, Bhooma, Pallotto, Linda, Mitina, Aleksandra, Khan, Mahreen, Pellecchia, Giovanna, Haque, Bushra, Guo, Keyi, Heung, Tracy, Costain, Gregory, Scherer, Stephen W., Marshall, Christian R., Pearson, Christopher E., Bassett, Anne S., Yuen, Ryan K. C.

“…Tandem repeat expansions (TREs) can cause neurological diseases but their impact in schizophrenia is unclear. Here we analyzed genome sequences of adults with…”
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PIIKA 2: an expanded, web-based platform for analysis of kinome microarray data by Trost, Brett, Kindrachuk, Jason, Määttänen, Pekka, Napper, Scott, Kusalik, Anthony

“…Kinome microarrays are comprised of peptides that act as phosphorylation targets for protein kinases. This platform is growing in popularity due to its ability…”
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Computational Analysis of the Predicted Evolutionary Conservation of Human Phosphorylation Sites by Trost, Brett, Kusalik, Anthony, Napper, Scott

“…Protein kinase-mediated phosphorylation is among the most important post-translational modifications. However, few phosphorylation sites have been…”
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DAPPLE: a pipeline for the homology-based prediction of phosphorylation sites by Trost, Brett, Arsenault, Ryan, Griebel, Philip, Napper, Scott, Kusalik, Anthony

“…While many experimentally characterized phosphorylation sites exist for certain organisms, such as human, rat and mouse, few sites are known for other…”
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Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics by Lok, Si, Lau, Timothy N. H., Trost, Brett, Tong, Amy H. Y., Paton, Tara, Wintle, Richard F., Engstrom, Mark D., Gunn, Anne, Scherer, Stephen W.

“…The muskox ( Ovibos moschatus ), an integral component and iconic symbol of arctic biocultural diversity, is under threat by rapid environmental disruptions…”
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Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions by Ramirez, Miguel, Badayeva, Yuliya, Yeung, Joanna, Wu, Joshua, Abdalla-Wyse, Ayasha, Yang, Erin, Trost, Brett, Scherer, Stephen W, Goldowitz, Daniel

“…We have identified active enhancers in the mouse cerebellum at embryonic and postnatal stages which provides a view of novel enhancers active during cerebellar…”
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Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder by Chan, Ada J. S., Engchuan, Worrawat, Reuter, Miriam S., Wang, Zhuozhi, Thiruvahindrapuram, Bhooma, Trost, Brett, Nalpathamkalam, Thomas, Negrijn, Carol, Lamoureux, Sylvia, Pellecchia, Giovanna, Patel, Rohan V., Sung, Wilson W. L., MacDonald, Jeffrey R., Howe, Jennifer L., Vorstman, Jacob, Sondheimer, Neal, Takahashi, Nicole, Miles, Judith H., Anagnostou, Evdokia, Tammimies, Kristiina, Zarrei, Mehdi, Merico, Daniele, Stavropoulos, Dimitri J., Yuen, Ryan K. C., Fernandez, Bridget A., Scherer, Stephen W.

“…Defining different genetic subtypes of autism spectrum disorder (ASD) can enable the prediction of developmental outcomes. Based on minor physical and major…”
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Induction of tissue- and stressor-specific kinomic responses in chickens exposed to hot and cold stresses by Napper, Scott, Dadgar, Samira, Arsenault, Ryan J., Trost, Brett, Scruten, Erin, Kusalik, Anthony, Shand, Phyllis

“…Defining cellular responses at the level of global cellular kinase (kinome) activity is a powerful approach to deciphering complex biology and identifying…”
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Divergent Immune Responses to Mycobacterium avium subsp. paratuberculosis Infection Correlate with Kinome Responses at the Site of Intestinal Infection by Määttänen, Pekka, Trost, Brett, Scruten, Erin, Potter, Andrew, Kusalik, Anthony, Griebel, Philip, Napper, Scott

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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An Epigenetically Distinct Subset of Children With Autism Spectrum Disorder Resulting From Differences in Blood Cell Composition by Jangjoo, Maryam, Goodman, Sarah J, Choufani, Sanaa, Trost, Brett, Scherer, Stephen W, Kelley, Elizabeth, Ayub, Muhammad, Nicolson, Rob, Georgiades, Stelios, Crosbie, Jennifer, Schachar, Russell, Anagnostou, Evdokia, Grunebaum, Eyal, Weksberg, Rosanna

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that often involves impaired cognition, communication difficulties and restrictive,…”
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Investigation of the cause of geographic disparities in IDEXX ELISA sensitivity in serum samples from Mycobacterium bovis-infected cattle by Trost, Brett, Stuber, Tod, Surujballi, Om, Nelson, Jeffrey, Robbe-Austerman, Suelee, Smith, Noel H., Desautels, Louis, Tikoo, Suresh K., Griebel, Philip

“…Accurately identifying Mycobacterium bovis -infected cattle is critical for bovine tuberculosis prevention and control. One method for identifying infected…”
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Comparing the similarity of different groups of bacteria to the human proteome by Trost, Brett, Pajon, Rolando, Jayaprakash, Teenus, Kusalik, Anthony

“…Numerous aspects of the relationship between bacteria and human have been investigated. One aspect that has recently received attention is sequence overlap at…”
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Correction: PIIKA 2: An Expanded, Web-Based Platform for Analysis of Kinome Microarray Data by Trost, Brett, Kindrachuk, Jason, Määttänen, Pekka, Napper, Scott, Kusalik, Anthony

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A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder by Loureiro, Livia O., Howe, Jennifer L., Reuter, Miriam S., Iaboni, Alana, Calli, Kristina, Roshandel, Delnaz, Pritišanac, Iva, Moses, Alan, Forman-Kay, Julie D., Trost, Brett, Zarrei, Mehdi, Rennie, Olivia, Lau, Lynette Y. S., Marshall, Christian R., Srivastava, Siddharth, Godlewski, Brianna, Buttermore, Elizabeth D., Sahin, Mustafa, Hartley, Dean, Frazier, Thomas, Vorstman, Jacob, Georgiades, Stelios, Lewis, Suzanne M. E., Szatmari, Peter, Bradley, Clarrisa A. (Lisa), Tabet, Anne-Claude, Willems, Marjolaine, Lumbroso, Serge, Piton, Amélie, Lespinasse, James, Delorme, Richard, Bourgeron, Thomas, Anagnostou, Evdokia, Scherer, Stephen W.

“…Autism Spectrum Disorder (ASD) is genetically complex with ~100 copy number variants and genes involved. To try to establish more definitive genotype and…”
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Pentamers not found in the universal proteome can enhance antigen specific immune responses and adjuvant vaccines by Patel, Ami, Dong, Jessica C, Trost, Brett, Richardson, Jason S, Tohme, Sarah, Babiuk, Shawn, Kusalik, Anthony, Kung, Sam K P, Kobinger, Gary P

“…Certain short peptides do not occur in humans and are rare or non-existent in the universal proteome. Antigens that contain rare amino acid sequences are in…”
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