Dose Field Shaping and Biological Effectiveness of the Effect of Pulsed Electron Accelerator Novac-11 on Mammalian Cells

Dose Field Shaping and Biological Effectiveness of the Effect of Pulsed Electron Accelerator Novac-11 on Mammalian Cells

The development of technologies for using the Novac-11 pulsed electron accelerator in radiation therapy of animals with spontaneous neoplasms requires dosimetric and radiobiological studies. The studies were performed on cultured Chinese hamster V-79 fibroblasts after irradiation with 10 MeV electro...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 172; no. 5; pp. 558 - 560
Main Authors: Koryakina, E. V., Lychagin, A. A., Potetnya, V. I., Troshinа, M. V., Saburov, V. O., Moiseev, A. S., Koryakin, S. N., Ivanov, S. A., Shegai, P. V., Kaprin, A. D.
Format: Journal Article
Language:English
Published: New York Springer US 01-03-2022
Springer
Springer Nature B.V
Subjects:
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Cell survival
Cells
Electrons
Fibroblasts
Internal Medicine
Laboratory Medicine
Mammalian cells
Neoplasia
Pathology
Radiation
Radiation therapy
Radiotherapy
Technology application
Tumors
γ Radiation
Novac-11
chemical FBX and Fricke dosimeters
cell survival
electrons
V-79 cells
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The development of technologies for using the Novac-11 pulsed electron accelerator in radiation therapy of animals with spontaneous neoplasms requires dosimetric and radiobiological studies. The studies were performed on cultured Chinese hamster V-79 fibroblasts after irradiation with 10 MeV electrons in a dose range up to 12 Gy and 60 Co γ-radiation. Chemical dosimeters FBX and Fricke were used as additional test-systems. The depth dose curves were measured and the maximum dose depth of the electron beam was determined in tissue-equivalent phantoms. Cell survival and the data of chemical dosimetric systems showed that the effects of electron irradiation did not differ from that of 60 Co γ-radiation. It was concluded that the use of Novac-11 in the therapy of animals with spontaneous neoplasms is advisable.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05432-3