Search Results - "Troschel, Fabian M."

Low Thoracic Skeletal Muscle Area Predicts Morbidity After Pneumonectomy for Lung Cancer by Madariaga, Maria Lucia L., Troschel, Fabian M., Best, Till D., Knoll, Sheila J., Gaissert, Henning A., Fintelmann, Florian J.

“…Sarcopenia represented by low psoas muscle area is associated with increased hospital length of stay (LOS), postoperative complications, and mortality. We…”
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Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells by Löblein, Maria T, Falke, Isabel, Eich, Hans Theodor, Greve, Burkhard, Götte, Martin, Troschel, Fabian M

“…In ovarian cancer, therapy resistance mechanisms complicate cancer cell eradication. Targeting Musashi RNA-binding proteins (MSI) may increase therapeutic…”
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Significance of Acquisition Parameters for Adipose Tissue Segmentation on CT Images by Troschel, Amelie S, Troschel, Fabian M, Fuchs, Georg, Marquardt, J Peter, Ackman, Jeanne B, Yang, Kai, Fintelmann, Florian J

“…CT-based body composition analysis quantifies skeletal muscle and adipose tissue. However, acquisition parameters and quality can vary between CT images…”
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miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro by Troschel, Fabian M, Böhly, Nicolas, Borrmann, Katrin, Braun, Timo, Schwickert, Alexander, Kiesel, Ludwig, Eich, Hans Theodor, Götte, Martin, Greve, Burkhard

“…Effectively targeting cancer stem cells, a subpopulation of tumorigenic, aggressive, and radioresistant cells, holds therapeutic promise. However, the effects…”
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Tumor suppressor miR-218 directly targets epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer, sensitizing cells to irradiation by Wischmann, Franz-Josef, Troschel, Fabian M., Frankenberg, Maj, Kemper, Björn, Vijaya Kumar, Archana, Sicking, Mark, Ibrahim, Sherif Abdelaziz, Kiesel, Ludwig, Götte, Martin, Eich, Hans Theodor, Greve, Burkhard

“…Purpose MicroRNA-218 (miR-218) is a key regulator of numerous processes relevant to tumor progression. In the present study, we aimed to characterize the…”
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Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer by Troschel, Fabian M, Minte, Annemarie, Ismail, Yahia Mahmoud, Kamal, Amr, Abdullah, Mahmoud Salah, Ahmed, Sarah Hamdy, Deffner, Marie, Kemper, Björn, Kiesel, Ludwig, Eich, Hans Theodor, Ibrahim, Sherif Abdelaziz, Götte, Martin, Greve, Burkhard

“…The therapeutic potential of Musashi (MSI) RNA-binding proteins, important stemness-associated gene expression regulators, remains insufficiently understood in…”
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Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation by Falke, Isabel, Troschel, Fabian M, Palenta, Heike, Löblein, Maria T, Brüggemann, Kathrin, Borrmann, Katrin, Eich, Hans Theodor, Götte, Martin, Greve, Burkhard

“…Endometrial carcinoma is the most common gynecological cancer in Europe. Musashi-1 is known to be a key regulator of endometrial cancer stem cells and a…”
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Sarcopenia on preoperative chest computed tomography predicts cancer‐specific and all‐cause mortality following pneumonectomy for lung cancer: A multicenter analysis by Troschel, Fabian M., Jin, Qianna, Eichhorn, Florian, Muley, Thomas, Best, Till D., Leppelmann, Konstantin S., Yang, Chi‐Fu Jeffrey, Troschel, Amelie S., Winter, Hauke, Heußel, Claus P., Gaissert, Henning A., Fintelmann, Florian J.

“…Background Mortality risk prediction in patients undergoing pneumonectomy for non‐small cell lung cancer (NSCLC) remains imperfect. Here, we aimed to assess…”
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The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance by Sicking, Mark, Falke, Isabel, Löblein, Maria T, Eich, Hans Th, Götte, Martin, Greve, Burkhard, Troschel, Fabian M

“…Abstract RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences…”
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Feasibility of Perioperative Micro-Computed Tomography of Human Lung Cancer Specimens: A Pilot Study by Troschel, Fabian M, Gottumukkala, Ravi V, DiCorpo, Daniel, Mario, Julia, Ott, Harald C, Wright, Cameron D, Muniappan, Ashok, Lanuti, Michael, Yang, Kai, Shepard, JoAnne O, Nardi, Valentina, Michaelson, James S, Hariri, Lida P, Fintelmann, Florian J

“…Lesion localization during intraoperative frozen section of lung resection specimens can be challenging. Imaging could aid lesion localization while enabling…”
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Cervical body composition on radiotherapy planning computed tomography scans predicts overall survival in glioblastoma patients by Troschel, Fabian M., Troschel, Benjamin O., Kloss, Maren, Troschel, Amelie S., Pepper, Niklas B., Wiewrodt, Rainer G., Stummer, Walter, Wiewrodt, Dorothee, Eich, Hans Theodor

“…•Quantifying muscle and fat compartments on cervical CT scans is feasible and corresponds with established abdominal measures.•Cervical muscle measures on…”
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Inflammation, etiologies and Model for End‐stage Liver Disease score: What makes liver disease patients susceptible to developing colorectal neoplasia? by Troschel, Amelie S., Miks, Alexander, Hüsing‐Kabar, Anna, Heinzow, Hauke S., Schmidt, Hartmut H., Troschel, Fabian M., Kabar, Iyad

“…Aim Research has identified patients with chronic liver disease as a risk group for colorectal neoplasia. In this study, we aimed to identify liver disease…”
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Sarcopenia in glioblastoma: the imaging we need and what it tells us by Troschel, Fabian M., Eich, Hans Theodor

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Population-Scale CT-based Body Composition Analysis of a Large Outpatient Population Using Deep Learning to Derive Age-, Sex-, and Race-specific Reference Curves by Magudia, Kirti, Bridge, Christopher P, Bay, Camden P, Babic, Ana, Fintelmann, Florian J, Troschel, Fabian M, Miskin, Nityanand, Wrobel, William C, Brais, Lauren K, Andriole, Katherine P, Wolpin, Brian M, Rosenthal, Michael H

“…Background Although CT-based body composition (BC) metrics may inform disease risk and outcomes, obtaining these metrics has been too resource intensive for…”
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Pixel-Level Deep Segmentation: Artificial Intelligence Quantifies Muscle on Computed Tomography for Body Morphometric Analysis by Lee, Hyunkwang, Troschel, Fabian M., Tajmir, Shahein, Fuchs, Georg, Mario, Julia, Fintelmann, Florian J., Do, Synho

“…Pretreatment risk stratification is key for personalized medicine. While many physicians rely on an “eyeball test” to assess whether patients will tolerate…”
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Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer by Nipp, Ryan D., Fuchs, Georg, El‐Jawahri, Areej, Mario, Julia, Troschel, Fabian M., Greer, Joseph A., Gallagher, Emily R., Jackson, Vicki A., Kambadakone, Avinash, Hong, Theodore S., Temel, Jennifer S., Fintelmann, Florian J.

“…Background Patients with advanced cancer often experience muscle wasting (sarcopenia), yet little is known about the characteristics associated with sarcopenia…”
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High-Intensity Physical Exercise in a Glioblastoma Patient under Multimodal Treatment by TROSCHEL, FABIAN M, BRANDT, RALF, WIEWRODT, RAINER, STUMMER, WALTER, WIEWRODT, DOROTHEE

“…INTRODUCTIONGlioblastoma multiforme (GBM) carries a strongly unfavorable prognosis despite intensive multidisciplinary therapy. Physical exercise is rarely…”
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Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin’s Lymphoma Cells by TROSCHEL, FABIAN M., LINSENMAIER, MATTHIAS, BORRMANN, KATRIN, EICH, HANS THEODOR, GÖTTE, MARTIN, GREVE, BURKHARD

“…Background/aim: Heparanase (HPSE) is relevant to therapy resistance in many malignancies yet is largely unstudied in Hodgkin's lymphoma. Here, we investigated…”
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Multilevel Body Composition Analysis on Chest Computed Tomography Predicts Hospital Length of Stay and Complications After Lobectomy for Lung Cancer: A Multicenter Study by Best, Till D., Mercaldo, Sarah F., Bryan, Darren S., Marquardt, Jan Peter, Wrobel, Maria M., Bridge, Christopher P., Troschel, Fabian M., Javidan, Cylen, Chung, Jonathan H., Muniappan, Ashok, Bhalla, Sanjeev, Meyers, Bryan F., Ferguson, Mark K., Gaissert, Henning A., Fintelmann, Florian J.

“…OBJECTIVE:To investigate the impact of thoracic body composition on outcomes after lobectomy for lung cancer. SUMMARY AND BACKGROUND DATA:Preoperative…”
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Lung Recruitment in Obese Patients with Acute Respiratory Distress Syndrome by Fumagalli, Jacopo, Santiago, Roberta R S, Teggia Droghi, Maddalena, Zhang, Changsheng, Fintelmann, Florian J, Troschel, Fabian M, Morais, Caio C A, Amato, Marcelo B P, Kacmarek, Robert M, Berra, Lorenzo, Palma, Sophia, Larson, Grant M, Kaneki, Shigeru W, Fisher, Daniel, Rezoagli, Emanuele, Pirrone, Massimiliano, Marrazzo, Francesco, Zhang, Hui, Zhao, Jing

“…WHAT WE ALREADY KNOW ABOUT THIS TOPIC WHAT THIS ARTICLE TELLS US THAT IS NEW BACKGROUND:Obese patients are characterized by normal chest-wall elastance and…”
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