Search Results - "Trombitás, K"

Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness by Cazorla, O, Freiburg, A, Helmes, M, Centner, T, McNabb, M, Wu, Y, Trombitás, K, Labeit, S, Granzier, H

“…Extension of the I-band segment of titin gives rise to part of the diastolic force of cardiac muscle. Previous studies of human cardiac titin transcripts…”
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Titin–Actin Interaction in Mouse Myocardium: Passive Tension Modulation and Its Regulation by Calcium/S100A1 by Yamasaki, R., Berri, M., Wu, Y., Trombitás, K., McNabb, M., Kellermayer, M.S.Z., Witt, C., Labeit, D., Labeit, S., Greaser, M., Granzier, H.

“…Passive tension in striated muscles derives primarily from the extension of the giant protein titin. However, several studies have suggested that, in cardiac…”
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Mechanically Driven Contour-Length Adjustment in Rat Cardiac Titin's Unique N2B Sequence: Titin Is an Adjustable Spring by Helmes, M, Trombitas, K, Centner, T, Kellermayer, M, Labeit, S, Linke, W.A, Granzier, H

“…The giant elastic protein titin is largely responsible for passive forces in cardiac myocytes. A number of different titin isoforms with distinctly different…”
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Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently by Trombitás, K, Wu, Y, Labeit, D, Labeit, S, Granzier, H

“…Titin, the third myofilament type of cardiac muscle, contains a molecular spring segment that gives rise to passive forces in stretched myocardium and to…”
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Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies by Bang, Marie-Louise, Mudry, Ryan E., McElhinny, Abigail S., Trombitás, Karoly, Geach, Adam J., Yamasaki, Rob, Sorimachi, Hiroyuki, Granzier, Henk, Gregorio, Carol C., Labeit, Siegfried

“…We describe here a novel sarcomeric 145-kD protein, myopalladin, which tethers together the COOH-terminal Src homology 3 domains of nebulin and nebulette with…”
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Hierarchical Extensibility in the PEVK Domain of Skeletal-Muscle Titin by Nagy, A., Grama, L., Huber, T., Bianco, P., Trombitás, K., Granzier, H.L., Kellermayer, M.S.Z.

“…Titin is the main determinant of passive muscle force. Physiological extension of titin derives largely from its PEVK (Pro-Glu-Val-Lys) domain, which has a…”
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Molecular Basis of Passive Stress Relaxation in Human Soleus Fibers: Assessment of the Role of Immunoglobulin-Like Domain Unfolding by Trombitás, K., Wu, Y., McNabb, M., Greaser, M., Kellermayer, M.S.Z., Labeit, S., Granzier, H.

“…Titin (also known as connectin) is the main determinant of physiological levels of passive muscle force. This force is generated by the extensible I-band…”
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The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity by Gregorio, C C, Trombitás, K, Centner, T, Kolmerer, B, Stier, G, Kunke, K, Suzuki, K, Obermayr, F, Herrmann, B, Granzier, H, Sorimachi, H, Labeit, S

“…Titin is a giant elastic protein in vertebrate striated muscles with an unprecedented molecular mass of 3-4 megadaltons. Single molecules of titin extend from…”
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Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension by Trombitás, K, Granzier, H

“…The I band of cardiac sarcomeres contains both actin and titin/connectin filaments. Earlier work has suggested that titin binds to actin in situ. This…”
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Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction by Granzier, H., Kellermayer, M., Helmes, M., Trombitás, K.

“…Titin (also known as connectin) is a giant filamentous protein whose elastic properties greatly contribute to the passive force in muscle. In the sarcomere,…”
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Titin Develops Restoring Force in Rat Cardiac Myocytes by Helmes, Michiel, Trombitas, Karoly, Granzier, Henk

“…When relaxed after contraction, isolated cardiac myocytes quickly relengthen back to their slack length. The molecular basis of the force that underlies…”
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Titin Extensibility in situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments by Trombitás, Karoly, Greaser, Marion, Labeit, Siegfried, Jin, Jian-Ping, Kellermayer, Miklós, Helmes, Michiel, Granzier, Henk

“…Titin (also known as connectin) is a giant protein that spans half of the striated muscle sarcomere. In the I-band titin extends as the sarcomere is stretched,…”
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Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics by Granzier, H., Helmes, M., Trombitás, K.

“…Titin (also known as connectin) is a muscle-specific giant protein found inside the sarcomere, spanning from the Z-line to the M-line. The I-band segment of…”
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PEVK Extension of Human Soleus Muscle Titin Revealed by Immunolabeling with the Anti-titin Antibody 9D10 by Trombitás, K., Greaser, M., French, G., Granzier, H.

“…Titin is a giant protein that spans half of the striated muscle sarcomere. The I-band portion of titin extends as the sarcomere is stretched, developing what…”
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Molecular Dissection of N2B Cardiac Titin’s Extensibility by Trombitás, Karoly, Freiburg, Alexandra, Centner, Thomas, Labeit, Siegfried, Granzier, Henk

“…Titin is a giant filamentous polypeptide of multidomain construction spanning between the Z- and M-lines of the cardiac muscle sarcomere. Extension of the…”
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Extensibility of Isoforms of Cardiac Titin: Variation in Contour Length of Molecular Subsegments Provides a Basis for Cellular Passive Stiffness Diversity by Trombitás, Karoly, Redkar, Alka, Centner, Thomas, Wu, Yiming, Labeit, Siegfried, Granzier, Henk

“…Titin is a giant polypeptide that spans between the Z- and M-lines of the cardiac muscle sarcomere and that develops force when extended. This force arises…”
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The Mechanically Active Domain of Titin in Cardiac Muscle by Trombitas, Karoly, Jin, Jian-Ping, Granzier, Henk

“…One of the main contributors to passive tension of the myocardium is titin. However, it is not exactly known what portions of this approximate equal 1 micro…”
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Cross-bridge interaction with oppositely polarized actin filaments in double-overlap zones of insect flight muscle by Trombitas, K, Tigyi-Sebes, A

“…An unresolved problem in understanding muscular contraction is why the internal resistance to sarcomere shortening increases progressively during contraction…”
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Connecting filaments: a historical prospective by Trombitás, K

“…This short review covers the development of the extensible filament research from the very beginning until the most recent results. This work emphasizes the…”
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Effect of tension on the rigor cross-bridge angle by Trombitás, K, Baatsen, P H, Pollack, G H

“…The effect of resting tension and external force on the rigor crossbridge angle was investigated in insect flight muscle (Honeybee, Apis mellifera). In the…”
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