Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson’s disease

Highlights ► We show important changes in the neurochemical parameters induced by exercise. ► We demonstrated that exercise exerts a protective effect against PD-induced oxidative stress. ► We showed that physical exercise modulates TH, α-synuclein, BNDF and SERCA II in the striatum. ► The effect of...

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Bibliographic Details
Published in:Neuroscience Vol. 227; pp. 305 - 312
Main Authors: Tuon, T, Valvassori, S.S, LOPES-BORGES, J, Luciano, T, Trom, C.B, Silva, L.A, Quevedo, J, Souza, C.T, Lira, F.S, Pinho, R.A
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Ltd 27-12-2012
Elsevier
Subjects:
UPD
TPD
GPX
SOD
USO
TSO
PD
TH
CAT
Rat
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Summary:Highlights ► We show important changes in the neurochemical parameters induced by exercise. ► We demonstrated that exercise exerts a protective effect against PD-induced oxidative stress. ► We showed that physical exercise modulates TH, α-synuclein, BNDF and SERCA II in the striatum. ► The effect of exercise is the ability to modulate the redox state and preserve the content of proteins.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.09.063