Search Results - "Trogden, Kathryn P"

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots by Trogden, Kathryn P, Lee, Justin, Bracey, Kai M, Ho, Kung-Hsien, McKinney, Hudson, Zhu, Xiaodong, Arpag, Goker, Folland, Thomas G, Osipovich, Anna B, Magnuson, Mark A, Zanic, Marija, Gu, Guoqiang, Holmes, William R, Kaverina, Irina

“…Heterogeneity of glucose-stimulated insulin secretion (GSIS) in pancreatic islets is physiologically important but poorly understood. Here, we utilize mouse…”
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TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics by Trogden, Kathryn P, Rogers, Stephen L

“…Microtubules are regulated by a diverse set of proteins that localize to microtubule plus ends (+TIPs) where they regulate dynamic instability and mediate…”
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An image‐based small‐molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells by Trogden, Kathryn P., Battaglia, Rachel A., Kabiraj, Parijat, Madden, Victoria J., Herrmann, Harald, Snider, Natasha T.

“…Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial‐mesenchymal transition…”
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Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells by Trogden, Kathryn P., Zhu, Xiaodong, Lee, Justin S., Wright, Christopher V.E., Gu, Guoqiang, Kaverina, Irina

“…The microtubule (MT) network is an essential regulator of insulin secretion from pancreatic β cells, which is central to blood-sugar homeostasis. We find that…”
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Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation by Sullivan-Brown, Jessica L, Tandon, Panna, Bird, Kim E, Dickinson, Daniel J, Tintori, Sophia C, Heppert, Jennifer K, Meserve, Joy H, Trogden, Kathryn P, Orlowski, Sara K, Conlon, Frank L, Goldstein, Bob

“…Neural tube defects including spina bifida are common and severe congenital disorders. In mice, mutations in more than 200 genes can result in neural tube…”
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TOG Proteins Are Spatially Regulated by Rac-GSK3[beta] to Control Interphase Microtubule Dynamics by Trogden, Kathryn P, Rogers, Stephen L

“…Microtubules are regulated by a diverse set of proteins that localize to microtubule plus ends (+TIPs) where they regulate dynamic instability and mediate…”
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Targeting of a Novel Phosphorylation Site Prevents Disease Mutation‐associated Aggregation of Glial Fibrillary Acidic Protein (GFAP) by Kabiraj, Parijat, Trogden, Kathryn P, Snider, Natasha T

“…Abstract only…”
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The intermediate filament cytoskeleton is a target of statins and statin‐induced cancer cell death by Trogden, Kathryn P, Kabiraj, Parijat, Snider, Natasha T

“…Abstract only…”
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Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation by Sullivan-Brown, Jessica L, Tandon, Panna, Bird, Kim E, Dickinson, Daniel J, Tintori, Sophia C, Heppert, Jennifer K, Meserve, Joy H, Trogden, Kathryn P, Orlowski, Sara K, Conlon, Frank L, Goldstein, Bob

“…Neural tube defects including spina bifida are common and severe congenital disorders. In mice, mutations in more than 200 genes can result in neural tube…”
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TOG proteins are spatially regulated by Rac-GSK3β to control interphase microtubule dynamics by Trogden, Kathryn P

“…Within a cell, the ends of individual microtubules switch between three different phases: growth, shrinkage and pause without affecting the total mass of…”
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