Search Results - "Troconiz, I. F."

Population Pharmacokinetics of Ganciclovir after Intravenous Ganciclovir and Oral Valganciclovir Administration in Solid Organ Transplant Patients Infected with Cytomegalovirus by CALDES, A, COLOM, H, ARMENDARIZ, Y, GARRIDO, M. J, TROCONIZ, I. F, GIL-VERNET, S, LLOBERAS, N, POU, L, PERAIRE, C, GRINYO, J. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacokinetic–pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase‐2, in rats by Vásquez‐Bahena, DA, Salazar‐Morales, UE, Ortiz, MI, Castañeda‐Hernández, G, Trocóniz, IF

“…Background and purpose:  This study establishes a pharmacokinetic/pharmacodynamic (PK/PD) model to describe the time course and in vivo mechanisms of action of…”
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Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology: Challenges and Opportunities by Venkatakrishnan, K, Friberg, LE, Ouellet, D, Mettetal, JT, Stein, A, Trocóniz, IF, Bruno, R, Mehrotra, N, Gobburu, J, Mould, DR

“…Despite advances in biomedical research that have deepened our understanding of cancer hallmarks, resulting in the discovery and development of targeted…”
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A pharmacokinetic-pharmacodynamic assessment of oral antibiotics for pyelonephritis by Cattrall, J. W. S., Asín-Prieto, E., Freeman, J., Trocóniz, I. F., Kirby, A.

“…Antibiotic resistance to oral antibiotics recommended for pyelonephritis is increasing. The objective was to determine if there is a pharmacological basis to…”
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Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis by Asín-Prieto, Eduardo, Rodríguez-Gascón, Alicia, Trocóniz, Iñaki F, Soraluce, Amaia, Maynar, Javier, Sánchez-Izquierdo, José Ángel, Isla, Arantxazu

“…To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill patients undergoing continuous renal replacement therapy (CRRT) and to assess the…”
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Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2 by Hannam, Jacqueline A, Borrat, Xavier, Trocóniz, Iñaki F, Valencia, José F, Jensen, Erik W, Pedroso, Angela, Muñoz, Jenifer, Castellví-Bel, Sergi, Castells, Antoni, Gambús, Pedro L

“…Respiratory depression is a common adverse effect of propofol and remifentanil. We aimed to develop a model for respiratory depressant effects of propofol with…”
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Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits by Reynaldo-Fernández, G., Solozábal, J., Amaro, D., Fernández-Sánchez, E.M., Rodríguez-Vera, L., Bermejo, M., Mangas-Sanjuan, V., Troconiz, I.F.

“…Marketed formulations of erythropoietin (EPO) ior®EPOCIM, MIRCERA® and two newly developed pegylated-EPO analogues (PEG-EPO 32 and 40 kDa) formulations were…”
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Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome by Gambús, P.L, Trocóniz, I.F, Feng, X, Gimenez-Milá, M, Mellado, R, Degos, V, Vacas, S, Maze, M

“…Highlights • Surgical trauma generates a postoperative learning deficit. • Severity of memory decline at 1 week after surgery presages long-lasting…”
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Modeling the Effect of Propofol and Remifentanil Combinations for Sedation-Analgesia in Endoscopic Procedures Using an Adaptive Neuro Fuzzy Inference System (ANFIS) by Gambús, P. L., Jensen, E. W., Jospin, M., Borrat, X., Pallí, G. Martínez, Fernández-Candil, J., Valencia, J. F., Barba, X., Caminal, P., Trocóniz, I. F.

“…The increasing demand for anesthetic procedures in the gastrointestinal endoscopy area has not been followed by a similar increase in the methods to provide…”
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Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain by Taneja, A., Troconiz, I. F., Danhof, M., Della Pasqua, O.

“…Purpose The formalin-induced rat model of nociception involves moderate continuous pain. Formalin-induced pain results in a typical repetitive flinching…”
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Prediction of Neutropenia-Related Effects of a New Combination Therapy With the Anticancer Drugs BI 2536 (a Plk1 Inhibitor) and Pemetrexed by Soto, E, Staab, A, Freiwald, M, Munzert, G, Fritsch, H, Döge, C, Trocóniz, I F

“…This study investigated the feasibility of predicting the neutropenia‐related effects of a therapy that combines the investigational drug BI 2536 (inhibitor of…”
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Commentary on Pharmacometrics for Immunotherapy by Garrido, MJ, Berraondo, P, Trocóniz, IF

“…This commentary provides an overview of recent examples of pharmacometrics applied during the clinical development of two antagonists of the programmed death‐1…”
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A different kinetic profile of ochratoxin A in mature male rats by Vettorazzi, A., Gonzalez-Peñas, E., Trocóniz, I.F., Arbillaga, L., Corcuera, L.A., Gil, A.G., López de Cerain, A.

“…Ochratoxin A (OTA) is a mycotoxin that causes renal tumors in rodents, particularly in male rats. The present work explored the impact of gender and age on OTA…”
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Enantiomeric separation of tramadol and its active metabolite in human plasma by chiral high-performance liquid chromatography: Application to pharmacokinetic studies by Campanero, M.A., Calahorra, B., Valle, M., Troconiz, I.F., Honorato, J.

“…A sensitive and stereoselective high‐performance liquid chromatographic assay for the quantitative determination of the analgesic tramadol and…”
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Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats by Vettorazzi, A., Trocóniz, I.F., Gonzalez-Peñas, E., Corcuera, L.A., Arbillaga, L., Gil, A.G., Nagy, J.M., Mantle, P.G., López de Cerain, A.

“…Ochratoxin A (OTA) is a mycotoxin that causes renal tumors in rats, particularly in males. In previous kinetic studies performed in fed conditions ( Vettorazzi…”
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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development by Swat, MJ, Moodie, S, Wimalaratne, SM, Kristensen, NR, Lavielle, M, Mari, A, Magni, P, Smith, MK, Bizzotto, R, Pasotti, L, Mezzalana, E, Comets, E, Sarr, C, Terranova, N, Blaudez, E, Chan, P, Chard, J, Chatel, K, Chenel, M, Edwards, D, Franklin, C, Giorgino, T, Glont, M, Girard, P, Grenon, P, Harling, K, Hooker, AC, Kaye, R, Keizer, R, Kloft, C, Kok, JN, Kokash, N, Laibe, C, Laveille, C, Lestini, G, Mentré, F, Munafo, A, Nordgren, R, Nyberg, HB, Parra‐Guillen, ZP, Plan, E, Ribba, B, Smith, G, Trocóniz, IF, Yvon, F, Milligan, PA, Harnisch, L, Karlsson, M, Hermjakob, H, Le Novère, N

“…The lack of a common exchange format for mathematical models in pharmacometrics has been a long‐standing problem. Such a format has the potential to increase…”
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Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil by Schwartz, J B, Troconiz, I F, Verotta, D, Liu, S, Capili, H

“…Pharmacokinetics and pharmacodynamics were studied after separate single 15-min infusions of each of verapamil's enantiomers (d, 10-11 mg/kg; l, 0.10-0.11…”
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CORRIGENDUM: Commentary on Pharmacometrics for Immunotherapy by Garrido, MJ, Berraondo, P, Trocóniz, IF

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Semiparametric models for antagonistic drug interactions by Troconiz, I F, Sheiner, L B, Verotta, D

“…A new class of models to describe antagonistic drug interactions are presented. They are semiparametric in that they use nonparametric functions (splines) but…”
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Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility by de Smidt, P.Chris, Campanero, Miguel A, Trocóniz, Iñaki F

“…While the inclusion of highly lipophilic compounds in self-emulsifying drug delivery systems (SEDDS) is often reported to result in strongly enhanced oral…”
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