Search Results - "Troche, Harrison R."

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    Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction

    Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction by Ita, Meagan E., Ghimire, Prabesh, Welch, Rachel L., Troche, Harrison R., Winkelstein, Beth A.

    Published in Scientific reports (15-12-2020)
    “…Degeneration is a hallmark of painful joint disease and is mediated by many proteases that degrade joint tissues, including collagenases. We hypothesized that…”
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    Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading

    Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading by Ita, Meagan E., Singh, Sagar, Troche, Harrison R., Welch, Rachel L., Winkelstein, Beth A.

    “…Chronic joint pain is a major healthcare challenge with a staggering socioeconomic burden. Pain from synovial joints is mediated by the innervated collagenous…”
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