Search Results - "Trivedi, Darshan V"

To lie or not to lie: Super-relaxing with myosins by Nag, Suman, Trivedi, Darshan V

“…Since the discovery of muscle in the 19th century, myosins as molecular motors have been extensively studied. However, in the last decade, a new functional…”
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The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations by Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A

“…A working model for β-cardiac myosin in the sequestered state and binding assays reveal interactions between the myosin head and tail that are disrupted by…”
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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity by Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.

“…Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found…”
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Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light by Trivedi, Darshan V., Adhikari, Arjun S., Sarkar, Saswata S., Ruppel, Kathleen M., Spudich, James A.

“…The sarcomere is an exquisitely designed apparatus that is capable of generating force, which in the case of the heart results in the pumping of blood…”
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Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V by Trivedi, Darshan V., Muretta, Joseph M., Swenson, Anja M., Davis, Jonathon P., Thomas, David D., Yengo, Christopher M.

“…Myosins use a conserved structural mechanism to convert the energy from ATP hydrolysis into a large swing of the force-generating lever arm. The precise timing…”
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Switch II Mutants Reveal Coupling between the Nucleotide- and Actin-Binding Regions in Myosin V by Trivedi, Darshan V., David, Charles, Jacobs, Donald J., Yengo, Christopher M.

“…Conserved active-site elements in myosins and other P-loop NTPases play critical roles in nucleotide binding and hydrolysis; however, the mechanisms of…”
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Magnesium Modulates Actin Binding and ADP Release in Myosin Motors by Swenson, Anja M., Trivedi, Darshan V., Rauscher, Anna A., Wang, Yuan, Takagi, Yasuharu, Palmer, Bradley M., Málnási-Csizmadia, András, Debold, Edward P., Yengo, Christopher M.

“…We examined the magnesium dependence of five class II myosins, including fast skeletal muscle myosin, smooth muscle myosin, β-cardiac myosin (CMIIB),…”
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Magnesium Impacts Myosin V Motor Activity by Altering Key Conformational Changes in the Mechanochemical Cycle by Trivedi, Darshan V, Muretta, Joseph M, Swenson, Anja M, Thomas, David D, Yengo, Christopher M

“…We investigated how magnesium (Mg) impacts key conformational changes during the ADP binding/release steps in myosin V and how these alterations impact the…”
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Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers by Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.

“…Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However,…”
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The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches by Trivedi, Darshan V, Nag, Suman, Spudich, Annamma, Ruppel, Kathleen M, Spudich, James A

“…Myosins are among the most fascinating enzymes in biology. As extremely allosteric chemomechanical molecular machines, myosins are involved in myriad pivotal…”
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SETD3 is an actin histidine methyltransferase that prevents primary dystocia by Wilkinson, Alex W., Diep, Jonathan, Dai, Shaobo, Liu, Shuo, Ooi, Yaw Shin, Song, Dan, Li, Tie-Mei, Horton, John R., Zhang, Xing, Liu, Chao, Trivedi, Darshan V., Ruppel, Katherine M., Vilches-Moure, José G., Casey, Kerriann M., Mak, Justin, Cowan, Tina, Elias, Joshua E., Nagamine, Claude M., Spudich, James A., Cheng, Xiaodong, Carette, Jan E., Gozani, Or

“…For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur 1 . Despite the pervasiveness of His73 methylation, which we…”
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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness by Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András

“…Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population. Current medications are of limited…”
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Converter domain mutations in myosin alter structural kinetics and motor function by Gunther, Laura K., Rohde, John A., Tang, Wanjian, Walton, Shane D., Unrath, William C., Trivedi, Darshan V., Muretta, Joseph M., Thomas, David D., Yengo, Christopher M.

“…Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and…”
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The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin by Sarkar, Saswata S, Trivedi, Darshan V, Morck, Makenna M, Adhikari, Arjun S, Pasha, Shaik N, Ruppel, Kathleen M, Spudich, James A

“…Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early…”
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Uncovering the Molecular and Structural Basis of Hypertrophic Cardiomyopathy-Causing Mutations in Myosin and Myosin Binding Protein-C by Nandwani, Neha, Trivedi, Darshan V., Sarkar, Saswata S., Morck, Makenna, Ruppel, Kathleen, Spudich, James A.

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First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2 by Gyimesi, Mate, Horvath, Adam I., Turos, Demeter, Kumar Suthar, Sharad, Penzes, Mate, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen, Trivedi, Darshan V., Spudich, James A., Rauscher, Anna Á., Kovacs, Mihaly, Komoly, Samuel, Houdusse, Anne M., Malnasi-Csizmadia, Andras

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Hypertrophic Cardiomyopathy Mutations Disrupt Human Beta Cardiac Myosin Intramolecular Interactions Leading to Increased Myosin Activity by Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Ruppel, Kathleen M., James, Spudich A.

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Converter Mutation Disrupts Lever arm Rotation in Myosin V by Swenson, Anja M., Trivedi, Darshan V., Yengo, Christopher M.

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A Molecular Approach to Understand the Super-Relaxed State of Myosin Observed in Cardiac Muscle by Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Ruppel, Kathleen M., Spudich, James A.

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Impact of Hypertrophic Cardiomyopathy Mutations and the Role of Myosin Binding Protein-C on the Sequestered State of Myosin by Trivedi, Darshan V., Sarkar, Saswata S., Morck, Makenna M., Adhikari, Arjun A., Ruppel, Kathleen M., Spudich, James A.

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