Search Results - "Tritschler, Laurent"

Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression by Mendez-David, Indira, Tritschler, Laurent, Ali, Zeina El, Damiens, Marie-Hélène, Pallardy, Marc, David, Denis J., Kerdine-Römer, Saadia, Gardier, Alain M.

“…•Nrf2 signaling is affected in a mouse model of anxiety/depression (the CORT model).•Chronic fluoxetine treatment restored these levels of expression.•Nrf2−/−…”
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Rapid analysis of glutamate, glutamine and GABA in mice frontal cortex microdialysis samples using HPLC coupled to electrospray tandem mass spectrometry by Defaix, Celine, Solgadi, Audrey, Pham, Thu Ha, Gardier, Alain M., Chaminade, Pierre, Tritschler, Laurent

“…•A simple LC–MS/MS method to quantify glutamate, glutamine and GABA in mice mPFC dialysates.•Precision and accuracy of the methods.•Validated method by…”
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A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors by Nautiyal, Katherine M, Tritschler, Laurent, Ahmari, Susanne E, David, Denis J, Gardier, Alain M, Hen, René

“…The effects of serotonin (5-HT) on anxiety and depression are mediated by a number of 5-HT receptors, including autoreceptors that act to inhibit 5-HT release…”
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Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity by Nautiyal, Katherine M, Tanaka, Kenji F, Barr, Mary M, Tritschler, Laurent, Le Dantec, Yannick, David, Denis J, Gardier, Alain M, Blanco, Carlos, Hen, René, Ahmari, Susanne E

“…Impulsive and aggressive behaviors are both modulated by serotonergic signaling, specifically through the serotonin 1B receptor (5-HT1BR). 5-HT1BR knockout…”
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Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review by Nguyen, Thi Mai Loan, Jollant, Fabrice, Tritschler, Laurent, Colle, Romain, Corruble, Emmanuelle, Gardier, Alain M

“…Around 700,000 people die from suicide each year in the world. Approximately 90% of suicides have a history of mental illness, and more than two-thirds occur…”
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Learning and memory impairments in a neuroendocrine mouse model of anxiety/depression by Darcet, Flavie, Mendez-David, Indira, Tritschler, Laurent, Gardier, Alain M, Guilloux, Jean-Philippe, David, Denis J

“…Cognitive disturbances are often reported as serious incapacitating symptoms by patients suffering from major depressive disorders (MDDs). Such deficits have…”
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S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms by Mendez-David, Indira, Guilloux, Jean-Philippe, Papp, Mariusz, Tritschler, Laurent, Mocaer, Elisabeth, Gardier, Alain M, Bretin, Sylvie, David, Denis J

“…Glutamatergic dysfunctions are observed in the pathophysiology of depression. The glutamatergic synapse as well as the AMPA receptor's (AMPAR) activation may…”
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The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors by SEMINATORE, Christine, POLENTES, Jerome, LHUILLIER, Mickael, BUGI, Aurore, AUBRY, Laetitia, JENDELOVA, Pavla, SYKOVA, Eva, PERRIER, Anselme L, FINSEN, Bente, ONTENIENTE, Brigitte, ELLMAN, Ditte, KOZUBENKO, Nataliya, ITIER, Valerie, TINE, Samir, TRITSCHLER, Laurent, BRENOT, Marion, GUIDOU, Emmanuelle, BLONDEAU, Johanna

“…Risk of tumorigenesis is a major obstacle to human embryonic and induced pluripotent stem cell therapy. Likely linked to the stage of differentiation of the…”
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Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens by Tritschler, Laurent, Kheirbek, Mazen A., Dantec, Yannick Le, Mendez-David, Indira, Guilloux, Jean-Philippe, Faye, Charlène, Doan, Julie, Pham, Thu Ha, Hen, René, David, Denis J., Gardier, Alain M.

“…The dentate gyrus (DG) has distinct roles along its dorso-ventral axis. In the mouse, we recently demonstrated that dorsal DG (dDG) stimulation enhances…”
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Pro-inflammatory mediators and apoptosis correlate to rt-PA response in a novel mouse model of thromboembolic stroke by Ansar, Saema, Chatzikonstantinou, Eva, Thiagarajah, Rushani, Tritschler, Laurent, Fatar, Marc, Hennerici, Michael G, Meairs, Stephen

“…A recent study suggests that patients with persistent occlusion of the middle cerebral artery (MCA) following treatment with recombinant tissue plasminogen…”
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Role of adult-born granule cells in the hippocampal functions: Focus on the GluN2B-containing NMDA receptors by Doan, Julie, Gardier, Alain M., Tritschler, Laurent

“…Adult-born granule cells constitute a small subpopulation of the dentate gyrus (DG) in the hippocampus. However, they greatly influence several…”
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Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine by Pham, Thu Ha, Defaix, Céline, Nguyen, Thi Mai Loan, Mendez-David, Indira, Tritschler, Laurent, David, Denis J., Gardier, Alain M.

“…At sub-anaesthetic doses, ketamine, a non competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant…”
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Cortical and raphe GABA A , AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine by Pham, Thu Ha, Defaix, Céline, Nguyen, Thi Mai Loan, Mendez-David, Indira, Tritschler, Laurent, David, Denis J, Gardier, Alain M

“…At sub-anaesthetic doses, ketamine, a non competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant…”
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Adult Hippocampal Neurogenesis is Required for Vortioxetine-Induced Prevention of Anxiety/Depression Relapse Phenotype by David, Indira, Shah, Abhishek, Guilloux, Jean-Philippe, Colle, Romain, Tritschler, Laurent, Defaix, Céline, Hen, Rene, Denny, Christine, Gardier, Alain, Corruble, Emmanuelle, David, Denis

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Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity by Nguyen, Thi Mai Loan, Defaix, Céline, Mendez-David, Indira, Tritschler, Laurent, Etting, Isabelle, Alvarez, Jean-Claude, Choucha, Walid, Colle, Romain, Corruble, Emmanuelle, David, Denis J., Gardier, Alain M.

“…In 2019, an intranasal (IN) spray of esketamine SPRAVATO® was approved as a fast-acting antidepressant by drug Agencies US FDA and European EMA. At…”
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Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain by Lehmann, Olivia, Jeltsch, Hélène, Lazarus, Christine, Tritschler, Laurent, Bertrand, Fabrice, Cassel, Jean-Christophe

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Ketamine and suicidal behavior: Contribution of animal models of aggression-impulsivity to understanding its mechanism of action by Nguyen, Thi Mai Loan, Jollant, Fabrice, Tritschler, Laurent, Colle, Romain, Corruble, Emmanuelle, Gardier, Alain M

“…More than two-thirds of suicides occur during a major depressive episode. Acting out prevention measures and therapeutic options to manage the suicidal crisis…”
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A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin by Mendez‐David, Indira, David, Denis Joseph, Deloménie, Claudine, Tritschler, Laurent, Beaulieu, Jean‐Martin, Colle, Romain, Corruble, Emmanuelle, Gardier, Alain Michel, Hen, René

“…We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN). After confirming…”
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Serotonin 3 Receptor Blockade is Involved in Vortioxetine -Induced Prevention of Anxiety/Depression Relapse Phenotype by Mendez-David, Indira, Guilloux, Jean-Philippe, Shah, Abhishek, Tritschler, Laurent, Defaix, Céline, Fossati, Philippe, Colle, Romain, Hen, René, Denny, Christine, Gardier, Alain, Corruble, Emmanuelle, David, Denis

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Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging by Wetterling, Friedrich, Chatzikonstantinou, Eva, Tritschler, Laurent, Meairs, Stephen, Fatar, Marc, Schad, Lothar R, Ansar, Saema

“…Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0-24 h) ischemic stroke tissue. However,…”
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