Search Results - "Tripp, Catherine S."

Epidermal COX-2 Induction Following Ultraviolet Irradiation: Suggested Mechanism for the Role of COX-2 Inhibition in Photoprotection by Tripp, Catherine S., Blomme, Eric A.G., Chinn, Kevin S., Hardy, Medora M., LaCelle, Peter, Pentland, Alice P.

“…The cyclooxygenase isoforms, COX-1 and COX-2, are involved in the biosynthesis of prostaglandin E2, a major prostaglandin involved in epidermal homeostasis and…”
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Regulation and Phenotype of an Innate Th1 Cell: Role of Cytokines and the p38 Kinase Pathway by Yu, Jeffrey J, Tripp, Catherine S, Russell, John H

“…We have explored the phenotype and regulation of Th1 cell activation by the cytokines IL-12 and IL-18. We demonstrate that these two cytokines selectively…”
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RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study by Tripp, Catherine S., Cuff, Carolyn, Campbell, Andrew L., Hendrickson, Barbara A., Voss, Jeff, Melim, Terry, Wu, Chengbin, Cherniack, Andrew D., Kim, Kenneth

“…Introduction A unique anti-interleukin (IL)-13 monoclonal antibody, RPC4046, was generated on the basis of differential IL-13 receptor (R) blockade as assessed…”
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A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts by Kishore, Nandini, Sommers, Cindy, Mathialagan, Sumathy, Guzova, Julia, Yao, Min, Hauser, Scott, Huynh, Khai, Bonar, Sheri, Mielke, Cindy, Albee, Lee, Weier, Richard, Graneto, Matthew, Hanau, Cathleen, Perry, Thao, Tripp, Catherine S.

“…NF-κB-induced gene expression contributes significantly to the pathogenesis of inflammatory diseases such as arthritis. IκB kinase (IKK) is the converging…”
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Selective cyclooxygenase-2 inhibition does not alter keratinocyte wound responses in the mouse epidermis after abrasion by Hardy, Medora M, Blomme, Eric A G, Lisowski, Andrew, Chinn, Kevin S, Jones, Amy, Harmon, Janet M, Opsahl, Alan, Ornberg, Richard L, Tripp, Catherine S

“…The cyclooxygenase isoforms, COX-1 and COX-2, are the rate limiting enzymes in the biosynthesis of prostaglandin E(2), a major prostaglandin involved in…”
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IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2 by Kishore, Nandini, Huynh, Q Khai, Mathialagan, Sumathy, Hall, Troii, Rouw, Sharon, Creely, David, Lange, Gary, Caroll, James, Reitz, Beverley, Donnelly, Ann, Boddupalli, Hymavathi, Combs, Rodney G, Kretzmer, Kuniko, Tripp, Catherine S

“…NF-kappaB is sequestered in the cytoplasm by the inhibitory IkappaB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IkappaBs…”
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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages by CHYI-SONG HSIEH, MACATONIA, S. E, TRIPP, C. S, WOLF, S. F, O'GARRA, A, MURPHY, K. M

“…Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. With the use of naïve,…”
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Cyclooxygenase 2‐dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants by Hardy, Medora M., Seibert, Karen, Manning, Pamela T., Currie, Mark G., Woerner, B. Mark, Edwards, Dorothy, Koki, Alane, Tripp, Catherine S.

“…Objective To examine cyclooxygenase‐2 (COX‐2) enzyme expression, its regulation by interleukin‐1β (IL‐1β), and the role of prostaglandin E2 (PGE2) in…”
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Pillars article: development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. 1993. Science 260(5107): 547-549 by Hsieh, Chyi-Song, Macatonia, Steven E, Tripp, Catherine S, Wolf, Stanley F, O'Garra, Anne, Murphy, Kenneth M

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Aminopyridinecarboxamide-based inhibitors: Structure–activity relationship by Bonafoux, Dominique F., Bonar, Sheri L., Clare, Michael, Donnelly, Ann M., Glaenzer, Jeanette L., Guzova, Julia A., Huang, He, Kishore, Nandidni N., Koszyk, Francis J., Lennon, Patrick J., Libby, Adam, Mathialagan, Sumathy, Oburn, David S., Rouw, Sharon A, Sommers, Cynthia D., Tripp, Catherine S., Vanella, Lori J., Weier, Richard, Wolfson, Serge G., Huang, Horng-Chih

“…Aminopyridinecarboxamide-based iKK-2 inhibitors were synthesized and tested leading to the 2-amino-5-chloropyridine-4-carboxamides as potent inhibitors with…”
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IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2 by Kishore, Nandini, Huynh, Q. Khai, Mathialagan, Sumathy, Hall, Troii, Rouw, Sharon, Creely, David, Lange, Gary, Caroll, James, Reitz, Beverley, Donnelly, Ann, Boddupalli, Hymavathi, Combs, Rodney G., Kretzmer, Kuniko, Tripp, Catherine S.

“…NF-κB is sequestered in the cytoplasm by the inhibitory IκB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IκBs leading to…”
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Characterization of the Recombinant IKK1/IKK2 Heterodimer by Huynh, Q. Khai, Boddupalli, Hymavathi, Rouw, Sharon A., Koboldt, Carol M., Hall, Troii, Sommers, Cindy, Hauser, Scott D., Pierce, Jennifer L., Combs, Rodney G., Reitz, Beverly A., Diaz-Collier, Judy A., Weinberg, Robin A., Hood, Becky L., Kilpatrick, Bryan F., Tripp, Catherine S.

“…Nuclear factor kappa B (NF-κB) is a ubiquitous, inducible transcription factor that regulates the initiation and progression of immune and inflammatory stress…”
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Interleukin 12 and Tumor Necrosis Factor α are Costimulators of Interferon γ Production by Natural Killer Cells in Severe Combined Immunodeficiency Mice with Listeriosis, and Interleukin 10 is a Physiologic Antagonist by Tripp, Catherine S., Wolf, Stanley F., Unanue, Emil R.

“…Listeriosis in mice with the severe combined immunodeficiency (SCID) mutation is an established model in vivo and in vitro of interferon γ (IFN-γ)-dependent…”
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Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma by Tripp, CS, Gately, MK, Hakimi, J, Ling, P, Unanue, ER

“…Interleukin-12 (IL-12) is necessary for the production of IFN-gamma by NK cells during the generation of innate immunity and by T cells for the development of…”
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Kinetic Mechanisms of IκB-related Kinases (IKK) Inducible IKK and TBK-1 Differ from IKK-1/IKK-2 Heterodimer by Huynh, Q. Khai, Kishore, Nandini, Mathialagan, Sumathy, Donnelly, Ann M., Tripp, Catherine S.

“…Nuclear factor-κB activation depends on phosphorylation and degradation of its inhibitor protein, IκB. The phosphorylation of IκBα on Ser32 and Ser36 is…”
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Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity by Huynh, Q K, Boddupalli, H, Rouw, S A, Koboldt, C M, Hall, T, Sommers, C, Hauser, S D, Pierce, J L, Combs, R G, Reitz, B A, Diaz-Collier, J A, Weinberg, R A, Hood, B L, Kilpatrick, B F, Tripp, C S

“…Nuclear factor kappa B (NF-kappaB) is a ubiquitous, inducible transcription factor that regulates the initiation and progression of immune and inflammatory…”
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Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12 by Tripp, CS, Kanagawa, O, Unanue, ER

“…During a secondary immune response to Listeria monocytogenes (LM), the production of IFN-gamma was still required for resistance, but it was considerably less…”
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Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer by Huynh, Q Khai, Kishore, Nandini, Mathialagan, Sumathy, Donnelly, Ann M, Tripp, Catherine S

“…Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkappaB. The phosphorylation of IkappaBalpha on Ser(32)…”
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Kinetic Mechanisms of IκB-related Kinases (IKK) Inducible IKK and TBK-1 Differ from IKK-1/IKK-2 Heterodimer by Q. Khai Huynh, Nandini Kishore, Sumathy Mathialagan, Ann M. Donnelly, Catherine S. Tripp

“…Nuclear factor-κB activation depends on phosphorylation and degradation of its inhibitor protein, IκB. The phosphorylation of IκBα on Ser 32 and Ser 36 is…”
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Endogenous IL-1 is required for neutrophil recruitment and macrophage activation during murine listeriosis by Rogers, HW, Tripp, CS, Schreiber, RD, Unanue, ER

“…By using a mixture of neutralizing mAbs to IL-1 alpha, IL-1 beta, and to the type I IL-1R, we previously documented a regulatory role for IL-1 in the…”
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