Search Results - "Triplett, William T"

Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study by Forbes, Sean C, Willcocks, Rebecca J, Triplett, William T, Rooney, William D, Lott, Donovan J, Wang, Dah-Jyuu, Pollaro, Jim, Senesac, Claudia R, Daniels, Michael J, Finkel, Richard S, Russman, Barry S, Byrne, Barry J, Finanger, Erika L, Tennekoon, Gihan I, Walter, Glenn A, Sweeney, H Lee, Vandenborne, Krista

“…Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that results in functional deficits. However, these functional declines are often not able…”
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Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials by Kim, Sarah, Willcocks, Rebecca J, Daniels, Michael J, Morales, Juan Francisco, Yoon, Deok Yong, Triplett, William T, Barnard, Alison M, Conrado, Daniela J, Aggarwal, Varun, Belfiore-Oshan, Ramona, Martinez, Terina N, Walter, Glenn A, Rooney, William D, Vandenborne, Krista

“…Although regulatory agencies encourage inclusion of imaging biomarkers in clinical trials for Duchenne muscular dystrophy (DMD), industry receives minimal…”
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Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy by Willcocks, Rebecca J., Barnard, Alison M., Daniels, Michael J., Forbes, Sean C., Triplett, William T., Brandsema, John F., Finanger, Erika L., Rooney, William D., Kim, Sarah, Wang, Dah‐Jyuu, Lott, Donovan J., Senesac, Claudia R., Walter, Glenn A., Sweeney, H. Lee, Vandenborne, Krista

“…Objective Magnetic resonance (MR) measures of muscle quality are highly sensitive to disease progression and predictive of meaningful functional milestones in…”
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Imaging white matter in human brainstem by Ford, Anastasia A, Colon-Perez, Luis, Triplett, William T, Gullett, Joseph M, Mareci, Thomas H, Fitzgerald, David B

“…The human brainstem is critical for the control of many life-sustaining functions, such as consciousness, respiration, sleep, and transfer of sensory and motor…”
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MR biomarkers predict clinical function in Duchenne muscular dystrophy by Barnard, Alison M., Willcocks, Rebecca J., Triplett, William T., Forbes, Sean C., Daniels, Michael J., Chakraborty, Saptarshi, Lott, Donovan J., Senesac, Claudia R., Finanger, Erika L., Harrington, Ann T., Tennekoon, Gihan, Arora, Harneet, Wang, Dah-Jyuu, Sweeney, H. Lee, Rooney, William D., Walter, Glenn A., Vandenborne, Krista

“…OBJECTIVETo investigate the potential of lower extremity magnetic resonance (MR) biomarkers to serve as endpoints in clinical trials of therapeutics for…”
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Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort by Willcocks, Rebecca J., Rooney, William D., Triplett, William T., Forbes, Sean C., Lott, Donovan J., Senesac, Claudia R., Daniels, Michael J., Wang, Dah-Jyuu, Harrington, Ann T., Tennekoon, Gihan I., Russman, Barry S., Finanger, Erika L., Byrne, Barry J., Finkel, Richard S., Walter, Glenn A., Sweeney, H. Lee, Vandenborne, Krista

“…Objective The aim of this study was to describe Duchenne muscular dystrophy (DMD) disease progression in the lower extremity muscles over 12 months using…”
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Modeling disease trajectory in Duchenne muscular dystrophy by Rooney, William D., Berlow, Yosef A., Triplett, William T., Forbes, Sean C., Willcocks, Rebecca J., Wang, Dah-Jyuu, Arpan, Ishu, Arora, Harneet, Senesac, Claudia, Lott, Donovan J., Tennekoon, Gihan, Finkel, Richard, Russman, Barry S., Finanger, Erika L., Chakraborty, Saptarshi, O'Brien, Elliott, Moloney, Brendan, Barnard, Alison, Sweeney, H. Lee, Daniels, Michael J., Walter, Glenn A., Vandenborne, Krista

“…OBJECTIVETo quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles. METHODSMRI…”
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Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS by Arpan, Ishu, Willcocks, Rebecca J, Forbes, Sean C, Finkel, Richard S, Lott, Donovan J, Rooney, William D, Triplett, William T, Senesac, Claudia R, Daniels, Michael J, Byrne, Barry J, Finanger, Erika L, Russman, Barry S, Wang, Dah-Jyuu, Tennekoon, Gihan I, Walter, Glenn A, Sweeney, H.L, Vandenborne, Krista

“…OBJECTIVE:To evaluate the effects of corticosteroids on the lower extremity muscles in boys with Duchenne muscular dystrophy (DMD) using MRI and magnetic…”
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Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI by Barnard, Alison M., Lott, Donovan J., Batra, Abhinandan, Triplett, William T., Willcocks, Rebecca J., Forbes, Sean C., Rooney, William D., Daniels, Michael J., Smith, Barbara K., Vandenborne, Krista, Walter, Glenn A.

“…Expiratory muscle weakness and impaired airway clearance are early signs of respiratory dysfunction in Duchenne muscular dystrophy (DMD), a degenerative muscle…”
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Imaging respiratory muscle quality and function in Duchenne muscular dystrophy by Barnard, Alison M., Lott, Donovan J., Batra, Abhinandan, Triplett, William T., Forbes, Sean C., Riehl, Samuel L., Willcocks, Rebecca J., Smith, Barbara K., Vandenborne, Krista, Walter, Glenn A.

“…Objective Duchenne muscular dystrophy (DMD) is characterized by damage to muscles including the muscles involved in respiration. Dystrophic muscles become weak…”
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Five multivariate Duchenne muscular dystrophy progression models bridging six-minute walk distance and MRI relaxometry of leg muscles by Yoon, Deok Yong, Daniels, Michael J, Willcocks, Rebecca J, Triplett, William T, Morales, Juan Francisco, Walter, Glenn A, Rooney, William D, Vandenborne, Krista, Kim, Sarah

“…The study aimed to provide quantitative information on the utilization of MRI transverse relaxation time constant (MRI-T ) of leg muscles in DMD clinical…”
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Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort by Forbes, Sean C, Arora, Harneet, Willcocks, Rebecca J, Triplett, William T, Rooney, William D, Barnard, Alison M, Alabasi, Umar, Wang, Dah-Jyuu, Lott, Donovan J, Senesac, Claudia R, Harrington, Ann T, Finanger, Erika L, Tennekoon, Gihan I, Brandsema, John, Daniels, Michael J, Sweeney, H Lee, Walter, Glenn A, Vandenborne, Krista

“…Background Upper extremity MRI and proton MR spectroscopy are increasingly considered to be outcome measures in Duchenne muscular dystrophy (DMD) clinical…”
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Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history by Arora, Harneet, Willcocks, Rebecca J., Lott, Donovan J., Harrington, Ann T., Senesac, Claudia R., Zilke, Kirsten L., Daniels, Michael J., Xu, Dandan, Tennekoon, Gihan I., Finanger, Erika L., Russman, Barry S., Finkel, Richard S., Triplett, William T., Byrne, Barry J., Walter, Glenn A., Sweeney, H. Lee, Vandenborne, Krista

“…ABSTRACT Introduction: Tests of ambulatory function are common clinical trial endpoints in Duchenne muscular dystrophy (DMD). Using these tests, the ImagingDMD…”
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T2 mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy by Arpan, Ishu, Forbes, Sean C., Lott, Donovan J., Senesac, Claudia R., Daniels, Michael J., Triplett, William T., Deol, Jasjit K., Sweeney, H. Lee, Walter, Glenn A., Vandenborne, Krista

“…Skeletal muscles of children with Duchenne muscular dystrophy (DMD) show enhanced susceptibility to damage and progressive lipid infiltration, which contribute…”
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Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle by Triplett, William T., Baligand, Celine, Forbes, Sean C., Willcocks, Rebecca J., Lott, Donovan J., DeVos, Soren, Pollaro, Jim, Rooney, William D., Sweeney, H. Lee, Bönnemann, Carsten G., Wang, Dah-Jyuu, Vandenborne, Krista, Walter, Glenn A.

“…Purpose The relationship between fat fractions (FFs) determined based on multiple TE, unipolar gradient echo images and 1H magnetic resonance spectroscopy…”
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Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI by Barnard, Alison M., Hammers, David W., Triplett, William T., Kim, Sarah, Forbes, Sean C., Willcocks, Rebecca J., Daniels, Michael J., Senesac, Claudia R., Lott, Donovan J., Arpan, Ishu, Rooney, William D., Wang, Richard T., Nelson, Stanley F., Sweeney, H. Lee, Vandenborne, Krista, Walter, Glenn A.

“…Duchenne muscular dystrophy (DMD) is a progressive muscle degenerative disorder with a well-characterized disease phenotype but considerable interindividual…”
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Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial by Finkel, Richard S., Finanger, Erika, Vandenborne, Krista, Sweeney, H. Lee, Tennekoon, Gihan, Shieh, Perry B., Willcocks, Rebecca, Walter, Glenn, Rooney, William D., Forbes, Sean C., Triplett, William T., Yum, Sabrina W., Mancini, Maria, MacDougall, James, Fretzen, Angelika, Bista, Pradeep, Nichols, Andrew, Donovan, Joanne M.

“…•MoveDMD is a study of edasalonexent in boys with Duchenne muscular dystrophy.•Edasalonexent inhibits NF-κB and has potential to be effective regardless of…”
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Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy by Barnard, Alison M, Willcocks, Rebecca J, Finanger, Erika L, Daniels, Michael J, Triplett, William T, Rooney, William D, Lott, Donovan J, Forbes, Sean C, Wang, Dah-Jyuu, Senesac, Claudia R, Harrington, Ann T, Finkel, Richard S, Russman, Barry S, Byrne, Barry J, Tennekoon, Gihan I, Walter, Glenn A, Sweeney, H Lee, Vandenborne, Krista

“…To provide evidence for quantitative magnetic resonance (qMR) biomarkers in Duchenne muscular dystrophy by investigating the relationship between qMR measures…”
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Leg muscle MRI in identical twin boys with duchenne muscular dystrophy by Willcocks, Rebecca J., Triplett, William T., Lott, Donovan J., Forbes, Sean C., Batra, Abhinandan, Sweeney, H. Lee, Mendell, Jerry R., Vandenborne, Krista, Walter, Glenn A.

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Development of Contractures in DMD in Relation to MRI-Determined Muscle Quality and Ambulatory Function by Willcocks, Rebecca J, Barnard, Alison M, Wortman, Ryan J, Senesac, Claudia R, Lott, Donovan J, Harrington, Ann T, Zilke, Kirsten L, Forbes, Sean C, Rooney, William D, Wang, Dah-Jyuu, Finanger, Erika L, Tennekoon, Gihan I, Daniels, Michael J, Triplett, William T, Walter, Glenn A, Vandenborne, Krista

“…Joint contractures are common in boys and men with Duchenne muscular dystrophy (DMD), and management of contractures is an important part of care. The optimal…”
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