Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action

Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action

Superoxide dismutase (SOD) is a crucial enzyme responsible for the redox homeostasis inside the cell. As a part of the antioxidant defense system, it plays a pivotal role in the dismutation of the superoxide radicals (O2−) generated mainly by the oxidative phosphorylation, which would otherwise brin...

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Bibliographic Details
Published in:IUBMB life Vol. 76; no. 9; pp. 592 - 613
Main Authors: Panda, Biswajit, Tripathy, Ankita, Patra, Srimanta, Kullu, Bandana, Tabrez, Shams, Jena, Mrutyunjay
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-09-2024
Wiley Subscription Services, Inc
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Cancer
Enzymes
Epigenetics
Homeostasis
Humans
Malignancy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oxidation-Reduction
Oxidative phosphorylation
Oxidative Stress
Phosphorylation
Reactive oxygen species
Reactive Oxygen Species - metabolism
ROS
Signal Transduction
Superoxide dismutase
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Therapeutics
Tumors
Antioxidants
Superoxide dismutase
ROS
Therapeutics
Cancer
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Summary:Superoxide dismutase (SOD) is a crucial enzyme responsible for the redox homeostasis inside the cell. As a part of the antioxidant defense system, it plays a pivotal role in the dismutation of the superoxide radicals (O2−) generated mainly by the oxidative phosphorylation, which would otherwise bring out the redox dysregulation, leading to higher reactive oxygen species (ROS) generation and, ultimately, cell transformation, and malignancy. Several studies have shown the involvement of ROS in a wide range of human cancers. As SOD is the key enzyme in regulating ROS, any change, such as a transcriptional change, epigenetic remodeling, functional alteration, and so forth, either activates the proto‐oncogenes or aberrant signaling cascades, which results in cancer. Interestingly, in some cases, SODs act as tumor promoters instead of suppressors. Furthermore, SODs have also been known to switch their role during tumor progression. In this review, we have tried to give a comprehensive account of SODs multifactorial role in various human cancers so that SODs‐based therapeutic strategies could be made to thwart cancers.
Bibliography:Biswajit Panda, Ankita Tripathy and Srimanta Patra contributed equally to this work.
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ISSN:1521-6543
1521-6551
1521-6551
DOI:10.1002/iub.2821