Search Results - "Tripathi, Timir"

Advances in vaccines: revolutionizing disease prevention by Tripathi, Timir

“…Vaccines have revolutionized modern medicine by preventing infectious diseases and safeguarding public health. This Collection showcases cutting-edge research…”
Get full text

One year update on the COVID-19 pandemic: Where are we now? by Mishra, Sanjay Kumar, Tripathi, Timir

“…•COVID-19 pandemic has sparked a research revolution to understand the disease and find a cure.•The past year has seen rapid advances in understanding the…”
Get full text

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition by Subedi, Sushma, Sasidharan, Santanu, Nag, Niharika, Saudagar, Prakash, Tripathi, Timir

“…Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's disease, etc. are caused by inclusions and plaques containing…”
Get full text

Aminoacyl-tRNA synthetases: Structure, function, and drug discovery by Rajendran, Vijayakumar, Kalita, Parismita, Shukla, Harish, Kumar, Awanish, Tripathi, Timir

“…Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation reaction by covalently linking an amino acid to its cognate tRNA in the…”
Get full text

Autophagy Modulation as a Treatment of Amyloid Diseases by Mputhia, Zoe, Hone, Eugene, Tripathi, Timir, Sargeant, Tim, Martins, Ralph, Bharadwaj, Prashant

“…Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous…”
Get full text

Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility by Shukla, Harish, Shukla, Rohit, Sonkar, Amit, Pandey, Tripti, Tripathi, Timir

“…Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the glyoxylate shunt. In the present investigation, we studied the…”
Get full text

Identification and characterization of cytosolic malate dehydrogenase from the liver fluke Fasciola gigantica by Chetri, Purna Bahadur, Shukla, Rohit, Tripathi, Timir

“…The liver fluke zoonoses, Fasciola spp. are parasitic helminths infecting humans and animals globally. Recent sequencing of the genome of Fasciola gigantica…”
Get full text

Genome-wide identification and characterization of eukaryotic protein kinases by Das, Kanhu Charan, Kalita, Parismita, Tripathi, Timir

“…The tropical liver fluke,   is a food-borne parasite responsible for the hepatobiliary disease fascioliasis. The recent completion of   genome sequencing by…”
Get full text

High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: implications for potential resistance by Padhi, Aditya K., Shukla, Rohit, Saudagar, Prakash, Tripathi, Timir

“…The use of remdesivir to treat COVID-19 will likely continue before clinical trials are completed. Due to the lengthening pandemic and evolving nature of the…”
Get full text

Current and novel therapeutic molecules and targets in Alzheimer's disease by Kumar, Ashwini, Nisha, Chaluveelaveedu Murleedharan, Silakari, Chitrangda, Sharma, Isha, Anusha, Kanukanti, Gupta, Nityasha, Nair, Prateek, Tripathi, Timir, Kumar, Awanish

“…Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline, i.e., dementia. The…”
Get full text

Phospho-Tau Impairs Nuclear-Cytoplasmic Transport by Tripathi, Timir, Prakash, Jay, Shav-Tal, Yaron

“…Aggregation of hyperphosphorylated tau is the hallmark of several tauopathies, including Alzheimer’s disease (AD). Although the mechanism underlying…”
Get full text

Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase by Nisha, Chaluveelaveedu Murleedharan, Kumar, Ashwini, Nair, Prateek, Gupta, Nityasha, Silakari, Chitrangda, Tripathi, Timir, Kumar, Awanish

“…Amyloidogenic pathway in Alzheimer’s disease (AD) involves breakdown of APP by β-secretase followed by γ-secretase and results in formation of amyloid beta…”
Get full text

Characterization of a Highly pH Stable Chi-Class Glutathione S-Transferase from Synechocystis PCC 6803 by Pandey, Tripti, Singh, Sudhir Kumar, Chhetri, Gaurav, Tripathi, Timir, Singh, Arvind Kumar

“…Glutathione S-transferases (GSTs) are multifunctional enzymes present in virtually all organisms. Besides having an essential role in cellular detoxification,…”
Get full text

Computational Protein Design for COVID-19 Research and Emerging Therapeutics by Kalita, Parismita, Tripathi, Timir, Padhi, Aditya K.

“…As the world struggles with the ongoing COVID-19 pandemic, unprecedented obstacles have continuously been traversed as new SARS-CoV-2 variants continually…”
Get full text

Therapeutic p28 peptide targets essential H1N1 influenza virus proteins: insights from docking and molecular dynamics simulations by Sasidharan, Santanu, Gosu, Vijayakumar, Shin, Donghyun, Nath, Subhradip, Tripathi, Timir, Saudagar, Prakash

“…The H1N1 influenza virus causes a severe disease that affects the human respiratory tract leading to millions of deaths every year. At present, certain…”
Get full text

Critical Insight into Plausible Acquired Tocopherol Pathway in Neglected Human Trypanosomatids by Sasidharan, Santanu, Tripathi, Timir, Saudagar, Prakash

“…Despite global therapeutic advancements, tropical parasitic infections like trypanosomiasis and leishmaniasis continue to be a major health concern in…”
Get full text

An efficient protocol to enhance recombinant protein expression using ethanol in Escherichia coli by Chhetri, Gaurav, Kalita, Parismita, Tripathi, Timir

“…Bacterial cells can be engineered to express non-native genes, resulting in the production of, recombinant proteins, which have various biotechnological and…”
Get full text

Delineating the Structure–Dynamics–Binding Differences among BA.1, BA.4/5, and BF.7 SARS-CoV‑2 Variants through Atomistic Simulations: Correlation with Structural and Epidemiological Features by Joshi, Aryaman, Maurya, Shweata, Mahale, Atharva, Rath, Soumya Lipsa, Tripathi, Timir, Padhi, Aditya K.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus possessing a spike (S) protein that facilitates the entry of the virus into human…”
Get full text

Draft Genome of the Liver Fluke Fasciola gigantica by Pandey, Tripti, Ghosh, Arpita, Todur, Vivek N, Rajendran, Vijayakumar, Kalita, Parismita, Kalita, Jupitara, Shukla, Rohit, Chetri, Purna B, Shukla, Harish, Sonkar, Amit, Lyngdoh, Denzelle Lee, Singh, Radhika, Khan, Heena, Nongkhlaw, Joplin, Das, Kanhu Charan, Tripathi, Timir

“…Fascioliasis, a neglected foodborne disease caused by liver flukes (genus Fasciola), affects more than 200 million people worldwide. Despite technological…”
Get full text

Portrait of the Intrinsically Disordered Side of the HTLV‑1 Proteome by Lyngdoh, Denzelle L, Shukla, Harish, Sonkar, Amit, Anupam, Rajaneesh, Tripathi, Timir

“…Intrinsically disordered proteins (IDPs) lack an ordered 3D structure. These proteins contain one or more intrinsically disordered protein regions (IDPRs)…”
Get full text