Search Results - "Tripathi, Abhai K"

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis by Bakshi, Rahul P., Tatham, Lee M., Savage, Alison C., Tripathi, Abhai K., Mlambo, Godfree, Ippolito, Matthew M., Nenortas, Elizabeth, Rannard, Steve P., Owen, Andrew, Shapiro, Theresa A.

“…Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a…”
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A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission by Schleicher, Tyler R., Yang, Jing, Freudzon, Marianna, Rembisz, Alison, Craft, Samuel, Hamilton, Madeleine, Graham, Morven, Mlambo, Godfree, Tripathi, Abhai K., Li, Yue, Cresswell, Peter, Sinnis, Photini, Dimopoulos, George, Fikrig, Erol

“…The key step during the initiation of malaria is for motile Plasmodium parasites to exit the host dermis and infect the liver. During transmission, the…”
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restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells by Avril, Marion, Tripathi, Abhai K, Brazier, Andrew J, Andisi, Cheryl, Janes, Joel H, Soma, Vijaya L, Sullivan, David J, Bull, Peter C, Stins, Monique F, Smith, Joseph D

“…Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but specific interactions involved in cerebral homing of infected…”
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Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum by Batugedara, Gayani, Lu, Xueqing M., Hristov, Borislav, Abel, Steven, Chahine, Zeinab, Hollin, Thomas, Williams, Desiree, Wang, Tina, Cort, Anthony, Lenz, Todd, Thompson, Trevor A., Prudhomme, Jacques, Tripathi, Abhai K., Xu, Guoyue, Cudini, Juliana, Dogga, Sunil, Lawniczak, Mara, Noble, William Stafford, Sinnis, Photini, Le Roch, Karine G.

“…The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion…”
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Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito by Balta, Victoria A., Stiffler, Deborah, Sayeed, Abeer, Tripathi, Abhai K., Elahi, Rubayet, Mlambo, Godfree, Bakshi, Rahul P., Dziedzic, Amanda G., Jedlicka, Anne E., Nenortas, Elizabeth, Romero-Rodriguez, Keyla, Canonizado, Matthew A., Mann, Alexis, Owen, Andrew, Sullivan, David J., Prigge, Sean T., Sinnis, Photini, Shapiro, Theresa A.

“…Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical vaccine” for malaria, combining drug efficacy with vaccine…”
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Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity by Sanders, Natalie G, Sullivan, David J, Mlambo, Godfree, Dimopoulos, George, Tripathi, Abhai K

“…Discovery of transmission blocking compounds is an important intervention strategy necessary to eliminate and eradicate malaria. To date only a small number of…”
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mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum by Hayashi, Clifford T. H., Cao, Yi, Clark, Leor C., Tripathi, Abhai K., Zavala, Fidel, Dwivedi, Garima, Knox, James, Alameh, Mohamad-Gabriel, Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Kumar, Nirbhay

“…Malaria is a deadly disease responsible for between 550,000 and 627,000 deaths annually. There is a pressing need to develop vaccines focused on malaria…”
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The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization by Pisciotta, John M, Coppens, Isabelle, Tripathi, Abhai K, Scholl, Peter F, Shuman, Joel, Bajad, Sunil, Shulaev, Vladimir, Sullivan, Jr, David J

“…The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin is…”
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Plasmodium falciparum—Infected Erythrocytes Decrease the Integrity of Human Blood-Brain Barrier Endothelial Cell Monolayers by Tripathi, Abhai K., Sullivan, David J., Stins, Monique F.

“…Background. Central to the pathologic progression of human cerebral malaria (CM) is sequestration of Plasmodium falciparum—infected red blood cells (Pf-IRBCs)…”
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Plasmodium falciparum-Infected Erythrocytes Increase Intercellular Adhesion Molecule 1 Expression on Brain Endothelium through NF-κB by Tripathi, Abhai K, Sullivan, David J, Stins, Monique F

“…Sequestration of Plasmodium falciparum-infected erythrocytes (Pf-IRBC) in postcapillary brain endothelium is a hallmark of cerebral malaria (CM) pathogenesis…”
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Plasmodium sporozoite shows distinct motility patterns in responses to three-dimensional environments by Liu, Zhenhui, Li, Songman, Anantha, Pooja, Thanakornsombut, Tassanee, Wu, Lintong, Chen, Junjie, Tsuchiya, Ryohma, Tripathi, Abhai K., Chen, Yun, Barman, Ishan

“…During malaria infection, Plasmodium sporozoites, the fast-moving stage of the parasite, are injected by a mosquito into the skin of the mammalian host. In the…”
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Correction: Cao et al. Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission. Vaccines 2022, 10 , 1134 by Cao, Yi, Hayashi, Clifford T H, Zavala, Fidel, Tripathi, Abhai K, Simonyan, Hayk, Young, Colin N, Clark, Leor C, Usuda, Yukari, Van Parys, Jacob M, Kumar, Nirbhay

“…The authors would like to make the following corrections to this published paper [...]…”
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Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model by Ferrer, Patricia, Tripathi, Abhai K, Clark, Martha A, Hand, Carla Cerami, Rienhoff, Jr, Hugh Young, Sullivan, Jr, David J

“…Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use is limited by…”
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Effective Functional Immunogenicity of a DNA Vaccine Combination Delivered via In Vivo Electroporation Targeting Malaria Infection and Transmission by Cao, Yi, Hayashi, Clifford T H, Zavala, Fidel, Tripathi, Abhai K, Simonyan, Hayk, Young, Colin N, Clark, Leor C, Usuda, Yukari, Van Parys, Jacob M, Kumar, Nirbhay

“…Plasmodium falciparum circumsporozoite protein (PfCSP) and Pfs25 are leading candidates for the development of pre-erythrocytic and transmission-blocking…”
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Molecular Markers of Radiation Induced Attenuation in Intrahepatic Plasmodium falciparum Parasites by Oakley, Miranda S, Verma, Nitin, Zheng, Hong, Anantharaman, Vivek, Takeda, Kazuyo, Gao, Yamei, Myers, Timothy G, Pham, Phuong Thao, Mahajan, Babita, Kumar, Nirbhay, Sangweme, Davison, Tripathi, Abhai K, Mlambo, Godfree, Aravind, L, Kumar, Sanjai

“…Experimental immunization with radiation attenuated sporozoites (RAS) and genetically attenuated sporozoites has proved to be a promising approach for malaria…”
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A no film slot blot for the detection of developing P. falciparum oocysts in mosquitoes by Grabias, Bryan, Verma, Nitin, Zheng, Hong, Tripathi, Abhai K, Mlambo, Godfree, Morin, Merribeth J, Locke, Emily, Kumar, Sanjai

“…Non-microscopy-based assays for sensitive and rapid detection of Plasmodium infection in mosquitoes are needed to allow rapid and high throughput measurement…”
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Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum by Hayashi, Clifford T. H., Cao, Yi, Clark, Leor C., Tripathi, Abhai K., Zavala, Fidel, Dwivedi, Garima, Knox, James, Alameh, Mohamad-Gabriel, Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Kumar, Nirbhay

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Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding by Tripathi, Abhai K, Mlambo, Godfree, Kanatani, Sachie, Sinnis, Photini, Dimopoulos, George

“…Malaria remains one of the most important public health problems, causing significant morbidity and mortality. Malaria is a mosquito borne disease transmitted…”
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Screening the Pathogen Box for Inhibition of Plasmodium falciparum Sporozoite Motility Reveals a Critical Role for Kinases in Transmission Stages by Kanatani, Sachie, Elahi, Rubayet, Kanchanabhogin, Sukanat, Vartak, Natasha, Tripathi, Abhai K, Prigge, Sean T, Sinnis, Photini

“…As the malaria parasite becomes resistant to every drug that we develop, the identification and development of novel drug candidates are essential. Many…”
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Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax by Cao, Yi, Hayashi, Clifford T.H., Araujo, Maisa da Silva, Tripathi, Abhai K., Andrade, Alice Oliveira, Medeiros, Jansen Fernandes, Vinetz, Joseph, Kumar, Nirbhay

“…•Combination of TBV antigens encoded by DNA vaccines elicit Plasmodium species-specific transmission-blocking antibodies.•Immunogenicity of individual antigen…”
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