Search Results - "Trip, MD"

Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: A 12-week, multicenter, randomized, double-blind, controlled trial by Huijgen, Roeland, MD, Abbink, Evertine J., MD, PhD, Bruckert, Eric, MD, Stalenhoef, Anton F.H., MD, PhD, FRCP, Imholz, Ben P.M., MD, PhD, Durrington, Paul N., MD, FMedSci, Trip, M.D., MD, PhD, Eriksson, Mats, MD, PhD, Visseren, Frank L.J., MD, PhD, Schaefer, Juergen R., MD, Kastelein, John J.P., MD, PhD

“…Abstract Background: Familial hypercholesterolemia (FH) has been associated with increased cardiovascular risk when untreated or when normal LDL-C…”
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Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies by Sarwar, Nadeem, Butterworth, Adam S, Freitag, Daniel F, Gregson, John, Willeit, Peter, Gorman, Donal N, Gao, Pei, Saleheen, Danish, Rendon, Augusto, Nelson, Christopher P, Braund, Peter S, Hall, Alistair S, Chasman, Daniel I, Tybjærg-Hansen, Anne, Chambers, John C, Benjamin, Emelia J, Franks, Paul W, Clarke, Robert, Wilde, Arthur A M, Trip, Mieke D, Steri, Maristella, Witteman, Jacqueline C M, Qi, Lu, van der Schoot, C Ellen, de Faire, Ulf, Erdmann, Jeanette, Stringham, Heather M, Koenig, Wolfgang, Rader, Daniel J, Melzer, David, Reich, David, Psaty, Bruce M, Kleber, Marcus E, Panagiotakos, Demosthenes B, Willeit, Johann, Wennberg, Patrik, Woodward, Mark, Adamovic, Svetlana, Rimm, Eric B, Meade, Tom W, Gillum, Richard F, Shaffer, Jonathan A, Hofman, Albert, Onat, Altan, Sundström, Johan, Wassertheil-Smoller, Sylvia, Mellström, Dan, Gallacher, John, Cushman, Mary, Tracy, Russell P, Kauhanen, Jussi, Karlsson, Magnus, Salonen, Jukka T, Wilhelmsen, Lars, Amouyel, Philippe, Cantin, Bernard, Best, Lyle G, Ben-Shlomo, Yoav, Manson, JoAnn E, Davey-Smith, George, de Bakker, Paul I W, O'Donnell, Christopher J, Wilson, James F, Wilson, Anthony G, Assimes, Themistocles L, Jansson, John-Olov, Ohlsson, Claes, Tivesten, Åsa, Ljunggren, Östen, Reilly, Muredach P, Hamsten, Anders, Ingelsson, Erik, Cambien, Francois, Hung, Joseph, Thomas, G Neil, Boehnke, Michael, Schunkert, Heribert, Asselbergs, Folkert W, Kastelein, John J P, Gudnason, Vilmundur, Salomaa, Veikko, Harris, Tamara B, Kooner, Jaspal S, Allin, Kristine H, Nordestgaard, Børge G, Hopewell, Jemma C, Goodall, Alison H, Ridker, Paul M, Hólm, Hilma, Watkins, Hugh, Ouwehand, Willem H, Samani, Nilesh J, Kaptoge, Stephen, Di Angelantonio, Emanuele, Harari, Olivier, Danesh, John

“…Summary Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6…”
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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease by Peden, John F., Hopewell, Jemma C., Saleheen, Danish, Chambers, John C., Hager, Jorg, Collins, Rory, Danesh, John, Elliott, Paul, Farrall, Martin, Stirrups, Kathy, Zhang, Weihua, Hamsten, Anders, Parish, Sarah, Lathrop, Mark, Watkins, Hugh, Clarke, Robert, Deloukas, Panos, Kooner, Jaspal S., Goel, Anuj, Ongen, Halit, Strawbridge, Rona J., Heath, Simon, Mälarstig, Anders, Helgadottir, Anna, Öhrvik, John, Murtaza, Muhammed, Potter, Simon, Hunt, Sarah E., Delepine, Marc, Jalilzadeh, Shapour, Axelsson, Tomas, Syvänen, Ann-Christine, Gwilliam, Rhian, Bumpstead, Suzannah, Gray, Emma, Edkins, Sarah, Folkersen, Lasse, Kyriakou, Theodosios, Franco-Cereceda, Anders, Gabrielsen, Anders, Seedorf, Udo, Eriksson, Per, Offer, Alison, Bowman, Louise, Sleight, Peter, Armitage, Jane, Peto, Richard, Abecasis, Goncalo, Ahmed, Nabeel, Caulfield, Mark, Donnelly, Peter, Froguel, Philippe, Kooner, Angad S., McCarthy, Mark I., Samani, Nilesh J., Scott, James, Sehmi, Joban, Silveira, Angela, Hellenius, Mai-Lis, van't Hooft, Ferdinand M., Olsson, Gunnar, Rust, Stephan, Assmann, Gerd, Barlera, Simona, Tognoni, Gianni, Franzosi, Maria Grazia, Linksted, Pamela, Green, Fiona R., Rasheed, Asif, Zaidi, Moazzam, Shah, Nabi, Samuel, Maria, Mallick, Nadeem H., Azhar, Muhammad, Zaman, Khan S., Samad, Abdus, Ishaq, Mohammad, Gardezi, Ali R., Frossard, Philippe M., Spector, Tim, Peltonen, Leena, Nieminen, Markku S., Sinisalo, Juha, Salomaa, Veikko, Ripatti, Samuli, Bennett, Derrick, Leander, Karin, Gigante, Bruna, de Faire, Ulf, Pietri, Silvia, Gori, Francesca, Marchioli, Roberto, Sivapalaratnam, Suthesh, Kastelein, John J. P., Trip, Mieke D., Theodoraki, Eirini V., Dedoussis, George V., Engert, Jamie C., Yusuf, Salim, Anand, Sonia S.

“…The Coronary Artery Disease Genetics Consortium report a meta-analysis of genome-wide association studies for coronary artery disease (CAD) in discovery and…”
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Large-scale gene-centric analysis identifies novel variants for coronary artery disease by Butterworth, AS, Farrall, M, Hardwick, RJ, Saleheen, D, Peden, JF, Soranzo, N, Chambers, JC, Sivapalaratnam, S, Kleber, ME, Klopp, N, Erdmann, J, Assimes, TL, Ball, SG, Balmforth, AJ, Barnes, TA, Basart, H, Baumert, J, Bezzina, CR, Boerwinkle, E, Boehm, BO, Brocheton, J, Bugert, P, Cambien, F, Clarke, R, Codd, V, Collins, R, Couper, D, Cupples, LA, de Jong, JS, Diemert, P, Ejebe, K, Elbers, CC, Elliott, P, Fornage, M, Franzosi, MG, Frossard, P, Garner, S, Goel, A, Goodall, AH, Hengstenberg, C, Hunt, SE, Kastelein, JJP, Klungel, OH, Kluter, H, Koch, K, Konig, IR, Kooner, AS, Laaksonen, R, Lathrop, M, Li, MY, Liu, K, McPherson, R, Musameh, MD, Musani, S, Nelson, CP, O'Donnell, CJ, Ongen, H, Papanicolaou, G, Peters, A, Peters, BJM, Potter, S, Psaty, BM, Qu, LM, Rader, DJ, Rasheed, A, Rice, C, Scott, J, Seedorf, U, Sehmi, JS, Sotoodehnia, N, Stark, K, Stephens, J, van der Schoot, CE, van der Schouw, YT, Tomaszewski, M, van der Harst, P, Vasan, RS, Wilde, AAM, Willenborg, C, Winkelmann, BR, Zaidi, M, Zhang, WH, Ziegler, A, de Bakker, PIW, Koenig, W, Marz, W, Trip, MD, Reilly, MP, Kathiresan, S, Schunkert, H, Hamsten, A, Hall, AS, Kooner, JS, Thompson, SG, Thompson, JR, Deloukas, P, Ouwehand, WH, Watkins, H, Danesh, J, Samani, NJ

“…Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies,…”
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Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP) : a prospective, randomised, double-blind trial by SMILDE, T. J, VAN WISSEN, S, WOLLERSHEIM, H, TRIP, M. D, KASTELEIN, J. J. P, STALENHOEF, A. F. H

“…High LDL-cholesterol is a risk factor for atherosclerosis. We aimed to determine whether aggressive cholesterol lowering with statins was more effective than…”
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ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia: The CAPTIVATE Randomized Trial by Meuwese, Marijn C, de Groot, Eric, Duivenvoorden, Raphaël, Trip, Mieke D, Ose, Leiv, Maritz, Frans J, Basart, Dick C. G, Kastelein, John J. P, Habib, Rafik, Davidson, Michael H, Zwinderman, Aeilko H, Schwocho, Lee R, Stein, Evan A, CAPTIVATE Investigators, for the

“…CONTEXT Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was…”
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Effectiveness of Inhibition of Cholesteryl Ester Transfer Protein by JTT-705 in Combination With Pravastatin in Type II Dyslipidemia by Kuivenhoven, Jan Albert, de Grooth, Greetje J., Kawamura, Hitoshi, Klerkx, Anke H., Wilhelm, Francois, Trip, Mieke D., Kastelein, John J.P.

“…The inhibition of cholesteryl ester transfer protein (CETP) has recently been shown to effectively increase high-density lipoprotein (HDL) cholesterol. This…”
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Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility by Vergeer, Menno, Boekholdt, S Matthijs, Sandhu, Manjinder S, Ricketts, Sally L, Wareham, Nicholas J, Brown, Morris J, de Faire, Ulf, Leander, Karin, Gigante, Bruna, Kavousi, Maryam, Hofman, Albert, Uitterlinden, Andre G, van Duijn, Cornelia M, Witteman, Jacqueline C M, Jukema, J Wouter, Schadt, Eric E, van der Schoot, Ellen, Kastelein, John J P, Khaw, Kay-Tee, Dullaart, Robin P F, van Tol, Arie, Trip, Mieke D, Dallinga-Thie, Geesje M

“…In contrast to clear associations between variants in genes participating in low-density lipoprotein metabolism and cardiovascular disease risk, such…”
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The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients by Jansen, A. C. M., Aalst‐Cohen, E. S., Tanck, M. W., Trip, M. D., Lansberg, P. J., Liem, A. H., Roeters van Lennep, H. W. O., Sijbrands, E. J. G., Kastelein, J. J. P.

“… Objective.  To determine the contribution of classical risk factors to the development of cardiovascular disease (CVD) in patients with heterozygous familial…”
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Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels by Jakulj, Lily, Trip, Mieke D, Sudhop, Thomas, Bergmann, Klaus von, Kastelein, John J. P, Vissers, Maud N

“…Consumption of plant sterols and treatment with ezetimibe both reduce cholesterol absorption in the intestine. However, the mechanism of action differs between…”
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Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy by van Wissen, Sanne, Trip, Mieke D, Smilde, Tineke J, de Graaf, Jacqueline, Stalenhoef, Anton F.H, Kastelein, John J.P

“…Background: High sensitivity C-reactive protein (hs-CRP) has emerged as the best studied and most promising marker of inflammation in atherosclerotic vascular…”
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Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia by van Wissen, Sanne, Smilde, Tineke J., Trip, Mieke D., Stalenhoef, Anton F.H., Kastelein, John J.P.

“…In the 2-year Atorvastatin versus Simvastatin on Atherosclerosis Progression extension study, patients with familial hypercholesterolemia who continued to take…”
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Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease by TRIP, Mieke D, SMULDERS, Yvo M, WEGMAN, Jurgen J, XIAOFENG HU, BOER, Jolanda M. A, TEN BRINK, Jacoline B, ZWINDERMAN, Aeilko H, KASTELEIN, John J. P, FESKENS, Edith J. M, BERGEN, Arthur A. B

“…Pseudoxanthoma elasticum (PXE) is an inborn disorder of the connective tissue with specific skin, ocular, and cardiovascular disease (CVD) manifestations…”
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Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia by van Wissen, S, Smilde, T J, Trip, M D, de Boo, Th, Kastelein, J J P, Stalenhoef, A F H

“…Background: Raised plasma lipoprotein(a) (Lp(a)) is associated with increased risk of cardiovascular disease. It is unknown whether increased Lp(a) is an…”
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Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia by Kastelein, JJP, Akdim, F, Stroes, ESG, Zwinderman, AH, Bots, ML, Stalenhoef, AFH, Visseren, FLJ, Sijbrands, EJG, Trip, MD, Stein, EA, Gaudet, D, Duivenvoorden, R, Veltri, EP, Marais, AD, de Groot, E

“…Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia Original Article, N Engl J Med 2008:358;1431-1443.. In the list of authors' affiliations…”
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The Right Ventricle Explains Sex Differences in Survival in Idiopathic Pulmonary Arterial Hypertension by Jacobs, Wouter, MD, van de Veerdonk, Mariëlle C., MD, Trip, Pia, MD, de Man, Frances, PhD, Heymans, Martijn W., PhD, Marcus, Johannes T., PhD, Kawut, Steven M., MD, FCCP, Bogaard, Harm-Jan, MD, PhD, Boonstra, Anco, MD, PhD, Vonk Noordegraaf, Anton, MD, PhD, FCCP

“…Background Male sex is an independent predictor of worse survival in pulmonary arterial hypertension (PAH). This finding might be explained by more severe…”
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Abnormalities in liver function and coagulation profile following the Fontan procedure by van Nieuwenhuizen, R C, Peters, M, Lubbers, L J, Trip, M D, Tijssen, J G P, Mulder, B J M

“…OBJECTIVE To investigate liver function and coagulation disorders in patients with a Fontan circulation at different time intervals after surgery. DESIGN…”
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Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease by Heikens, Janneke, Ubbink, Mathilde C., van der Pal, Heleen P. J., Bakker, Piet J. M., Fliers, Eric, Smilde, Tineke J., Kastelein, John J. P., Trip, Mieke D.

“…BACKGROUND Cranial irradiation for children with brain tumors frequently leads to neuroendocrine deficiencies. In this controlled study, the authors…”
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Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension by Trip, Pia, MD, Kind, Taco, MD, PhD, van de Veerdonk, Marielle C., MD, Marcus, Johannes T., PhD, de Man, Frances S., PhD, Westerhof, Nico, PhD, Vonk-Noordegraaf, Anton, MD, PhD

“…Background End-systolic elastance (Ees ), a load-independent measure of ventricular function, is of clinical interest for studies of the right ventricle (RV)…”
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Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia by Netea, M. G., Hijmans, A., Van Wissen, S., Smilde, T. J., Trip, M. D., Kullberg, B. J., De Boo, T., Van der Meer, J. W. M., Kastelein, J. J. P., Stalenhorf, A. F. H.

“…Background  Toll‐like receptor‐4 (TLR4) is a major receptor for inflammatory stimuli potentially involved in the pathogenesis of atherosclerosis, such as…”
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