Search Results - "Trino, Stefania"

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy by Trino, Stefania, Lamorte, Daniela, Caivano, Antonella, De Luca, Luciana, Sgambato, Alessandro, Laurenzana, Ilaria

“…In the era of precision medicine, liquid biopsy is becoming increasingly important in oncology. It consists in the isolation and analysis of tumor-derived…”
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MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia by Trino, Stefania, Lamorte, Daniela, Caivano, Antonella, Laurenzana, Ilaria, Tagliaferri, Daniela, Falco, Geppino, Del Vecchio, Luigi, Musto, Pellegrino, De Luca, Luciana

“…Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which are characterized by relevant heterogeneity in terms of phenotypic,…”
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MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation by De Luca, Luciana, Trino, Stefania, Laurenzana, Ilaria, Simeon, Vittorio, Calice, Giovanni, Raimondo, Stefania, Podestà, Marina, Santodirocco, Michele, Di Mauro, Lazzaro, La Rocca, Francesco, Caivano, Antonella, Morano, Annalisa, Frassoni, Francesco, Cilloni, Daniela, Del Vecchio, Luigi, Musto, Pellegrino

“…Hematopoietic stem cells (HSC), including umbilical cord blood CD34+ stem cells (UCB-CD34+), are used for the treatment of several diseases. Although different…”
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Mesenchymal Stem Cell Derived Extracellular Vesicles: A Role in Hematopoietic Transplantation? by De Luca, Luciana, Trino, Stefania, Laurenzana, Ilaria, Lamorte, Daniela, Caivano, Antonella, Del Vecchio, Luigi, Musto, Pellegrino

“…Mesenchymal stem cells (MSCs) are a heterogeneous cellular population containing different progenitors able to repair tissues, support hematopoiesis, and…”
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Acute Myeloid Leukemia Cells Functionally Compromise Hematopoietic Stem/Progenitor Cells Inhibiting Normal Hematopoiesis Through the Release of Extracellular Vesicles by Trino, Stefania, Laurenzana, Ilaria, Lamorte, Daniela, Calice, Giovanni, De Stradis, Angelo, Santodirocco, Michele, Sgambato, Alessandro, Caivano, Antonella, De Luca, Luciana

“…Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal disorder of hematopoietic stem/progenitor cells (HSPCs). It is not well known how…”
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DNA methylation of hematopoietic stem/progenitor cells from donor peripheral blood to patient bone marrow: implications for allogeneic hematopoietic stem cell transplantation by Laurenzana, Ilaria, De Luca, Luciana, Zoppoli, Pietro, Calice, Giovanni, Sgambato, Alessandro, Carella, Angelo Michele, Caivano, Antonella, Trino, Stefania

“…Allogeneic hematopoietic stem cell transplantation (AHSCT) is a life-saving treatment for selected hematological malignancies. So far, it remains unclear…”
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P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia by Trino, Stefania, De Luca, Luciana, Laurenzana, Ilaria, Caivano, Antonella, Del Vecchio, Luigi, Martinelli, Giovanni, Musto, Pellegrino

“…The tumor suppressor p53 is a canonical regulator of different biological functions, like apoptosis, cell cycle arrest, DNA repair, and genomic stability. This…”
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Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells by Caso, Alessia, Laurenzana, Ilaria, Lamorte, Daniela, Trino, Stefania, Esposito, Germana, Piccialli, Vincenzo, Costantino, Valeria

“…Smenamides are an intriguing class of peptide/polyketide molecules of marine origin showing antiproliferative activity against lung cancer Calu-1 cells at…”
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TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors by Condelli, Valentina, Piscazzi, Annamaria, Sisinni, Lorenza, Matassa, Danilo Swann, Maddalena, Francesca, Lettini, Giacomo, Simeon, Vittorio, Palladino, Giuseppe, Amoroso, Maria Rosaria, Trino, Stefania, Esposito, Franca, Landriscina, Matteo

“…Human BRAF-driven tumors are aggressive malignancies with poor clinical outcome and lack of sensitivity to therapies. TRAP1 is a HSP90 molecular chaperone…”
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Advances in Azorella glabra Wedd. Extract Research: In Vitro Antioxidant Activity, Antiproliferative Effects on Acute Myeloid Leukemia Cells and Bioactive Compound Characterization by Lamorte, Daniela, Faraone, Immacolata, Laurenzana, Ilaria, Trino, Stefania, Russo, Daniela, Rai, Dilip K., Armentano, Maria Francesca, Musto, Pellegrino, Sgambato, Alessandro, De Luca, Luciana, Milella, Luigi, Caivano, Antonella

“…Azorella glabra Wedd. (AG) is traditionally used to treat gonorrhea or kidney’s problems. The antioxidant, antidiabetic, anticholinesterase and in vitro…”
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Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells by Lamorte, Daniela, Faraone, Immacolata, Laurenzana, Ilaria, Milella, Luigi, Trino, Stefania, De Luca, Luciana, Del Vecchio, Luigi, Armentano, Maria Francesca, Sinisgalli, Chiara, Chiummiento, Lucia, Russo, Daniela, Bisaccia, Faustino, Musto, Pellegrino, Caivano, Antonella

“…Multiple myeloma (MM) is the second most common hematologic malignancy and, although the development of novel agents has improved survival of patients, to…”
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Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies by Caivano, Antonella, Falco, Geppino, Musto, Pellegrino, Ruggieri, Vitalba, Zoppoli, Pietro, Ambrosino, C., De Luca, Luciana, Trino, Stefania, Lamorte, Daniela, Laurenzana, Ilaria, Del Vecchio, Luigi

“…The bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells. Cancer…”
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Multiple Myeloma-Derived Extracellular Vesicles Impair Normal Hematopoiesis by Acting on Hematopoietic Stem and Progenitor Cells by Laurenzana, Ilaria, Trino, Stefania, Lamorte, Daniela, De Stradis, Angelo, Santodirocco, Michele, Sgambato, Alessandro, De Luca, Luciana, Caivano, Antonella

“…Multiple myeloma (MM) is characterized by the abnormal proliferation of clonal plasma cells (PCs) in bone marrow (BM). MM-PCs progressively occupy and likely…”
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DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation by Trino, Stefania, Zoppoli, Pietro, Carella, Angelo Michele, Laurenzana, Ilaria, Weisz, Alessandro, Memoli, Domenico, Calice, Giovanni, La Rocca, Francesco, Simeon, Vittorio, Savino, Lucia, Del Vecchio, Luigi, Musto, Pellegrino, Caivano, Antonella, De Luca, Luciana

“…Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative therapeutic approach for different hematological malignancies (HMs), and epigenetic…”
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Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine by Simeon, Vittorio, Todoerti, Katia, La Rocca, Francesco, Caivano, Antonella, Trino, Stefania, Lionetti, Marta, Agnelli, Luca, De Luca, Luciana, Laurenzana, Ilaria, Neri, Antonino, Musto, Pellegrino

“…Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease…”
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A case of acute promyelocytic leukemia variant with derivative chromosome 3 der(3)t(3;8) associated with 8q partial gain by Nozza, Filomena, Vona, Gabriella, Trino, Stefania, D'Auria, Fiorella, La Rocca, Francesco, Grieco, Vitina, Possidente, Luciana, De Luca, Luciana, Musto, Pellegrino

“…Acute promyelocytic leukemia (APL) is characterized by fusion of PML/RARα genes as a result of t(15;17)(q24;q21). APL is now one of the curable hematological…”
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A Pyrazolo[3,4- d ]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies by Laurenzana, Ilaria, Caivano, Antonella, La Rocca, Francesco, Trino, Stefania, De Luca, Luciana, D'Alessio, Francesca, Schenone, Silvia, Falco, Geppino, Botta, Maurizio, Del Vecchio, Luigi, Musto, Pellegrino

“…Molecular targeted therapies are based upon drugs acting on tumors by interfering with specific targets involved in growth and spread of cancer. Many targeted…”
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Autoimmune Cytopenias in Chronic Lymphocytic Leukemia by Musto, Pellegrino, De Martino, Laura, Condelli, Valentina, Trino, Stefania, La Rocca, Francesco, Guariglia, Roberto, D'Arena, Giovanni, De Feo, Vincenzo

“…The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic…”
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IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells by Notarangelo, Tiziana, Sisinni, Lorenza, Trino, Stefania, Calice, Giovanni, Simeon, Vittorio, Landriscina, Matteo

“…Thyroid carcinomas (TCs) bearing BRAF mutations represent approximately 26–53% of human thyroid malignancies and, differently from melanomas, are poorly…”
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High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders by Caivano, Antonella, Laurenzana, Ilaria, De Luca, Luciana, La Rocca, Francesco, Simeon, Vittorio, Trino, Stefania, D’Auria, Fiorella, Traficante, Antonio, Maietti, Maddalena, Izzo, Tiziana, D’Arena, Giovanni, Mansueto, Giovanna, Pietrantuono, Giuseppe, Laurenti, Luca, Musto, Pellegrino, Del Vecchio, Luigi

“…Many cell types release extracellular vesicles (EVs), including exosomes, microvesicles (MVs), and apoptotic bodies, which play a role in physiology and…”
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