Search Results - "Trinh, Quang M"

Next-generation sequencing identifies rare variants associated with Noonan syndrome by Chen, Peng-Chieh, Yin, Jiani, Yu, Hui-Wen, Yuan, Tao, Fernande, Minerva, Yung, Christina K., Trinh, Quang M., Peltekova, Vanya D., Reid, Jeffrey G., Tworog-Dube, Erica, Morgan, Margaret B., Muzny, Donna M., Stein, Lincoln, McPherson, John D., Roberts, Amy E., Gibbs, Richard A., Neel, Benjamin G., Kucherlapati, Raju

“…Noonan syndrome (NS) is a relatively common genetic disorder, characterized by typical facies, short stature, developmental delay, and cardiac abnormalities…”
Get full text

A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours by Hamed, Akram A., Kunz, Daniel J., El-Hamamy, Ibrahim, Trinh, Quang M., Subedar, Omar D., Richards, Laura M., Foltz, Warren, Bullivant, Garrett, Ware, Matthaeus, Vladoiu, Maria C., Zhang, Jiao, Raj, Antony M., Pugh, Trevor J., Taylor, Michael D., Teichmann, Sarah A., Stein, Lincoln D., Simons, Benjamin D., Dirks, Peter B.

“…Human cerebral cancers are known to contain cell types resembling the varying stages of neural development. However, the basis of this association remains…”
Get full text

ISOWN: accurate somatic mutation identification in the absence of normal tissue controls by Kalatskaya, Irina, Trinh, Quang M, Spears, Melanie, McPherson, John D, Bartlett, John M S, Stein, Lincoln

“…A key step in cancer genome analysis is the identification of somatic mutations in the tumor. This is typically done by comparing the genome of the tumor to…”
Get full text

Association between germline variants and somatic mutations in colorectal cancer by Barfield, Richard, Qu, Conghui, Steinfelder, Robert S., Zeng, Chenjie, Harrison, Tabitha A., Brezina, Stefanie, Buchanan, Daniel D., Campbell, Peter T., Casey, Graham, Gallinger, Steven, Giannakis, Marios, Gruber, Stephen B., Gsur, Andrea, Hsu, Li, Huyghe, Jeroen R., Moreno, Victor, Newcomb, Polly A., Ogino, Shuji, Phipps, Amanda I., Slattery, Martha L., Thibodeau, Stephen N., Trinh, Quang M., Toland, Amanda E., Hudson, Thomas J., Sun, Wei, Zaidi, Syed H., Peters, Ulrike

“…Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better…”
Get full text

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia by Shlush, Liran I., Zandi, Sasan, Mitchell, Amanda, Chen, Weihsu Claire, Brandwein, Joseph M., Gupta, Vikas, Kennedy, James A., Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., McLeod, Jessica L., Doedens, Monica, Medeiros, Jessie J. F., Marke, Rene, Kim, Hyeoung Joon, Lee, Kwon, McPherson, John D., Hudson, Thomas J., Pan-Leukemia Gene Panel Consortium, The HALT, Brown, Andrew M. K., Yousif, Fouad, Trinh, Quang M., Stein, Lincoln D., Minden, Mark D., Wang, Jean C. Y., Dick, John E.

“…In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly…”
Get full text

Molecular heterogeneity of non‐small cell lung carcinoma patient‐derived xenografts closely reflect their primary tumors by Wang, Dennis, Pham, Nhu‐An, Tong, Jiefei, Sakashita, Shingo, Allo, Ghassan, Kim, Lucia, Yanagawa, Naoki, Raghavan, Vibha, Wei, Yuhong, To, Christine, Trinh, Quang M., Starmans, Maud H.W., Chan‐Seng‐Yue, Michelle A., Chadwick, Dianne, Li, Lei, Zhu, Chang‐Qi, Liu, Ni, Li, Ming, Lee, Sharon, Ignatchenko, Vladimir, Strumpf, Dan, Taylor, Paul, Moghal, Nadeem, Liu, Geoffrey, Boutros, Paul C., Kislinger, Thomas, Pintilie, Melania, Jurisica, Igor, Shepherd, Frances A., McPherson, John D., Muthuswamy, Lakshmi, Moran, Michael F., Tsao, Ming‐Sound

“…Availability of lung cancer models that closely mimic human tumors remains a significant gap in cancer research, as tumor cell lines and mouse models may not…”
Get full text

Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis by Borozan, Ivan, Zaidi, Syed H, Harrison, Tabitha A, Phipps, Amanda I, Zheng, Jiayin, Lee, Stephen, Trinh, Quang M, Steinfelder, Robert S, Adams, Jeremy, Banbury, Barbara L, Berndt, Sonja I, Brezina, Stefanie, Buchanan, Daniel D, Bullman, Susan, Cao, Yin, Farris, 3rd, Alton B, Figueiredo, Jane C, Giannakis, Marios, Heisler, Lawrence E, Hopper, John L, Lin, Yi, Luo, Xuemei, Nishihara, Reiko, Mardis, Elaine R, Papadopoulos, Nickolas, Qu, Conghui, Reid, Emma E G, Thibodeau, Stephen N, Harlid, Sophia, Um, Caroline Y, Hsu, Li, Gsur, Andrea, Campbell, Peter T, Gallinger, Steven, Newcomb, Polly A, Ogino, Shuji, Sun, Wei, Hudson, Thomas J, Ferretti, Vincent, Peters, Ulrike

“…( ) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis. We characterized and its subspecies in colorectal…”
Get full text

Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature by Thomas, Claire E, Georgeson, Peter, Qu, Conghui, Steinfelder, Robert S, Buchanan, Daniel D, Song, Mingyang, Harrison, Tabitha A, Um, Caroline Y, Hullar, Meredith A, Jenkins, Mark A, Van Guelpen, Bethany, Lynch, Brigid M, Melaku, Yohannes Adama, Huyghe, Jeroen R, Aglago, Elom K, Berndt, Sonja I, Boardman, Lisa A, Campbell, Peter T, Cao, Yin, Chan, Andrew T, Drew, David A, Figueiredo, Jane C, French, Amy J, Giannakis, Marios, Goode, Ellen L, Gruber, Stephen B, Gsur, Andrea, Gunter, Marc J, Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Moreno, Victor, Murphy, Neil, Newcomb, Polly A, Newton, Christina C, Nowak, Jonathan A, Obón-Santacana, Mireia, Ogino, Shuji, Sun, Wei, Toland, Amanda E, Trinh, Quang M, Ugai, Tomotaka, Zaidi, Syed H, Peters, Ulrike, Phipps, Amanda I

“…The genotoxin colibactin causes a tumor single base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors association…”
Get full text

Spatiotemporal integration of molecular and anatomical data in virtual reality using semantic mapping by Soh, Jung, Turinsky, Andrei L, Trinh, Quang M, Chang, Jasmine, Sabhaney, Ajay, Dong, Xiaoli, Gordon, Paul Mk, Janzen, Ryan Pw, Hau, David, Xia, Jianguo, Wishart, David S, Sensen, Christoph W

“…We have developed a computational framework for spatiotemporal integration of molecular and anatomical datasets in a virtual reality environment. Using two…”
Get full text

Evaluating the predictive accuracy of curated biological pathways in a public knowledgebase by Wright, Adam J, Orlic-Milacic, Marija, Rothfels, Karen, Weiser, Joel, Trinh, Quang M, Jassal, Bijay, Haw, Robin A, Stein, Lincoln D

“…Reactome is a database of human biological pathways manually curated from the primary literature and peer-reviewed by experts. To evaluate the utility of…”
Get full text

Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer‐associated variants by Peltekova, Vanya D., Lemire, Mathieu, Qazi, Aamer M., Zaidi, Syed H. E., Trinh, Quang M., Bielecki, Ryszard, Rogers, Marianne, Hodgson, Lyndsey, Wang, Mike, D'Souza, David J. A., Zandi, Sasan, Chong, Taryne, Kwan, Jennifer Y. Y., Kozak, Krystian, Borja, Richard, Timms, Lee, Rangrej, Jagadish, Volar, Milica, Chan‐Seng‐Yue, Michelle, Beck, Timothy, Ash, Colleen, Lee, Shawna, Wang, Jianxin, Boutros, Paul C., Stein, Lincoln D., Dick, John E., Gryfe, Robert, McPherson, John D., Zanke, Brent W., Pollett, Aaron, Gallinger, Steven, Hudson, Thomas J.

“…A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome‐wide association study; this finding has…”
Get full text

Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE by Trinh, Quang M, Jen, Fei-Yang Arthur, Zhou, Ziru, Chu, Kar Ming, Perry, Marc D, Kephart, Ellen T, Contrino, Sergio, Ruzanov, Peter, Stein, Lincoln D

“…Funded by the National Institutes of Health (NIH), the aim of the Model Organism ENCyclopedia of DNA Elements (modENCODE) project is to provide the biological…”
Get full text

Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer by Grant, Robert C, Al-Sukhni, Wigdan, Borgida, Ayelet E, Holter, Spring, Kanji, Zaheer S, McPherson, Treasa, Whelan, Emily, Serra, Stefano, Trinh, Quang M, Peltekova, Vanya, Stein, Lincoln D, McPherson, John D, Gallinger, Steven

“…We sequenced 11 germline exomes from five families with familial pancreatic cancer (FPC). One proband had a germline nonsense variant in ATM with somatic loss…”
Get full text

Abstract 3131: Tumour spatial heterogeneity in breast cancer and the impact on clinical management by Bayani, Jane, Trinh, Quang M., Quintayo, Mary Anne, Crozier, Cheryl, Hopkins, Megan, Qiao, Jingping, Cheung, Alison, Mainprize, James, Morris, Quaid, Spears, Melanie, Yaffe, Martin, Stein, Lincoln, Bartlett, John M.

“…We recognize that many cancers are highly complex mixtures of sub-populations of cells, which are also influenced by their microenvironment. This heterogeneity…”
Get full text

Abstract PO-002: Revealing tumour spatial heterogeneity in breast cancer and the impact on clinical management by Bayani, Jane, Trinh, Quang M., Quintayo, Mary Anne, Crozier, Cheryl, Hopkins, Megan, Qiao, Jingping, Cheung, Alison, Mainprize, James G, Morris, Quaid, Spears, Melanie, Yaffe, Martin J., Stein, Lincoln D., Bartlett, John M.S.

“…Many cancers are highly complex mixtures of many sub-populations of cells, also influenced by their microenvironment. This heterogeneity explains, in part, why…”
Get full text

Body mass index and molecular subtypes of colorectal cancer by Murphy, Neil, Newton, Christina C, Song, Mingyang, Papadimitriou, Nikos, Hoffmeister, Michael, Phipps, Amanda I, Harrison, Tabitha A, Newcomb, Polly A, Aglago, Elom K, Berndt, Sonja I, Brenner, Hermann, Buchanan, Daniel D, Cao, Yin, Chan, Andrew T, Chen, Xuechen, Cheng, Iona, Chang-Claude, Jenny, Dimou, Niki, Drew, David, Farris, Alton B, French, Amy J, Gallinger, Steven, Georgeson, Peter, Giannakis, Marios, Giles, Graham G, Gruber, Stephen B, Harlid, Sophia, Hsu, Li, Huang, Wen-Yi, Jenkins, Mark A, Laskar, Ruhina S, Le Marchand, Loic, Limburg, Paul, Lin, Yi, Mandic, Marko, Nowak, Johnathan A, Obón-Santacana, Mereia, Ogino, Shuji, Qu, Conghui, Sakoda, Lori C, Schoen, Robert E, Southey, Melissa C, Stadler, Zsofia K, Steinfelder, Robert S, Sun, Wei, Thibodeau, Stephen N, Toland, Amanda E, Trinh, Quang M, Tsilidis, Kostas K, Ugai, Tomotaka, Van Guelpen, Bethany, Wang, Xiaoliang, Woods, Michael O, Zaidi, Syed H, Gunter, Marc J, Peters, Ulrike, Campbell, Peter T

“…Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the…”
Get full text

Abstract P3-08-22: The mutational landscape of cancer driver genes in matched primary ductal carcinoma in situ and recurrent ductal carcinoma in situ or recurrent invasive cancers by Bayani, Jane, Trinh, Quang M, Quintayo, Mary Anne, Crozier, Cheryl, Lungu, Ilinca, Dion, Dan, Felipe-Lima, Joema, Pruneri, Giancarlo, Bergh, Jonas, Warnberg, Fredrik, Viale, Giuseppe, Stein, Lincoln D, Bartlett, John MS

“…Due to breast screening, ductal carcinoma in situ (DCIS) accounts for approximately 25% of all newly diagnosed breast neoplasms. Believed to be a precursor to…”
Get full text

Abstract LB090: Associations of somatically mutated genes and pathways with colorectal cancer specific survival in 4,500 colorectal cancer patients by Harrison, Tabitha A., Zaidi, Syed H., Qu, Conghui, Phipps, Amanda I., Steinfelder, Robert S., Trinh, Quang M., Berndt, Sonja I., Buchanan, Daniel D., Campbell, Peter T., Chan, Andrew T., Doheny, Kim F., Drew, David A., Figueiredo, Jane C., Gallinger, Steven J., Giannakis, Marios, Gsur, Andrea, Gunter, Marc J., Hoffmeister, Michael, Huang, Wen-Yi, Limburg, Paul J., Moreno, Victor, Newcomb, Polly A., Ogino, Shuji, Prentice, Ross L., Shelford, Tameka, Sun, Wei, Thibodeau, Stephen N., Hsu, Li, Peters, Ulrike

“…Colorectal cancer (CRC) is a heterogenous disease that develops through somatic mutations in driver genes, leading to activation of diverse neoplastic…”
Get full text

Abstract P4-10-03: The genomic landscape of male breast cancers using the oncomine comprehensive assay for actionable mutations by Bayani, Jane, Poncet, Coralie, Crozier, Cheryl, Trinh, Quang M, Hopkins, Megan, Uwimana, Aime Lambert, Piper, Tammy, Cunningham, Carrie, Sobol, Monika, Aebi, Stefan, Benstead, Kim, Bogler, Oliver, Lago, Lissandra Dal, Hilbers, Florentine, Hedenfalk, Ingrid, Korde, Larissa, Linderholm, Barbro, Martens, John, Middleton, Lavinia, Murray, Melissa, Kelly, Catherine, Nilsson, Cecilia, Nowaczyk, Monika, Peeters, Stephanie, Peric, Aleksandra, Porter, Peggy, Schröder, Carolien, Rubio, Isabel T, Ruddy, Kathryn J, van Asperen, Christi, Weyngaert, Danielle Van Den, van Deurzen, Carolien HM, van Leeuwen-Stok, Elise, Vermeij, Joanna, Winer, Eric, Stein, Lincoln D, Giordano, Sharon H, Cardoso, Fatima, Bartlett, John MS

“…Introduction: Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers (BC) and 1% of all cancers in males. The clinical…”
Get full text

Copy-number and targeted sequencing analyses to identify distinct prognostic groups: Implications for patient selection to targeted therapies amongst anti-endocrine therapy resistant early breast cancers by Bayani, Jane, Kornaga, Elizabeth, Crozier, Cheryl, Jang, Gun Ho, Kalatskaya, Irina, Trinh, Quang M, Yao, Cindy Q, Livingstone, Julie, Hasenburg, Annette, Kieback, Dirk G, Markopoulos, Christos, Dirix, Luc, Boutros, Paul Christopher, Spears, Melanie, Stein, Lincoln D., Rea, Daniel, Bartlett, John

“…Abstract only 524 Background: Hormone receptor positive breast cancer is a therapeutic challenge. Despite optimal anti-endocrine therapies, most breast cancer…”
Get full text