Search Results - "Trinh, Diane L"

Analysis of FOXO1 mutations in diffuse large B-cell lymphoma by Trinh, Diane L., Scott, David W., Morin, Ryan D., Mendez-Lago, Maria, An, Jianghong, Jones, Steven J.M., Mungall, Andrew J., Zhao, Yongjun, Schein, Jacqueline, Steidl, Christian, Connors, Joseph M., Gascoyne, Randy D., Marra, Marco A.

“…Diffuse large B-cell lymphoma (DLBCL) accounts for 30% to 40% of newly diagnosed lymphomas and has an overall cure rate of approximately 60%. Previously, we…”
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A Scalable Strand-Specific Protocol Enabling Full-Length Total RNA Sequencing From Single Cells by Haile, Simon, Corbett, Richard D., LeBlanc, Veronique G., Wei, Lisa, Pleasance, Stephen, Bilobram, Steve, Nip, Ka Ming, Brown, Kirstin, Trinh, Eva, Smith, Jillian, Trinh, Diane L., Bala, Miruna, Chuah, Eric, Coope, Robin J. N., Moore, Richard A., Mungall, Andrew J., Mungall, Karen L., Zhao, Yongjun, Hirst, Martin, Aparicio, Samuel, Birol, Inanc, Jones, Steven J. M., Marra, Marco A.

“…RNA sequencing (RNAseq) has been widely used to generate bulk gene expression measurements collected from pools of cells. Only relatively recently have…”
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Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity by LeBlanc, Véronique G., Trinh, Diane L., Aslanpour, Shaghayegh, Hughes, Martha, Livingstone, Dorothea, Jin, Dan, Ahn, Bo Young, Blough, Michael D., Cairncross, J. Gregory, Chan, Jennifer A., Kelly, John J.P., Marra, Marco A.

“…Glioblastomas (GBMs) are aggressive brain tumors characterized by extensive inter- and intratumor heterogeneity. Patient-derived models, such as organoids and…”
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Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing by Morin, Ryan D., Mungall, Karen, Pleasance, Erin, Mungall, Andrew J., Goya, Rodrigo, Huff, Ryan D., Scott, David W., Ding, Jiarui, Roth, Andrew, Chiu, Readman, Corbett, Richard D., Chan, Fong Chun, Mendez-Lago, Maria, Trinh, Diane L., Bolger-Munro, Madison, Taylor, Greg, Hadj Khodabakhshi, Alireza, Ben-Neriah, Susana, Pon, Julia, Meissner, Barbara, Woolcock, Bruce, Farnoud, Noushin, Rogic, Sanja, Lim, Emilia L., Johnson, Nathalie A., Shah, Sohrab, Jones, Steven, Steidl, Christian, Holt, Robert, Birol, Inanc, Moore, Richard, Connors, Joseph M., Gascoyne, Randy D., Marra, Marco A.

“…Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of at least 2 molecular subtypes that differ in gene expression and…”
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MicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia by Lim, Emilia L, Trinh, Diane L, Ries, Rhonda E, Wang, Jim, Gerbing, Robert B, Ma, Yussanne, Topham, James, Hughes, Maya, Pleasance, Erin, Mungall, Andrew J, Moore, Richard, Zhao, Yongjun, Aplenc, Richard, Sung, Lillian, Kolb, E Anders, Gamis, Alan, Smith, Malcolm, Gerhard, Daniela S, Alonzo, Todd A, Meshinchi, Soheil, Marra, Marco A

“…Purpose Children with acute myeloid leukemia (AML) whose disease is refractory to standard induction chemotherapy therapy or who experience relapse after…”
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Multi-Omic Analysis of CIC's Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity by Takemon, Yuka, LeBlanc, Véronique G, Song, Jungeun, Chan, Susanna Y, Lee, Stephen Dongsoo, Trinh, Diane L, Ahmad, Shiekh Tanveer, Brothers, William R, Corbett, Richard D, Gagliardi, Alessia, Moradian, Annie, Cairncross, J Gregory, Yip, Stephen, Aparicio, Samuel A J R, Chan, Jennifer A, Hughes, Christopher S, Morin, Gregg B, Gorski, Sharon M, Chittaranjan, Suganthi, Marra, Marco A

“…encodes a transcriptional repressor and MAPK signalling effector that is inactivated by loss-of-function mutations in several cancer types, consistent with a…”
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Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients by Lim, Emilia L, Trinh, Diane L, Scott, David W, Chu, Andy, Krzywinski, Martin, Zhao, Yongjun, Robertson, A Gordon, Mungall, Andrew J, Schein, Jacqueline, Boyle, Merrill, Mottok, Anja, Ennishi, Daisuke, Johnson, Nathalie A, Steidl, Christian, Connors, Joseph M, Morin, Ryan D, Gascoyne, Randy D, Marra, Marco A

“…Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30% to 40% of patients failing to be cured with available primary therapy. microRNAs…”
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Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis by Trinh, Diane L N, Elwi, Adam N, Kim, Sung-Woo

“…The p53 tumor suppressor induces apoptosis in response to genotoxic and environmental stresses. Separately from its functions as a transcription factor, it is…”
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Genetic screen identifies insulin-like growth factor binding protein 5 as a modulator of tamoxifen resistance in breast cancer by Ahn, Bo Young, Elwi, Adam N, Lee, Byoungchun, Trinh, Diane L N, Klimowicz, Alexander C, Yau, Annie, Chan, Jennifer A, Magliocco, Anthony, Kim, Sung-Woo

“…Tamoxifen resistance is one of the overarching challenges in the treatment of patients with estrogen receptor (ER)-positive breast cancer. Through a…”
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A Longitudinal Single-Cell Atlas of Treatment Response in Pediatric AML by Lambo, Sander, Trinh, Diane L., Ries, Rhonda E, Jin, Dan, Setiadi, Audi, Ng, Michelle, Leblanc, Veronique G., Vercauteren, Suzanne, Meshinchi, Soheil, Marra, Marco

“…Introduction: Pediatric acute myeloid leukemia (pAML) is a heterogeneous disease in terms of driver alterations, treatment response and patient outcomes…”
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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma by Morin, Ryan D., Mendez-Lago, Maria, Mungall, Andrew J., Goya, Rodrigo, Mungall, Karen L., Corbett, Richard D., Johnson, Nathalie A., Severson, Tesa M., Chiu, Readman, Field, Matthew, Jackman, Shaun, Krzywinski, Martin, Scott, David W., Trinh, Diane L., Tamura-Wells, Jessica, Li, Sa, Firme, Marlo R., Rogic, Sanja, Griffith, Malachi, Chan, Susanna, Yakovenko, Oleksandr, Meyer, Irmtraud M., Zhao, Eric Y., Smailus, Duane, Moksa, Michelle, Chittaranjan, Suganthi, Rimsza, Lisa, Brooks-Wilson, Angela, Spinelli, John J., Ben-Neriah, Susana, Meissner, Barbara, Woolcock, Bruce, Boyle, Merrill, McDonald, Helen, Tam, Angela, Zhao, Yongjun, Delaney, Allen, Zeng, Thomas, Tse, Kane, Butterfield, Yaron, Birol, Inanç, Holt, Rob, Schein, Jacqueline, Horsman, Douglas E., Moore, Richard, Jones, Steven J. M., Connors, Joseph M., Hirst, Martin, Gascoyne, Randy D., Marra, Marco A.

“…Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched…”
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A microRNA Expression-Based Model Predicts Event Free Survival in Pediatric Acute Myeloid Leukemia by Lim, Emilia L., Trinh, Diane L., Ries, Rhonda E., Wang, Jim, Ma, Yussanne, Topham, James, Hughes, Maya D., Pleasance, Erin, Mungall, Andrew J., Moore, Richard, Zhao, Yongjun, Kolb, E. Anders, Gamis, Alan S., Gerhard, Daniela S., Alonzo, Todd A., Meshinchi, Soheil, Marra, Marco A.

“…INTRODUCTION Acute myeloid leukemia (AML) is a hematopoietic malignancy that comprises almost 25% of pediatricleukemiasand is characterized by genetic and…”
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Comprehensive Sequence Analysis of Relapse and Refractory Pediatric Acute Myeloid Leukemia Identifies miRNA and mRNA Transcripts Associated with Treatment Resistance - a Report from the COG/NCI-Target AML Initiative by Lim, Emilia L., Trinh, Diane L., Ries, Rhonda E., Ma, Yussanne, Topham, James, Hughes, Maya D., Pleasance, Erin, Mungall, Andrew J., Moore, Richard, Zhao, Yongjun, Gerhard, Daniela S., Oehler, Vivian, Kolb, E. Anders, Gamis, Alan S., Smith, Malcolm A., Alonzo, Todd A., Arceci, Robert J., Meshinchi, Soheil, Marra, Marco A.

“…Introduction Induction chemotherapy results in complete remission in 80% of children with acute myeloid leukemia (AML). However, many patients either fail to…”
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