Search Results - "Trinh, Chi H"

Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance by Stevenson, Sean R., Kamisugi, Yasuko, Trinh, Chi H., Schmutz, Jeremy, Jenkins, Jerry W., Grimwood, Jane, Muchero, Wellington, Tuskan, Gerald A., Rensing, Stefan A., Lang, Daniel, Reski, Ralf, Melkonian, Michael, Rothfels, Carl J., Li, Fay-Wei, Larsson, Anders, Wong, Gane K.-S., Edwards, Thomas A., Cuming, Andrew C.

“…The anatomically simple plants that first colonized land must have acquired molecular and biochemical adaptations to drought stress. Abscisic acid (ABA)…”
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Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation by Haywood, Natalie J, Wolny, Marcin, Rogers, Brendan, Trinh, Chi H, Shuping, Yu, Edwards, Thomas A, Peckham, Michelle

“…α-Actinin-2 (ACTN2) is the only muscle isoform of α-actinin expressed in cardiac muscle. Mutations in this protein have been implicated in mild to moderate…”
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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site by Haza, Katarzyna Z., Martin, Heather L., Rao, Ajinkya, Turner, Amy L., Saunders, Sophie E., Petersen, Britta, Tiede, Christian, Tipping, Kevin, Tang, Anna A., Ajayi, Modupe, Taylor, Thomas, Harvey, Maia, Fishwick, Keri M., Adams, Thomas L., Gaule, Thembaninkosi G., Trinh, Chi H., Johnson, Matthew, Breeze, Alexander L., Edwards, Thomas A., McPherson, Michael J., Tomlinson, Darren C.

“…RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of…”
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Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology by Hughes, David J, Tiede, Christian, Penswick, Natalie, Tang, Anna Ah-San, Trinh, Chi H, Mandal, Upasana, Zajac, Katarzyna Z, Gaule, Thembaninskosi, Howell, Gareth, Edwards, Thomas A, Duan, Jianxin, Feyfant, Eric, McPherson, Michael J, Tomlinson, Darren C, Whitehouse, Adrian

“…Because protein-protein interactions underpin most biological processes, developing tools that target them to understand their function or to inform the…”
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Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli by Gaule, Thembaninkosi G, Smith, Mark A, Tych, Katarzyna M, Pirrat, Pascale, Trinh, Chi H, Pearson, Arwen R, Knowles, Peter F, McPherson, Michael J

“…Copper amine oxidases (CuAOs) are metalloenzymes that reduce molecular oxygen to hydrogen peroxide during catalytic turnover of primary amines. In addition to…”
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Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition by Martin, Heather L., Turner, Amy L., Higgins, Julie, Tang, Anna A., Tiede, Christian, Taylor, Thomas, Siripanthong, Sitthinon, Adams, Thomas L., Manfield, Iain W., Bell, Sandra M., Morrison, Ewan E., Bond, Jacquelyn, Trinh, Chi H., Hurst, Carolyn D., Knowles, Margaret A., Bayliss, Richard W., Tomlinson, Darren C.

“…Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to…”
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The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex by Selvaraj, Muniyandi, Yegambaram, Kavestri, Todd, Eleanor J A A, Richard, Charles-Adrien, Dods, Rachel L, Pangratiou, Georgia M, Trinh, Chi H, Moul, Sophie L, Murphy, James C, Mankouri, Jamel, Éléouët, Jean-François, Barr, John N, Edwards, Thomas A

“…Human respiratory syncytial virus (HRSV) is a negative-stranded RNA virus that causes a globally prevalent respiratory infection, which can cause…”
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Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation by Tanner, Sian J., Ariza, Antonio, Richard, Charles-Adrien, Kyle, Hannah F., Dods, Rachel L., Blondot, Marie-Lise, Wu, Weining, Trincão, José, Trinh, Chi H., Hiscox, Julian A., Carroll, Miles W., Silman, Nigel J., Eléouët, Jean-François, Edwards, Thomas A., Barr, John N.

“…The M2-1 protein of the important pathogen human respiratory syncytial virus is a zinc-binding transcription antiterminator that is essential for viral gene…”
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Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests by Álvarez-Rodríguez, Beatriz, Tiede, Christian, Hoste, Alexis C R, Surtees, Rebecca A, Trinh, Chi H, Slack, Gillian S, Chamberlain, John, Hewson, Roger, Fresco, Alba, Sastre, Patricia, Tomlinson, Darren C, Millner, Paul A, Edwards, Thomas A, Barr, John N

“…Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in…”
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The crystal structure of the Hazara virus nucleocapsid protein by Surtees, Rebecca, Ariza, Antonio, Punch, Emma K, Trinh, Chi H, Dowall, Stuart D, Hewson, Roger, Hiscox, Julian A, Barr, John N, Edwards, Thomas A

“…Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo…”
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Reaction Mechanism of N‑Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis by Daniels, Adam D, Campeotto, Ivan, van der Kamp, Marc W, Bolt, Amanda H, Trinh, Chi H, Phillips, Simon E. V, Pearson, Arwen R, Nelson, Adam, Mulholland, Adrian J, Berry, Alan

“…N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield…”
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Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase by Drulyte, Ieva, Obajdin, Jana, Trinh, Chi H, Kalverda, Arnout P, van der Kamp, Marc W, Hemsworth, Glyn R, Berry, Alan

“…Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of 'tailoring' steps to form the…”
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Crystal Structure of Monomeric Human β-2-Microglobulin Reveals Clues to Its Amyloidogenic Properties by Trinh, Chi H., Smith, David P., Kalverda, Arnout P., Simon E. V. Phillips, Radford, Sheena E.

“…Dissociation of human β-2-microglobulin (β2m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from…”
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Structures of alternatively spliced isoforms of human ketohexokinase by Trinh, Chi H., Asipu, Aruna, Bonthron, David T., Phillips, Simon E. V.

“…A molecular understanding of the unique aspects of dietary fructose metabolism may be the key to understanding and controlling the current epidemic of…”
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Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase by Smith, Mark A, Pirrat, Pascale, Pearson, Arwen R, Kurtis, Christian R. P, Trinh, Chi H, Gaule, Thembaninkosi G, Knowles, Peter F, Phillips, Simon E. V, McPherson, Michael J

“…To investigate the role of the active site copper in Escherichia coli copper amine oxidase (ECAO), we initiated a metal-substitution study. Copper…”
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Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein by Bingham, Richard J., Findlay, John B. C., Hsieh, Shih-Yang, Kalverda, Arnout P., Kjellberg, Alexandra, Perazzolo, Chiara, Phillips, Simon E. V., Seshadri, Kothandaraman, Trinh, Chi H., Turnbull, W. Bruce, Bodenhausen, Geoffrey, Homans, Steve W.

“…In the present study we examine the thermodynamics of binding of two related pyrazine-derived ligands to the major urinary protein, MUP-I, using a combination…”
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Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study by Srdanović, Sonja, Wolter, Madita, Trinh, Chi H., Ottmann, Christian, Warriner, Stuart L., Wilson, Andrew J.

“…p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis and senescence. The p53 pathway has therefore…”
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X-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution by Kleinschroth, Thomas, Castellani, Michela, Trinh, Chi H., Morgner, Nina, Brutschy, Bernhard, Ludwig, Bernd, Hunte, Carola

“…The respiratory cytochrome bc1 complex is a fundamental enzyme in biological energy conversion. It couples electron transfer from ubiquinol to cytochrome c…”
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Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5 by Vella, Marita, Manfield, Iain W., Seychell, Brandon C., Trinh, Chi H., Rambo, Robert, Nasir Khan, G., Vassallo, Josanne, Hunter, Thérèse, Hunter, Gary J.

“…The aryl hydrocarbon receptor interacting protein (AIP) is a cytoplasmic molecular co-chaperone and tumour suppressor that assists in protein stability and…”
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Molecular analysis of sixteen unrelated factor XIIIA deficient families from south‐east of Iran by Trinh, Chi H., Sh ElSayed, Walid, Eshghi, Peyman, Miri‐Moghaddam, Ebrahim, Zadeh‐Vakili, Azita, Markham, Alexander F., Anwar, Rashida

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