Higher all-cause hospitalization among patients with chronic hepatitis C: the Chronic Hepatitis Cohort Study (CHeCS), 2006-2013

Summary In the United States, hospitalization among patients with chronic hepatitis C virus (HCV) infection is high. The healthcare burden associated with hospitalization is not clearly known. We analysed data from the Chronic Hepatitis Cohort Study, an observational cohort of patients receiving car...

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Bibliographic Details
Published in:	Journal of viral hepatitis Vol. 23; no. 10; pp. 748 - 754
Main Authors:	Teshale, E. H., Xing, J., Moorman, A., Holmberg, S. D., Spradling, P. R., Gordon, S. C., Rupp, L. B., Lu, M., Boscarino, J. A., Trinacity, C.M., Schmidt, M. A., Xu, F.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-10-2016 Wiley Subscription Services, Inc
Subjects:	Adolescent Adult Aged Aged, 80 and over all-cause hospitalization chronic HCV infection Family income Female health burden Hepatitis hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - epidemiology Hospitalization hospitalization rate Humans Incidence Infections liver-related hospitalization Male Middle Aged Risk Assessment United States - epidemiology Young Adult hospitalization rate liver-related hospitalization chronic HCV infection health burden all-cause hospitalization hepatitis C
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Summary:	Summary In the United States, hospitalization among patients with chronic hepatitis C virus (HCV) infection is high. The healthcare burden associated with hospitalization is not clearly known. We analysed data from the Chronic Hepatitis Cohort Study, an observational cohort of patients receiving care at four integrated healthcare systems, collected from 2006 to 2013 to determine all‐cause hospitalization rates of patients with chronic HCV infection and the other health system patients. To compare the hospitalization rates, we selected two health system patients for each chronic HCV patient using their propensity score (PS). Propensity score matching was conducted by site, gender, race, age and household income to minimize differences attributable to these characteristics. We also compared primary reason for hospitalization between chronic HCV patients and the other health system patients. Overall, 10 131 patients with chronic HCV infection and 20 262 health system patients were selected from the 1 867 802 health system patients and were matched by PS. All‐cause hospitalization rates were 27.4 (27.0–27.8) and 7.4 (7.2–7.5) per 100 persons‐year (PY) for chronic HCV patients and for the other health system patients, respectively. Compared to health system patients, hospitalization rates were significantly higher by site, gender, age group, race and household income among chronic HCV patients (P < 0.001). Compared to health system patients, chronic HCV patients were more likely to be hospitalized from liver‐related conditions (RR = 24.8, P < 0.001). Hence, patients with chronic HCV infection had approximately 3.7‐fold higher all‐cause hospitalization rate than other health system patients. These findings highlight the incremental costs and healthcare burden of patients with chronic HCV infection associated with hospitalization.
Bibliography:	Vertex Pharmaceuticals Bristol-Myers Squibb Genentech istex:4BD2D14F70A480918ED55EABCF599DE0FF8050AD CDC Foundation Janssen Pharmaceuticals, Inc Roche Group AbbVie ark:/67375/WNG-41Q39SNT-R ArticleID:JVH12548 Gilead Sciences ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1352-0504 1365-2893
DOI:	10.1111/jvh.12548