Search Results - "Trimble, E. R."

Insulin-requiring diabetes in rural Ethiopia: should we reopen the case for malnutrition-related diabetes by Alemu, S, Dessie, A, Seid, E, Bard, E, Lee, P. T, Trimble, E. R, Phillips, D. I. W, Parry, E. H. O

“…Aims/hypothesis We evaluated the incidence of insulin-requiring diabetes in a rural area of sub-Saharan Africa. Methods Health surveillance data from a chronic…”
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Insulin-requiring diabetes in Ethiopia: associations with poverty, early undernutrition and anthropometric disproportion by Fekadu, S, Yigzaw, M, Alemu, S, Dessie, A, Fieldhouse, H, Girma, T, Trimble, E.R, Phillips, D.I.W, Parry, E.H.O

“…Background/Objectives: Most insulin-requiring diabetes patients in Ethiopia have an atypical form of the disease, which resembles previous descriptions of…”
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Tyrosinemia type II: Mutation update, 11 novel mutations and description of 5 independent subjects with a novel founder mutation by Peña‐Quintana, L., Scherer, G., Curbelo‐Estévez, M.L., Jiménez‐Acosta, F., Hartmann, B., La Roche, F., Meavilla‐Olivas, S., Pérez‐Cerdá, C., García‐Segarra, N., Giguère, Y., Huppke, P., Mitchell, G.A., Mönch, E., Trump, D., Vianey‐Saban, C., Trimble, E.R., Vitoria‐Miñana, I., Reyes‐Suárez, D., Ramírez‐Lorenzo, T., Tugores, A.

“…Background Tyrosinemia type II, also known as Richner‐Hanhart Syndrome, is an extremely rare autosomal recessive disorder, caused by mutations in the gene…”
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Glucose lowers the threshold for human aortic vascular smooth muscle cell migration: inhibition by protein phosphatase-2A by Campbell, M, Anderson, P, Trimble, E. R

“…Aims/hypothesis Atherosclerosis, which occurs prematurely in individuals with diabetes, incorporates vascular smooth muscle cell (VSMC) chemotaxis. Glucose,…”
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Measurement of malondialdehyde in plasma by high performance liquid chromatography with fluorimetric detection by Young, I S, Trimble, E R

“…The thiobarbituric acid test for malondialdehyde is widely used as an indicator of lipid peroxidation and free radical activity. We describe a simple and…”
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Glucose-induced oxidative stress in vascular contractile cells: comparison of aortic smooth muscle cells and retinal pericytes by SHARPE, P. C, LIU, W.-H, YUE, K. K. M, MCMASTER, D, CATHERWOOD, M. A, MCGINTY, A. M, TRIMBLE, E. R

“…Glucose-induced oxidative stress in vascular contractile cells: comparison of aortic smooth muscle cells and retinal pericytes. P C Sharpe , W H Liu , K K Yue…”
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Diabetes-induced activation of protein kinase C inhibits store-operated Ca2+ uptake in rat retinal microvascular smooth muscle by CURTIS, T. M, MAJOR, E. H, TRIMBLE, E. R, SCHOLFIELD, C. N

“…To assess the effects of diabetes-induced activation of protein kinase C (PKC) on voltage-dependent and voltage-independent Ca2+ influx pathways in retinal…”
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Very low density lipoprotein subfractions in Type II diabetes mellitus: alterations in composition and susceptibility to oxidation by MCENENY, J, O'KANE, M. J, MOLES, K. W, MCMASTER, C, MCMASTER, D, MERCER, C, TRIMBLE, E. R, YOUNG, I. S

“…Type II (non-insulin-dependent) diabetes mellitus is associated with raised triglycerides and increased very low density lipoprotein cholesterol. The aim of…”
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Interaction of glucose and long chain fatty acids (C18) on antioxidant defences and free radical damage in porcine vascular smooth muscle cells in vitro by HAMILTON, J. S, POWELL, L. A, MCMASTER, C, MCMASTER, D, TRIMBLE, E. R

“…Abnormalities of glucose and fatty acid metabolism in diabetes are believed to contribute to the development of oxidative stress and the long term vascular…”
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The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells by SHARPE, P. C, YUE, K. K. M, CATHERWOOD, M. A, MCMASTER, D, TRIMBLE, E. R

“…Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the…”
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Fenofibrate and pioglitazone improve endothelial function and reduce arterial stiffness in obese glucose tolerant men by Ryan, Kathryn E, McCance, D.R, Powell, L, McMahon, R, Trimble, E.R

“…Abstract Obesity is a low grade inflammatory state associated with premature cardiovascular morbidity and mortality. Along with traditional risk factors the…”
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Follow up of fetal outcome in cases of maternal phenylketonuria in Northern Ireland by Magee, A C, Ryan, K, Moore, A, Trimble, E R

“…Background: Maternal phenylketonuria (PKU) can result in multiple congenital anomalies. In Northern Ireland, the prevalence of PKU is relatively high at 1 in…”
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L-carnitine in cyclical vomiting syndrome by McLoughlin, L M, Trimble, E R, Jackson, P, Chong, S K F

“…None were effective, although sedation with lorazepam during exacerbations reduced the length of hospitalisation. Since diagnosis, he had been an inpatient on…”
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Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study by Wiggam, M I, O'Kane, M J, Harper, R, Atkinson, A B, Hadden, D R, Trimble, E R, Bell, P M

“…Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized…”
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Acute respiratory distress syndrome in long‐chain 3‐hydroxyacyl‐CoA dehydrogenase and mitochondrial trifunctional protein deficiencies by Lundy, C. T., Shield, J. P. H., Kvittingen, E. A., Vinorum, O. J., Trimble, E. R., Morris, A. A. M.

“…Inborn errors of metabolism have not previously been recognized as a risk factor for acute respiratory distress syndrome (ARDS). We report this complication in…”
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Exercise responses in patients with IDDM by Nugent, A.M. (Regional Medical Cardiology Centre, Northern Ireland, UK.), Steele, I.C, Al-Modaris, F, Vallely, S, Moore, A, Campbell, N.P.S, Bell, P.M, Buchanan, K.D, Trimble, E.R, Nicholls, D.P

“…Exercise responses in patients with IDDM. A M Nugent , I C Steele , F al-Modaris , S Vallely , A Moore , N P Campbell , P M Bell , K D Buchanan , E R Trimble…”
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Lipid peroxidation and antioxidant status following thrombolytic therapy for acute myocardial infarction by Young, I S, Purvis, J A, Lightbody, J H, Adgey, A A, Trimble, E R

“…We have investigated the timescale of increased lipid peroxidation following successful early thrombolytic therapy for acute myocardial infarction and report…”
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The effect of endothelin 1 on the retinal microvascular pericyte by Chakravarthy, U, Gardiner, T A, Anderson, P, Archer, D B, Trimble, E R

“…The effect of the highly vasoactive peptide endothelin 1 (ET1) was tested on bovine retinal microvascular pericytes propagated in vitro. Specific binding of…”
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The effect of cortisol on glucose/glucose-6-phosphate cycle activity and insulin action by Rooney, D P, Neely, R D, Cullen, C, Ennis, C N, Sheridan, B, Atkinson, A B, Trimble, E R, Bell, P M

“…Increased glucose/glucose-6-phosphate (G/G6P) substrate cycle activity may be an early marker of disordered hepatic glucose metabolism. To investigate the…”
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Abnormalities of serum apo A1 containing lipoprotein particles in patients with primary biliary cirrhosis by O'Kane, M.J, Lynch, P.L.M, Callender, M.E, Trimble, E.R

“…Patients with primary biliary cirrhosis (PBC) do not appear to have an increased risk of cardiovascular disease despite elevations in serum cholesterol. Recent…”
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