Search Results - "Trigun, Surendra Kumar"

Activation of oxidative stress and inflammatory factors could account for histopathological progression of aflatoxin-B1 induced hepatocarcinogenesis in rat by Singh, Krishna Beer, Maurya, Brajesh Kumar, Trigun, Surendra Kumar

“…Aflatoxin-B1 (AFB1) intoxication is known to develop hepatocellular carcinoma (HCC). However, pathogenesis and diagnosis of AFB1-induced HCC remain undefined…”
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Design, Synthesis, and Biological Evaluation of Piperazine and N‑Benzylpiperidine Hybrids of 5‑Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer’s Disease Therapy by Waiker, Digambar Kumar, Verma, Akash, Akhilesh, A, Gajendra T., Singh, Namrata, Roy, Anima, Dilnashin, Hagera, Tiwari, Vinod, Trigun, Surendra Kumar, Singh, Surya P., Krishnamurthy, Sairam, Lama, Prem, Davisson, Vincent Jo, Shrivastava, Sushant Kumar

“…Our present work demonstrates the successful design and synthesis of a new class of compounds based upon a multitargeted directed ligand design approach to…”
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Impairments of Spatial Memory and N-methyl-d-aspartate Receptors and Their Postsynaptic Signaling Molecules in the Hippocampus of Developing Rats Induced by As, Pb, and Mn Mixture Exposure by Chandravanshi, Lalit P, Agrawal, Prashant, Darwish, Hany W, Trigun, Surendra Kumar

“…Exposure to metal mixtures is recognized as a real-life scenario, needing novel studies that can assess their complex effects on brain development. There is…”
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Oral Release Kinetics, Biodistribution, and Excretion of Dopants from Barium-Containing Bioactive Glass in Rats by Majumdar, Shreyasi, Tiwari, Anshul, Mallick, Debasmit, Patel, Devendra K., Trigun, Surendra Kumar, Krishnamurthy, Sairam

“…Background: Inorganic biomaterials are biologically active and are used as implants and drug delivery system. They have therapeutically active elements present…”
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Selective Cu2+ Ion Sensing by Nanoaggregates of Pyridyl‐2,6‐bis(3‐allylsalicylaldehyde)hydrazone by Rai, Abhishek, Tripathi, Kamini, Kumar Sonkar, Avinash, James, Tony D., Yashaswee, Saurabh, Kumar Trigun, Surendra, Mishra, Lallan

“…Pyridyl‐2,6‐bis(3‐allylsalicylaldehyde) hydrazone (PYAL) forms nanoaggregates (nPYAL) in THF:water (10:90,v/v) with enhanced emission. The nanoagregates…”
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Cationic Ru(II), Rh(III) and Ir(III) complexes containing cyclic -perimeter and 2-aminophenyl benzimidazole ligands: Synthesis, molecular structure, DNA and protein binding, cytotoxicity and anticancer activity by Kumar, Amit, Kumar, Ashish, Gupta, Rakesh Kumar, Paitandi, Rajendra Prasad, Singh, Krishna Beer, Trigun, Surendra Kumar, Hundal, Maninder Singh, Pandey, Daya Shankar

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Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase by Koiri, Raj Kumar, Trigun, Surendra Kumar, Dubey, Santosh Kumar, Singh, Santosh, Mishra, Lallan

“…Metal complex-protein interaction is an evolving concept for determining cellular targets of metallodrugs. Lacatate dehydrogenase (LDH) is critically…”
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Fisetin induces apoptosis in colorectal cancer cells by suppressing autophagy and down-regulating nuclear factor erythroid 2-related factor 2 (Nrf2) by Pandey, Akanksha, Trigun, Surendra Kumar

“…Modulation of autophagy is evolving as a relevant strategy in cancer pathogenesis and therapeutic intervention and hence, needs to be examined as a target for…”
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Cilostamide, a phosphodiesterase 3A inhibitor, sustains meiotic arrest of rat oocytes by modulating cyclic adenosine monophosphate level and the key regulators of maturation promoting factor by Gupta, Anumegha, Trigun, Surendra Kumar

“…Cilostamide, a phosphodiesterase 3A (Pde3A) inhibitor, is known to increase intraoocyte cyclic adenosine monophosphate (cAMP) level which is involved in…”
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The restoration of hippocampal nerve de‐myelination by methylcobalamin relates with the enzymatic regulation of homocysteine level in a rat model of moderate grade hepatic encephalopathy by Roy, Anima, Trigun, Surendra Kumar

“…This article describes how methylcobalamin (MeCbl) restores nerve myelination in a moderate‐ grade hepatic encephalopathy (MoHE) model of ammonia…”
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Mapping Connectome in Mammalian Brain: A Novel Approach by Bioengineering Neuro-Glia specific Vectors by Ganguly, Krishnendu, Trigun, Surendra Kumar

“…•We propose to label the Mammalian Connectome by using novel Neuro-Glia specific Vectors and Transcriptional/ Translational Messengers.•In vitro transfected…”
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Mitochondrial SIRT3 and neurodegenerative brain disorders by Anamika, Khanna, Archita, Acharjee, Papia, Acharjee, Arup, Trigun, Surendra Kumar

“…•Sirtuins deacetylate an array of proteins to execute cell survival strategies.•Mitochondrial derangement is the central event of neuro-excitotoxic brain…”
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Restoration of hippocampal adult neurogenesis by CDRI‐08 (Bacopa monnieri extract) relates with the recovery of BDNF–TrkB levels in male rats with moderate grade hepatic encephalopathy by Mallick, Debasmit, Acharjee, Arup, Acharjee, Papia, Trigun, Surendra Kumar

“…Modulation of in vivo adult neurogenesis (AN) is an evolving concept in managing neurodegenerative diseases. CDRI‐08, a bacoside‐enriched fraction of Bacopa…”
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Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats by Maurya, Brajesh Kumar, Trigun, Surendra Kumar

“…Fisetin, a known antioxidant, has been found to be cytotoxic against certain cell lines. However, the mechanism by which it inhibits tumor growth in vivo…”
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Ambroxol modulates 6-Hydroxydopamine-induced temporal reduction in Glucocerebrosidase (GCase) enzymatic activity and Parkinson’s disease symptoms by Mishra, Akanksha, Chandravanshi, Lalit Pratap, Trigun, Surendra Kumar, Krishnamurthy, Sairam

“…[Display omitted] Reduced glucocerebrosidase (GCase) enzymatic activity is found in sporadic cases of Parkinson’s disease making GCase a serious risk factor…”
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Modulation of brain energy metabolism in hepatic encephalopathy: impact of glucose metabolic dysfunction by Prasad, Shambhu Kumar, Acharjee, Arup, Singh, Vishal Vikram, Trigun, Surendra Kumar, Acharjee, Papia

“…Cerebral function is linked to a high level of metabolic activity and relies on glucose as its primary energy source. Glucose aids in the maintenance of…”
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Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats by Mondal, Papia, Trigun, Surendra Kumar

“…Hepatic encephalopathy (HE), characterized by impaired cerebellar functions during chronic liver failure (CLF), involves N-methyl-D-aspartate receptor (NMDAR)…”
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Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival by Rawat, Divya, Chhonker, Saurabh Kumar, Naik, Rayees Ahmad, Mehrotra, Aditi, Trigun, Surendra Kumar, Koiri, Raj Kumar

“…Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high lactate with acidic pH) in tumor microenvironment. Why tumor…”
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Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices by Mehrotra, Aditi, Trigun, Surendra Kumar

“…Rapid metabolism of lactate is an important aspect of bioenergetic adaptation in the brain during non-physiological conditions. The low grade hyperammonemia…”
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Moderate Grade Hyperammonemia Induced Concordant Activation of Antioxidant Enzymes is Associated with Prevention of Oxidative Stress in the Brain Slices by Mehrotra, Aditi, Trigun, Surendra Kumar

“…Acute hyperammonemia (HA) induced oxidative stress in the brain is considered to play critical roles in the neuropathology of end stage hepatic encephalopathy…”
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