Search Results - "Trievel, R C"

Purification, Biochemical Analysis, and Structure Determination of JmjC Lysine Demethylases by Krishnan, S, Trievel, R C

“…Jumonji C (JmjC) lysine demethylases (KDMs) catalyze the site- and state-specific demethylation of lysine residues in histone and nonhistone protein…”
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Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray by Cornett, E M, Dickson, B M, Vaughan, R M, Krishnan, S, Trievel, R C, Strahl, B D, Rothbart, S B

“…The dynamic addition and removal of covalent posttranslational modifications (PTMs) on histone proteins serves as a major mechanism regulating…”
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A coupled fluorescent assay for histone methyltransferases by Collazo, Evys, Couture, Jean-François, Bulfer, Stacie, Trievel, Raymond C.

“…Histone methyltransferases (HMTs) catalyze the S-adenosylmethionine (AdoMet)-dependent methylation of lysines and arginines in the nucleosomal core histones H3…”
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Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14 by Lo, Wan-Sheng, Trievel, Raymond C, Rojas, Jeannie R, Duggan, Laura, Hsu, Jer-Yuan, Allis, C.David, Marmorstein, Ronen, Berger, Shelley L

“…Multiple covalent modifications exist in the amino-terminal tails of core histones, but whether a relationship exists between them is unknown. We examined the…”
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Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide by Marmorstein, Ronen, Rojas, Jeannie R, Trievel, Raymond C, Zhou, Jianxin, Mo, Yi, Li, Xinmin, Berger, Shelley L, Allis, C. David

“…Gene activation is a highly regulated process that requires the coordinated action of proteins to relieve chromatin repression and to promote transcriptional…”
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Structure and function of histone methyltransferases by Trievel, Raymond C

“…Histones are the major protein constituent of chromatin in the eukaryotic nucleus. These proteins undergo a host of different post-translational modifications,…”
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Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator by Tanner, K G, Trievel, R C, Kuo, M H, Howard, R M, Berger, S L, Allis, C D, Marmorstein, R, Denu, J M

“…Within chromatin, reversible acetylation of core histones is critical for transcriptional activation of eukaryotic target genes. The recent identification of…”
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Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A by Clements, Adrienne, Rojas, Jeannie R., Trievel, Raymond C., Wang, Lian, Berger, Shelley L., Marmorstein, Ronen

“…The human p300/CBP‐associating factor, PCAF, mediates transcriptional activation through its ability to acetylate nucleosomal histone substrates as well as…”
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p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage by Liu, Lin, Scolnick, Daniel M., Trievel, Raymond C., Zhang, Hong Bing, Marmorstein, Ronen, Halazonetis, Thanos D., Berger, Shelley L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Application of a Fluorescent Histone Acetyltransferase Assay to Probe the Substrate Specificity of the Human p300/CBP-Associated Factor by Trievel, Raymond C., Li, Feng-Yen, Marmorstein, Ronen

“…Histone N-acetyltransferases (HATs) are a group of enzymes which acetylate specific lysine residues in the N-terminal tails of nucleosomal histones to promote…”
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Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator by Trievel, R.C, Rojas, J.R, Sterner, D.E, Venkataramani, R.N, Wang, L, Zhou, J, Allis, C.D, Berger, S.L, Marmorstein, R

“…The yeast GCN5 (yGCN5) transcriptional co-activator functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Here, we present the…”
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Coexpression of Proteins in Bacteria Using T7-Based Expression Plasmids: Expression of Heteromeric Cell-Cycle and Transcriptional Regulatory Complexes by Johnston, Karen, Clements, Adrienne, Venkataramani, Ravichandran N., Trievel, Raymond C., Marmorstein, Ronen

“…This report describes the development and application of a dual vector coexpression system for the overproduction of heteromeric cell cycle and transcriptional…”
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Role of the Carbonyl Group in Thioester Chain Length Recognition by the Medium Chain Acyl-CoA Dehydrogenase by Trievel, Raymond C, Wang, Rong, Anderson, Vernon E, Thorpe, Colin

“…Medium chain acyl-CoA dehydrogenase from pig kidney catalyzes the oxidation of acyl-CoA thioesters to trans-2-enoyl-CoA derivatives with an optimal chain…”
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Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 by Wu, Shumin, Trievel, Raymond C., Rice, Judd C.

“…Human SFMBT (hSFMBT) is postulated to be a Polycomb (PcG) protein. Similar to other PcG proteins, we found that hSFMBT displays robust transcriptional…”
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Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors by Abshire, Elizabeth T., Hughes, Kelsey L., Diao, Rucheng, Pearce, Sarah, Gopalakrishna, Shreekara, Trievel, Raymond C., Rorbach, Joanna, Freddolino, Peter L., Goldstrohm, Aaron C.

“…Nocturnin (NOCT) is a eukaryotic enzyme that belongs to a superfamily of exoribonucleases, endonucleases, and phosphatases. In this study, we analyze the…”
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Structural basis for the methylation site specificity of SET7/9 by Trievel, Raymond C, Couture, Jean-François, Collazo, Evys, Hauk, Glenn

“…Human SET7/9 is a protein lysine methyltransferase (PKMT) that methylates histone H3, the tumor suppressor p53 and the TBP-associated factor TAF10. To…”
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Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase by Couture, Jean-François, Collazo, Evys, Brunzelle, Joseph S, Trievel, Raymond C

“…SET8 (also known as PR-SET7) is a histone H4-Lys-20-specific methyltransferase that is implicated in cell-cycle-dependent transcriptional silencing and mitotic…”
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Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase by Trievel, Raymond C., Beach, Bridgette M., Dirk, Lynnette M.A., Houtz, Robert L., Hurley, James H.

“…Protein lysine methylation by SET domain enzymes regulates chromatin structure, gene silencing, transcriptional activation, plant metabolism, and other…”
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The SET-domain protein superfamily: protein lysine methyltransferases by Dillon, Shane C, Zhang, Xing, Trievel, Raymond C, Cheng, Xiaodong

“…The SET-domain protein methyltransferase superfamily includes all but one of the proteins known to methylate histones on lysine. Histone methylation is…”
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Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT by Hurley, James H, Trievel, Raymond C, Flynn, E Megan, Houtz, Robert L

“…SET domain protein methyltransferases catalyze the transfer of methyl groups from the cofactor S-adenosylmethionine (AdoMet) to specific lysine residues of…”
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