Search Results - "Tricoli, Lucas"

Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds by Chou, Szu-Ting, Hom, Kellie, Zhang, Daoning, Leng, Qixin, Tricoli, Lucas J, Hustedt, Jason M, Lee, Amy, Shapiro, Michael J, Seog, Joonil, Kahn, Jason D, Mixson, A. James

“…Abstract Branched peptides containing histidines and lysines (HK) have been shown to be effective carriers for DNA and siRNA. We anticipate that elucidation of…”
Get full text

Surface-Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition by Chou, Szu-Ting, Leng, Qixin, Scaria, Puthupparampil, Kahn, Jason D, Tricoli, Lucas J, Woodle, Martin, Mixson, A. James

“…We characterized in this study the pharmacokinetics and antitumor efficacy of histidine-lysine (HK):siRNA nanoplexes modified with PEG and a cyclic RGD (cRGD)…”
Get full text

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells by Ringer, Lymor, Sirajuddin, Paul, Tricoli, Lucas, Waye, Sarah, Choudhry, Muhammad Umer, Parasido, Erika, Sivakumar, Angiela, Heckler, Mary, Naeem, Aisha, Abdelgawad, Iman, Liu, Xuefeng, Feldman, Adam S, Lee, Richard J, Wu, Chin-Lee, Yenugonda, Venkata, Kallakury, Bhaskar, Dritschilo, Anatoly, Lynch, John, Schlegel, Richard, Rodriguez, Olga, Pestell, Richard G, Avantaggiati, Maria Laura, Albanese, Chris

“…The p53 tumor suppressor protein plays a crucial role in influencing cell fate decisions in response to cellular stress. As p53 elicits cell cycle arrest,…”
Get full text

Direct Observation of Dynamic Mechanical Regulation of DNA Condensation by Environmental Stimuli by Lee, Amy, Karcz, Adam, Akman, Ryan, Zheng, Tai, Kwon, Sara, Chou, Szu-Ting, Sucayan, Sarah, Tricoli, Lucas J., Hustedt, Jason M., Leng, Qixin, Kahn, Jason D., Mixson, A. James, Seog, Joonil

“…Gene delivery is a promising way to treat hereditary diseases and cancer; however, there is little understanding of DNA:carrier complex mechanical properties,…”
Get full text

The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells by Waye, Sarah, Naeem, Aisha, Choudhry, Muhammad Umer, Parasido, Erika, Tricoli, Lucas, Sivakumar, Angiela, Mikhaiel, John P, Yenugonda, Venkata, Rodriguez, Olga C, Karam, Sana D, Rood, Brian R, Avantaggiati, Maria Laura, Albanese, Chris

“…Medulloblastoma (MB), a primitive neuroectodermal tumor, is the most common malignant childhood brain tumor and remains incurable in about a third of patients…”
Get full text

Direct Observation of Dynamic Mechanical Regulation of DNA Condensation by Environmental Stimuli by Lee, Amy, Karcz, Adam, Akman, Ryan, Zheng, Tai, Kwon, Sara, Chou, Szu-Ting, Sucayan, Sarah, Tricoli, Lucas J., Hustedt, Jason M., Leng, Qixin, Kahn, Jason D., Mixson, A. James, Seog, Joonil

“…Gene delivery is a promising way to treat hereditary diseases and cancer; however, there is little understanding of DNA:carrier complex mechanical properties,…”
Get full text

Abstract 2371: MicroRNA-99b-5p targets the mTOR/AR axis and induced autophagic cell death in prostate cancer cells by Niture, Suryakant, Tricoli, Lucas, Hayes, Kala, Kumar, Deepak

“…Abstract MicroRNAs are the small non-coding regulatory RNA molecules involved in a wide array of cellular and molecular processes. MicroRNAs negatively…”
Get full text

Single vs. dual transgene ex vivo gene therapy for multiple sulfatase deficiency by Pham, Vi, Tricoli, Lucas, Wongkittichote, Parith, Hong, Xinying, Schlotawa, Lars, Rivella, Stefano, Ahrens-Nicklas, Rebecca

Get full text

Single vs. dual transgene gene therapy for multiple sulfatase deficiency by Pham, Vi, Tricoli, Lucas, Wongkittichote, Parith, Hong, Xinying, Schlotawa, Lars, Rivella, Stefano, Ahrens-Nicklas, Rebecca

Get full text

Role of microRNAs in the development of hepatocellular carcinoma and acquired drug resistance by Tricoli, Lucas, Niture, Suresh, Chimeh, Uche, Kumar, Deepak

“…Hepatocellular Carcinoma (HCC) is a leading cause of cancer related death worldwide with a relatively poor survival rate. Aside from liver resection and…”
Get full text

Role of microRNAs in the development of hepatocellular carcinoma and drug resistance by Tricoli, Lucas, Niture, Suresh, Chimeh, Uche, Ressom, Habtom, Kumar, Deepak

“…Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide and has a relatively poor survival rate. Aside from liver transplantation,…”
Get full text

Optimizing cross-correction to overcome limitations of ex vivo gene therapy in multiple sulfatase deficiency by Pham, Vi, Tricoli, Lucas, Schlotawa, Lars, Rivella, Stefano, Ahrens-Nicklas, Rebecca

Get full text

Optimizing cross-correction to overcome limitations of gene therapy in multiple sulfatase deficiency by Pham, Vi, Tricoli, Lucas, Schlotawa, Lars, Rivella, Stefano, Ahrens-Nicklas, Rebecca

Get full text

Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer by Choudhary, Saba, Ramasundaram, Poornema, Dziopa, Eugenia, Mannion, Ciaran, Kissin, Yair, Tricoli, Lucas, Albanese, Christopher, Lee, Woo, Zilberberg, Jenny

“…Prostate cancer (PCa) is the second leading cause of cancer deaths among American men. Unfortunately, there is no cure once the tumor is established within the…”
Get full text

MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation by Niture, Suryakant, Tricoli, Lucas, Qi, Qi, Gadi, Sashi, Hayes, Kala, Kumar, Deepak

“…OBJECTIVES: MicroRNAs (miRNAs) are the small non-coding regulatory RNA molecules involved in gene regulation via base-pairing with complementary sequences in…”
Get full text

Improved Gene Therapy for Metachromatic Leukodystrophy by Tricoli, Lucas, Vanderver, Adeline, Adang, Laura, Chappell, Maxwell, Breda, Laura, Tanaka, Naoto, Triebwasser, Michael, Wenger, David, Jarocha, Danuta Jadwiga, Guerra, Amaliris, Schlotawa, Lars, Radhakrishnan, Karthikeyan, Ahrens-Nicklas, Rebecca, Kurre, Peter, Hurwitz, Stephanie, Rivella, Stefano

“…Metachromatic Leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease (LSD) characterized by a decreased Arylsulfatatse A (ARSA) enzymatic…”
Get full text

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation by Tricoli, Lucas, Berry, Deborah L., Albanese, Chris

Get full text

Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient‐derived primary prostate cells by Naeem, Aisha, Dakshanamurthy, Sivanesan, Walthieu, Henry, Parasido, Erika, Avantaggiati, Maria, Tricoli, Lucas, Kumar, Deepak, Lee, Richard J., Feldman, Adam, Noon, Muhammad S., Byers, Stephen, Rodriguez, Olga, Albanese, Chris

“…Background Drug repurposing enables the discovery of potential cancer treatments using publically available data from over 4000 published Food and Drug…”
Get full text

Use of HSC-targeted LNP to generate a mouse model of lethal α-thalassemia and treatment via lentiviral gene therapy by Chappell, Maxwell E., Breda, Laura, Tricoli, Lucas, Guerra, Amaliris, Jarocha, Danuta, Castruccio Castracani, Carlo, Papp, Tyler E., Tanaka, Naoto, Hamilton, Nolan, Triebwasser, Michael P., Ghiaccio, Valentina, Fedorky, Megan T., Gollomp, Kandace L., Bochenek, Veronica, Roche, Aoife M., Everett, John K., Cook, Emma J., Bushman, Frederic D., Teawtrakul, Nattiya, Glentis, Stavros, Kattamis, Antonis, Mui, Barbara L., Tam, Ying K., Weissman, Drew, Abdulmalik, Osheiza, Parhiz, Hamideh, Rivella, Stefano

“…•Deletion of the α-globin genes induces a lethal phenotype associated with high levels of red blood cells in circulation.•Transduction with a lentiviral vector…”
Get full text

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation by Tricoli, Lucas, Berry, Deborah L, Albanese, Chris

“…Conditionally reprogrammed cells (CRCs) provide a sustainable method for primary cell culture and the ability to develop extensive "living biobanks" of patient…”
Get full text