Canakinumab in systemic juvenile idiopathic arthritis: real-world data from a retrospective Italian cohort

Abstract Objective The objective of this study was to use real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with systemic JIA (sJIA). Methods A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and...

Full description

Saved in:

Bibliographic Details
Published in:	Rheumatology (Oxford, England) Vol. 61; no. 4; pp. 1621 - 1629
Main Authors:	De Matteis, Arianna, Bracaglia, Claudia, Pires Marafon, Denise, Piscitelli, Anna Lucia, Alessio, Maria, Naddei, Roberta, Orlando, Francesca, Filocamo, Giovanni, Minoia, Francesca, Ravelli, Angelo, Tibaldi, Jessica, Cimaz, Rolando, Marino, Achille, Simonini, Gabriele, Mastrolia, Maria Vincenza, La Torre, Francesco, Tricarico, Ilaria, Licciardi, Francesco, Montin, Davide, Maggio, Maria Cristina, Alizzi, Clotilde, Martini, Giorgia, Civino, Adele, Gallizzi, Romina, Olivieri, Alma Nunzia, Ardenti Morini, Francesca, Conti, Giovanni, De Benedetti, Fabrizio, Pardeo, Manuela
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 11-04-2022
Subjects:	Antibodies, Monoclonal, Humanized - therapeutic use Arthritis, Juvenile - complications Arthritis, Juvenile - drug therapy Child Glucocorticoids - therapeutic use Humans Macrophage Activation Syndrome - complications Retrospective Studies systemic juvenile idiopathic arthritis clinically inactive disease canakinumab
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Objective The objective of this study was to use real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with systemic JIA (sJIA). Methods A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and adverse events were collected at baseline, and 6 and 12 months after starting canakinumab. The primary outcome measure of effectiveness was clinically inactive disease (CID) off glucocorticoids (GCs) treatment at 6 months. Results A total of 80 children from 15 Italian centres were analysed. Of the 12 patients who started canakinumab in CID while receiving anakinra, all maintained CID. Of the 68 with active disease at baseline, 57.4% achieved CID off GCs at 6 months and 63.8% at 12 months. In univariate analysis, the variables significantly related to non-response were number of active joints (NAJs) ≥5, history of macrophage activation syndrome (MAS) and disease duration. Multivariate analysis confirmed the association between non-response and NAJs ≥5 [odds ratio (OR) 6.37 (95% CI: 1.69, 24.02), P = 0.006] and between non-response and history of MAS [OR 3.53 (95% CI: 1.06, 11.70), P = 0.039]. No serious adverse events were recorded in this series. There were two cases of MAS during canakinumab, leading to a rate of 2.9 episodes per 100 patient years. Conclusion We have confirmed, using real-world data, the efficacy of canakinumab in sJIA in a multicentric cohort. History of MAS and higher NAJ were associated with lower probability of achieving CID.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1462-0324 1462-0332
DOI:	10.1093/rheumatology/keab619