Search Results - "Tribble, James R."

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction by Tribble, James R., Otmani, Amin, Sun, Shanshan, Ellis, Sevannah A., Cimaglia, Gloria, Vohra, Rupali, Jöe, Melissa, Lardner, Emma, Venkataraman, Abinaya P., Domínguez-Vicent, Alberto, Kokkali, Eirini, Rho, Seungsoo, Jóhannesson, Gauti, Burgess, Robert W., Fuerst, Peter G., Brautaset, Rune, Kolko, Miriam, Morgan, James E., Crowston, Jonathan G., Votruba, Marcela, Williams, Pete A.

“…Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in…”
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Sholl analysis: A quantitative comparison of semi-automated methods by Binley, Kate E., Ng, Wai S., Tribble, James R., Song, Bing, Morgan, James E.

“…•We compare four Sholl analysis methods to the manual method.•We validate two Sholl analysis methods.•We highlight two errors in two Sholl analysis methods…”
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Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma by Williams, Pete A, Tribble, James R, Pepper, Keating W, Cross, Stephen D, Morgan, B Paul, Morgan, James E, John, Simon W M, Howell, Gareth R

“…Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function. The…”
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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS by Petrova, Veselina, Pearson, Craig S., Ching, Jared, Tribble, James R., Solano, Andrea G., Yang, Yunfei, Love, Fiona M., Watt, Robert J., Osborne, Andrew, Reid, Evan, Williams, Pete A., Martin, Keith R., Geller, Herbert M., Eva, Richard, Fawcett, James W.

“…Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to…”
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Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production by Tribble, James R., Jöe, Melissa, Varricchio, Carmine, Otmani, Amin, Canovai, Alessio, Habchi, Baninia, Daskalakis, Evangelia, Chaleckis, Romanas, Loreto, Andrea, Gilley, Jonathan, Wheelock, Craig E., Jóhannesson, Gauti, Wong, Raymond C. B., Coleman, Michael P., Brancale, Andrea, Williams, Pete A.

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Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice by Tribble, James R, Harder, Jeffrey M, Williams, Pete A, John, Simon W M

“…Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical…”
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NMNAT2 is a druggable target to drive neuronal NAD production by Tribble, James R., Jöe, Melissa, Varricchio, Carmine, Otmani, Amin, Canovai, Alessio, Habchi, Baninia, Daskalakis, Evangelia, Chaleckis, Romanas, Loreto, Andrea, Gilley, Jonathan, Wheelock, Craig E., Jóhannesson, Gauti, Wong, Raymond C. B., Coleman, Michael P., Brancale, Andrea, Williams, Pete A.

“…Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low…”
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Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients by Rutigliani, Carola, Tribble, James R, Hagström, Anna, Lardner, Emma, Jóhannesson, Gauti, Stålhammar, Gustav, Williams, Pete A

“…Neuroinflammation is recognized as a key component of neurodegenerative disease. In glaucoma, a common neurodegenerative disease and the leading cause of…”
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NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve by Tribble, James R, Hagström, Anna, Jusseaume, Kenza, Lardner, Emma, Wong, Raymond Ching-Bong, Stålhammar, Gustav, Williams, Pete A

“…Glaucoma is the leading cause of irreversible blindness and is a major health and economic burden. Current treatments do not address the neurodegenerative…”
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Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma by Cimaglia, Gloria, Tribble, James R, Votruba, Marcela, Williams, Pete A, Morgan, James E

“…A compromised capacity to maintain NAD pools is recognized as a key underlying pathophysiological feature of neurodegenerative diseases. NAD acts as a…”
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Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume by Otmani, Amin, Jóhannesson, Gauti, Brautaset, Rune, Tribble, James R, Williams, Pete A

“…Leber's hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually…”
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Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma by Tribble, James R, Hui, Flora, Jöe, Melissa, Bell, Katharina, Chrysostomou, Vicki, Crowston, Jonathan G, Williams, Pete A

“…Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of…”
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Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection by Rombaut, Anne, Jovancevic, Danica, Wong, Raymond Ching-Bong, Nicol, Alan, Brautaset, Rune, Finkelstein, David I, Nguyen, Christine T O, Tribble, James R, Williams, Pete A

“…Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and…”
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Glial metabolic alterations during glaucoma pathogenesis by Rombaut, Anne, Brautaset, Rune, Williams, Pete A, Tribble, James R

“…Glaucoma is the leading cause of irreversible blindness. Current treatment options are limited and often only slow disease progression. Metabolic dysfunction…”
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Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection by Canovai, Alessio, Tribble, James R, Jöe, Melissa, Westerlund, Daniela Y, Amato, Rosario, Trounce, Ian A, Dal Monte, Massimo, Williams, Pete A

“…Abstract Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in…”
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Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model by Tribble, James R, Kastanaki, Elizabeth, Uslular, A Berşan, Rutigliani, Carola, Enz, Tim J, Williams, Pete A

“…Neuroinflammation is a critical and targetable pathogenic component of neurodegenerative diseases, including glaucoma, the leading cause of irreversible…”
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Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma by Tribble, James R, Vasalauskaite, Asta, Redmond, Tony, Young, Robert D, Hassan, Shoaib, Fautsch, Michael P, Sengpiel, Frank, Williams, Pete A, Morgan, James E

“…Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. However, the earliest degenerative events that occur in human…”
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Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma by Tribble, James R, Williams, Pete A, Caterson, Bruce, Sengpiel, Frank, Morgan, James E

“…Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision…”
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Microbead models in glaucoma by Morgan, James E., Tribble, James R.

“…The sustained and moderate elevation of intraocular pressure, which can be initiated at precise time points, remains the cornerstone of research into the…”
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Preventing retinal homocysteine dysregulation protects against retinal ganglion cell death by Tribble, James R., Rutigliani, Carola, Canovai, Alessio, Williams, Pete A.

“…Glaucoma, the most common cause of irreversible blindness, is characterized by progressive dysfunction and loss of retinal ganglion cells. There are no…”
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