Relationship of Recurrence Rate with some Characteristics in Patients with Thyroid Carcinoma

Relationship of Recurrence Rate with some Characteristics in Patients with Thyroid Carcinoma

Determining the clinical and subclinical characteristics related to the recurrence status in patients with a thyroid carcinoma has great significance for prognosis, prediction of recurrence and monitoring of treatment outcomes. This study aimed to determine the association between recurrence rate an...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism Vol. 27; no. 6; pp. 544 - 551
Main Authors: Tri, Bui D M, Chi, Bui D P, Hiep, Bui T, Trung, Nguyen H, Minh, Tong D, Dung, Nguyen T N, Bui, Thanh D, Tran, Viet Q, Nguyen, Hiep T
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-11-2023
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects:
braf v600e mutation
Cancer
Carcinoma
Care and treatment
Diseases
lymph node metastasis
Lymphatic system
Medical research
Medicine, Experimental
Metastasis
Mutation
Prognosis
recurrence rate
Relapse
Thyroid cancer
thyroid carcinoma
Thyroid diseases
Vietnam
recurrence rate
thyroid carcinoma
BRAF V600E mutation
lymph node metastasis
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Summary:Determining the clinical and subclinical characteristics related to the recurrence status in patients with a thyroid carcinoma has great significance for prognosis, prediction of recurrence and monitoring of treatment outcomes. This study aimed to determine the association between recurrence rate and some characteristics in patients with thyroid carcinoma. The study was conducted by descriptive method with longitudinal follow-up on 102 thyroid carcinoma patients at 103 Military Hospital, Hanoi, Vietnam, from July 2013 to December 2016. Univariate analysis showed that there was a relationship between the recurrence characteristics in the studied patients and the characteristics of lymph node metastasis ( = 0.026; OR = 15; 95% CI = 1.4-163.2) and BRAF V600E mutation status ( = 0.01; OR = 3.41; 95% CI = 1.31-8.88). When analysing the multivariable Logistic regression model, there was a positive correlation between the occurrence of BRAF V600E gene mutation ( = 0.032; OR = 17.649; 95% CI = 1.290-241.523) and male sex ( = 0.036; OR = 12.788; 95% CI = 1.185-137.961) and the occurrence of recurrence in study patients. The mean time to relapse was earlier in male patients than in female patients ( = 0.02). The mean time to relapse in patients with the BRAF V600E mutation (31.81 ± 1.14 months) was shorter than the mean time to relapse in the group without the mutation (57.82 ± 2.08 months) ( = 0.01). The group of patients with mutations in the BRAF V600E gene increased the risk of recurrence compared with the group without the mutation (HR = 9.14, = 0.04). There is a positive correlation between recurrence and masculinity, lymph node metastasis and the occurrence of BRAF V600E mutations in thyroid carcinoma patients.
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content type line 23
ISSN:2230-8210
2230-9500
DOI:10.4103/ijem.ijem_134_23