Search Results - "Trezise, Derek J."

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy by McCloskey, Conor, Rada, Cara, Bailey, Elizabeth, McCavera, Samantha, van den Berg, Hugo A, Atia, Jolene, Rand, David A, Shmygol, Anatoly, Chan, Yi‐Wah, Quenby, Siobhan, Brosens, Jan J, Vatish, Manu, Zhang, Jie, Denton, Jerod S, Taggart, Michael J, Kettleborough, Catherine, Tickle, David, Jerman, Jeff, Wright, Paul, Dale, Timothy, Kanumilli, Srinivasan, Trezise, Derek J, Thornton, Steve, Brown, Pamela, Catalano, Roberto, Lin, Nan, England, Sarah K, Blanks, Andrew M

“…Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum…”
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Ionworks HT: a new high-throughput electrophysiology measurement platform by Schroeder, Kirk, Neagle, Brad, Trezise, Derek J, Worley, Jennings

“…To address the throughput restrictions of classical patch clamp electrophysiology, Essen Instruments has developed a plate-based electrophysiology measurement…”
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A Functional Role for Small-Conductance Calcium-Activated Potassium Channels in Sensory Pathways Including Nociceptive Processes by Bahia, Parmvir K, Suzuki, Rie, Benton, David C. H, Jowett, Amanda J, Chen, Mao Xiang, Trezise, Derek. J, Dickenson, Anthony H, Moss, Guy W. J

“…We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating…”
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Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment by Hougaard, Charlotte, Jensen, Marianne L, Dale, Tim J, Miller, David D, Davies, David J, Eriksen, Birgitte L, Strøbaek, Dorte, Trezise, Derek J, Christophersen, Palle

“…A new small molecule, 4-(2-methoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X), is presented as an activator of…”
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Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23 by John, Victoria H, Main, Martin J, Powell, Andrew J, Gladwell, Zoe M, Hick, Caroline, Sidhu, Harjeet S, Clare, Jeff J, Tate, Simon, Trezise, Derek J

“…The voltage-gated sodium channel NaV1.8 (SNS, PN3) is thought to be a molecular correlate of the dorsal root ganglion (DRG) tetrodotoxin resistant (TTX-R) Na+…”
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Population patch clamp electrophysiology: a breakthrough technology for ion channel screening by Dale, Tim J, Townsend, Claire, Hollands, Emma C, Trezise, Derek J

“…Population patch clamp (PPC) is a novel high throughput planar array electrophysiology technique that allows ionic currents to be recorded from populations of…”
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Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature by Chen, Mao Xiang, Sandow, Shaun L, Doceul, Virginie, Chen, Yu Hua, Harper, Heather, Hamilton, Bruce, Meadows, Helen J, Trezise, Derek J, Clare, Jeff J

“…HERG potassium channel blockade is the major cause for drug-induced long QT syndrome, which sometimes cause cardiac disrhythmias and sudden death. There is a…”
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Novel 384-well population patch clamp electrophysiology assays for Ca2+-activated K+ channels by John, Victoria H, Dale, Tim J, Hollands, Emma C, Chen, Mao Xiang, Partington, Leanne, Downie, David L, Meadows, Helen J, Trezise, Derek J

“…Planar array electrophysiology techniques were applied to assays for modulators of recombinant hIK and hSK3 Ca2+-activated K+ channels. In CHO-hIK-expressing…”
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Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels by Pier, David M, Shehatou, George S G, Giblett, Susan, Pullar, Christine E, Trezise, Derek J, Pritchard, Catrin A, Challiss, R A John, Mitcheson, John S

“…Both human ether-à-go-go-related gene (hERG1) and the closely related human ether-à-go-go (hEAG1) channel are aberrantly expressed in a large proportion of…”
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Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum by Chen, Mao Xiang, Gorman, Shelby A, Benson, Bill, Singh, Kuljit, Hieble, J Paul, Michel, Martin C, Tate, Simon N, Trezise, Derek J

“…The SK/IK family of small and intermediate conductance calcium-activated potassium channels contains four members, SK1, SK2, SK3 and IK1, and is important for…”
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Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons by Lappin, Sarah C., Dale, Tim J., Brown, Jon T., Trezise, Derek J., Davies, Ceri H.

“…The role of calcium-activated potassium channels in the regulation of neuronal hyperexcitability, as in epilepsy, is unclear. To examine this issue, we have…”
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Use of planar array electrophysiology for the development of robust ion channel cell lines by Clare, Jeffrey J, Chen, Mao Xiang, Downie, David L, Trezise, Derek J, Powell, Andrew J

“…The tractability of ion channels as drug targets has been significantly improved by the advent of planar array electrophysiology platforms which have…”
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Abstract 749: Antibody internalization assays for cancer drug discovery by Bevan, Nicola J., Dale, Tim J., Trezise, Derek J.

“…Monoclonal antibodies (mAb) and antibody-drug conjugates (ADCs) are widely used as anti-cancer therapeutics. A key property of these biologics is the extent…”
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Abstract 5030: Development and optimization of Matrigel-based multi-spheroid 3D tumor assays using real-time live-cell analysis by Patel, Kalpana, Oliver, Miniver, Holtz, Nevine, Jackson, Tim, Dana, Nicholas, Lovell, Gillian, Bevan, Nicola J., Dale, Tim J., Trezise, Derek J.

“…The tumor-associated extracellular matrix (ECM) provides critical biochemical micro-environment cues, as well as an essential structural scaffold, for solid…”
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Abstract 2156: Quantifying cell subsets and heterogeneity in living cultures using real time live-cell analysis by Bevan, Nicola, Jackson, Tim, Szybut, Clare, Kelsey, Lauren, Campwala, Hinnah, Dale, Tim, Dana, Nicholas, Holtz, Nevine, Endsley, Eric, Appledorn, Dan, Schramm, Cicely, Skerlos, Laura, Lister, Richard, Trezise, Derek J.

“…Considerable heterogeneity exists in the properties and activity of individual cells, even in the simplest cell system. This arises from fundamental…”
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Abstract 4046: Kinetic quantification of caspase-3/7 mediated apoptosis using live-cell imaging by Appledorn, Daniel M., Nelson, Thomas, Dale, Tim, Alcantara, Susana, Artymovich, Katherine, Endsley, Eric W., Trezise, Derek J., Groppi, Vince E.

“…Apoptosis, the biological process by which cells undergo programmed cell death, is required for normal tissue maintenance and development. However, aberrations…”
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The inwardly rectifying K + channel KIR 7.1 controls uterine excitability throughout pregnancy by McCloskey, Conor, Rada, Cara, Bailey, Elizabeth, McCavera, Samantha, van den Berg, Hugo A, Atia, Jolene, Rand, David A, Shmygol, Anatoly, Chan, Yi‐Wah, Quenby, Siobhan, Brosens, Jan J, Vatish, Manu, Zhang, Jie, Denton, Jerod S, Taggart, Michael J, Kettleborough, Catherine, Tickle, David, Jerman, Jeff, Wright, Paul, Dale, Timothy, Kanumilli, Srinivasan, Trezise, Derek J, Thornton, Steve, Brown, Pamela, Catalano, Roberto, Lin, Nan, England, Sarah K, Blanks, Andrew M

“…Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum…”
Get full text

Improved functional expression of recombinant human ether-a-go-go K.sup.+ .sup.channels by cultivation at reduced temperature by Chen, Mao Xiang, Sandow, Shaun L, Doceul, Virginie, Chen, Yu Hua, Harper, Heather, Hamilton, Bruce, Meadows, Helen J, Trezise, Derek J, Clare, Jeff J

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Improved functional expression of recombinant human ether-a-go-go (hERG) K super(+ )channels by cultivation at reduced temperature by Chen, Mao Xiang, Sandow, Shaun L, Doceul, Virginie, Chen, Yu Hua, Harper, Heather, Hamilton, Bruce, Meadows, Helen J, Trezise, Derek J, Clare, Jeff J

“…Background HERG potassium channel blockade is the major cause for drug-induced long QT syndrome, which sometimes cause cardiac disrhythmias and sudden death…”
Get full text

Heterologous expression and functional analysis of rat Na V1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7–23 by John, Victoria H., Main, Martin J., Powell, Andrew J., Gladwell, Zoe M., Hick, Caroline, Sidhu, Harjeet S., Clare, Jeff J., Tate, Simon, Trezise, Derek J.

“…The voltage-gated sodium channel Na V1.8 (SNS, PN3) is thought to be a molecular correlate of the dorsal root ganglion (DRG) tetrodotoxin resistant (TTX-R) Na…”
Get full text