Search Results - "Trevino, Jose G"

The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy by Principe, Daniel R, Underwood, Patrick W, Korc, Murray, Trevino, Jose G, Munshi, Hidayatullah G, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival time of 10-12 months. Clinically, these poor outcomes are attributed to…”
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The Microbiota and Cancer Cachexia by Herremans, Kelly M, Riner, Andrea N, Cameron, Miles E, Trevino, Jose G

“…Cancer cachexia is a multifactorial syndrome defined by weight loss, muscle wasting, and systemic inflammation. It affects the majority of patients with…”
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Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy by Principe, Daniel R, Narbutis, Matthew, Kumar, Sandeep, Park, Alex, Viswakarma, Navin, Dorman, Matthew J, Kamath, Suneel D, Grippo, Paul J, Fishel, Melissa L, Hwang, Rosa F, Thummuri, Dinesh, Underwood, Patrick W, Munshi, Hidayatullah G, Trevino, Jose G, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death with a median survival time of 6-12 months. Most patients present with…”
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A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR by Han, Song, Tushoski-Alemán, Gerik W., Zhang, Peiyi, Zheng, Guangrong, Zhou, Daohong, Huo, Zhiguang, Licht, Jonathan, George, Thomas J., Allegra, Carmen, Trevino, Jose G., Hughes, Steven J.

“…•Oncogenic KRAS, the key driver for PDAC, currently lacks effective targeting therapy.•Triple inhibition of MEK, BCL-xL and EGFR showed enhanced tumor…”
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Patient-Derived Xenograft Models for Pancreatic Adenocarcinoma Demonstrate Retention of Tumor Morphology through Incorporation of Murine Stromal Elements by Delitto, Daniel, Pham, Kien, Vlada, Adrian C, Sarosi, George A, Thomas, Ryan M, Behrns, Kevin E, Liu, Chen, Hughes, Steven J, Wallet, Shannon M, Trevino, Jose G

“…Direct implantation of viable surgical specimens provides a representative preclinical platform in pancreatic adenocarcinoma. Patient-derived xenografts…”
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Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients by Biel, Thomas G, Petrovskaya, Svetlana, Mascia, Francesca, Ju, Tongzhong, Fashoyin-Aje, Lola, Herremans, Kelly M, Riner, Andrea N, Underwood, Patrick W, Gerber, Michael H, Donoghue, Martha, Trevino, Jose G, Rao, V Ashutosh

“…In pancreatic cancer clinical trials, Black patients are under-represented while having higher morbidity and mortality rates as compared to other racial…”
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Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer by Tushoski-Alemán, Gerik W, Herremans, Kelly M, Underwood, Patrick W, Akki, Ashwin, Riner, Andrea N, Trevino, Jose G, Han, Song, Hughes, Steven J

“…Pancreatic ductal adenocarcinomas (PDAC) have heterogeneous tumor microenvironments relatively devoid of infiltrating immune cells. We aimed to quantitatively…”
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Nicotine Induces Inhibitor of Differentiation-1 in a Src-dependent Pathway Promoting Metastasis and Chemoresistance in Pancreatic Adenocarcinoma by Trevino, Jose G, Pillai, Smitha, Kunigal, Sateesh, Singh, Sandeep, Fulp, William J, Centeno, Barbara A, Chellappan, Srikumar P

“…Smoking is a significant risk factor for pancreatic cancer, but the molecular mechanisms by which tobacco smoke components promote the growth and progression…”
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c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer by Delitto, Daniel, Vertes-George, Eva, Hughes, Steven J, Behrns, Kevin E, Trevino, Jose G

“…Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States.The majority of patients are candidates only for palliative…”
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Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer by Murphy, Kate T, Hossain, Mohammed I, Swiderski, Kristy, Chee, Annabel, Naim, Timur, Trieu, Jennifer, Haynes, Vanessa, Read, Suzannah J, Stapleton, David I, Judge, Sarah M, Trevino, Jose G, Judge, Andrew R, Lynch, Gordon S

“…Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significant functional impairment…”
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The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine by Herremans, Kelly M, Riner, Andrea N, Cameron, Miles E, McKinley, Kelley L, Triplett, Eric W, Hughes, Steven J, Trevino, Jose G

“…Pancreatic cancer is a deadly disease with limited diagnostic and treatment options. Not all populations are affected equally, as disparities exist in…”
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Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model by Cai, Weijing, Ratnayake, Ranjala, Gerber, Michael H., Chen, Qi-Yin, Yu, Yichao, Derendorf, Hartmut, Trevino, Jose G., Luesch, Hendrik

“…Summary Despite the significant progress in the field of cancer therapeutics, the incidence of pancreatic cancer (PC) has continuously increased. One possible…”
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Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer by Principe, Daniel R, Underwood, Patrick W, Kumar, Sandeep, Timbers, Kaytlin E, Koch, Regina M, Trevino, Jose G, Munshi, Hidayatullah G, Rana, Ajay

“…Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in…”
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Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies by Delitto, Daniel, Luckhurst, Casey M., Black, Brian S., Beck, John L., George, Thomas J., Sarosi, George A., Thomas, Ryan M., Trevino, Jose G., Behrns, Kevin E., Hughes, Steven J.

“…Background Data are sparse regarding patient selection criteria or evaluating oncologic outcomes following laparoscopic pancreaticoduodenectomy (LPD). Having…”
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Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas by Permuth, Jennifer B., Chen, Dung-Tsa, Yoder, Sean J., Li, Jiannong, Smith, Andrew T., Choi, Jung W., Kim, Jongphil, Balagurunathan, Yoganand, Jiang, Kun, Coppola, Domenico, Centeno, Barbara A., Klapman, Jason, Hodul, Pam, Karreth, Florian A., Trevino, Jose G., Merchant, Nipun, Magliocco, Anthony, Malafa, Mokenge P., Gillies, Robert

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long…”
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Disconnected Pancreatic Duct Syndrome: Disease Classification and Management Strategies by Fischer, Trevan D., MD, Gutman, Daniel S., BS, Hughes, Steven J., MD, FACS, Trevino, Jose G., MD, FACS, Behrns, Kevin E., MD, FACS

“…Background Disconnected pancreatic duct syndrome (DPDS) typically complicates acute necrotizing pancreatitis (ANP) and presents as a pseudocyst months after…”
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FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness by Neyroud, Daria, Nosacka, Rachel L., Callaway, Chandler S., Trevino, Jose G., Hu, Hui, Judge, Sarah M., Judge, Andrew R.

“…Background Skeletal muscle wasting is a devastating consequence of cancer that affects up to 80% of cancer patients and associates with reduced survival…”
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A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer by Delitto, Daniel, MD, PhD, Judge, Sarah M., PhD, George, Thomas J., MD, Sarosi, George A., MD, Thomas, Ryan M., MD, Behrns, Kevin E., MD, Hughes, Steven J., MD, Judge, Andrew R., PhD, Trevino, Jose G., MD

“…Background The relationship between myopenia, nutritional status, and long-term oncologic outcomes remains poorly characterized in patients with clinically…”
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Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle by Nosacka, Rachel L., Delitto, Andrea E., Delitto, Dan, Patel, Rohan, Judge, Sarah M., Trevino, Jose G., Judge, Andrew R.

“…Background Cancer cachexia is a life‐threatening metabolic syndrome that causes significant loss of skeletal muscle mass and significantly increases mortality…”
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Human Norovirus Triggers Primary B Cell Immune Activation In Vitro by Mirabelli, Carmen, Jones, Melissa K, Young, Vivienne L, Kolawole, Abimbola O, Owusu, Irene, Shan, Mengrou, Abuaita, Basel, Turula, Holly, Trevino, Jose G, Grigorova, Irina, Lundy, Steven K, Lyssiotis, Costas A, Ward, Vernon K, Karst, Stephanie M, Wobus, Christiane E

“…Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The…”
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