Search Results - "Trevaks, Ruth"
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Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
Published in The New England journal of medicine (18-10-2018)“…In older persons without known cardiovascular disease, the use of low-dose aspirin resulted in a significantly higher risk of major hemorrhage and did not…”
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Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
Published in The New England journal of medicine (18-10-2018)“…After a median follow-up of 4.7 years, there were 1.6 more deaths per 1000 person-years among healthy older adults who were randomly assigned to receive…”
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Effect of Aspirin on Disability-free Survival in the Healthy Elderly
Published in The New England journal of medicine (18-10-2018)“…In a trial comparing 100 mg of aspirin with placebo in nearly 20,000 community-dwelling persons 70 years of age or older in Australia and the United States,…”
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Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-11-2017)“…There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a…”
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Normative performance of older individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) according to ethno-racial group, gender, age and education level
Published in Clinical neuropsychologist (09-07-2021)“…The Hopkins Verbal Learning Test-Revised (HVLT-R) provides a measure of verbal learning and memory. The aim of this study was to provide normative performance…”
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Obstructive sleep apnea and cerebral small vessel disease in community-based older people: an aspirin in reducing events in the elderly imaging substudy
Published in Sleep (New York, N.Y.) (05-10-2024)“…Abstract Study Objectives Obstructive sleep apnea (OSA) may increase the risk of dementia. A potential pathway for this risk is through cerebral small vessel…”
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Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study
Published in Medical journal of Australia (01-03-2019)“…Objective To assess the factors that contributed to the successful completion of recruitment for the largest clinical trial ever conducted in Australia, the…”
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Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-11-2021)“…Abstract Background Cerebrovascular events, dementia, and cancer can contribute to physical disability with activities of daily living (ADL). It is unclear…”
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The association between sex hormones and the change in brain‐predicted age difference in older women
Published in Clinical endocrinology (Oxford) (01-05-2023)“…Objective The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating…”
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Sleep‐disordered breathing was associated with lower health‐related quality of life and cognitive function in a cross‐sectional study of older adults
Published in Respirology (Carlton, Vic.) (01-09-2022)“…Background and objective The clinical significance of sleep‐disordered breathing (SDB) in older age is uncertain. This study determined the prevalence and…”
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Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function
Published in Frontiers in aging neuroscience (04-01-2023)“…Neuroimaging-based 'brain age' can identify individuals with 'advanced' or 'resilient' brain aging. Brain-predicted age difference (brain-PAD) is predictive of…”
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Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level
Published in Clinical neuropsychologist (19-05-2019)“…Objective: To present normative performance data on the Modified Mini-Mental State (3MS) examination for healthy community-dwelling older individuals according…”
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Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos
Published in JAD reports (04-08-2020)“…Background: Processing speed, which can be assessed using the Symbol Digit Modalities Test (SDMT), is central to many brain functions. Processing speed…”
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ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly
Published in International journal of stroke (01-01-2017)“…Rationale Cerebral microbleeds seen on brain magnetic resonance imaging are markers of small vessel disease, linked to cognitive dysfunction and increased…”
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Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study
Published in American journal of hypertension (01-04-2020)“…Abstract BACKGROUND Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in…”
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Baseline characteristics and age-related macular degeneration in participants of the “ASPirin in Reducing Events in the Elderly” (ASPREE)-AMD trial
Published in Contemporary clinical trials communications (01-12-2020)“…To describe the baseline participant characteristics in the ASPREE-AMD study, investigating the effect of aspirin on AMD incidence and progression. Australian…”
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Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals
Published in JAD reports (01-01-2022)“…Background: There is considerable variability in the rate at which we age biologically, and the brain is particularly susceptible to the effects of aging…”
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Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline
Published in Neurology (21-07-2020)“…OBJECTIVETo determine the effect of low-dose aspirin vs placebo on incident all-cause dementia, incident Alzheimer disease (AD), mild cognitive impairment…”
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Brain-predicted age difference is associated with cognitive processing in later-life
Published in Neurobiology of aging (01-01-2022)“…•Brain age was measured in 531 older community-dwelling individuals (aged ≥70 years).•Brain-predicted age difference (Brain-PAD) was defined as the difference…”
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